HeLa cells 50 years on: the good, the bad and the ugly (original) (raw)

• Lewis, W. H. Malignant cells. The Harvey Lectures 31, 214–234 (1936).
  Google Scholar
• Harrison, R. G. Observations on the living developing nerve fiber. Proc. Soc. Exp. Biol. Med. 4, 140–143 (1907).
  Article Google Scholar
• Carrel, A. On the permanent life of tissues outside the organism. J. Exp. Med. 15, 516–528 (1912).
  Article CAS Google Scholar
• Burrows, M. T. The cultivation of tissues of the chick embryo outside the body. J. Am. Med. Assoc. 55, 2057–2058 (1910).
  Article Google Scholar
• Earle, W. R. et al. Production of malignancy in vitro. IV. The mouse fibroblast cultures and changes seen in living cells. J. Natl Cancer Inst. 4, 165–212 (1943).
  CAS Google Scholar
• Gey, G. O., Coffman, W. D. & Kubicek, M. T. Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. Cancer Res. 12, 264–265 (1952).
  Google Scholar
• Gold, M. A Conspiracy of Cells. One Woman's Immortal Legacy and the Scandal it Caused (State Univ. New York Press, New York, 1986).
  Google Scholar
• Jones, H. W., McKusick, V. A., Harper, P. S. & Wuu K. D. The HeLa cell and a reappraisal of its origin. Obstet. Gynecol. 38, 945–949 (1971).
  PubMed Google Scholar
• Masters, J. R. W. & Palsson, B. Ø. (eds) Human Cell Culture Vol. 1–3 (Kluwer Academic, Dordrecht, 1999).
  Book Google Scholar
• Masters, J. R. W. Human cancer cell lines: fact and fantasy. Nature Rev. Mol. Cell Biol. 1, 233–236 (2000).
  Article CAS Google Scholar
• Wistuba, I. I. et al. Comparison of features of human breast cancer cell lines and their corresponding tumours. Clin. Cancer Res. 4, 2931–2938 (1998).
  CAS PubMed Google Scholar
• Sanford, K. K. & Evans, V. J. A quest for the mechanism of 'spontaneous' malignant transformation in culture with associated advances in culture technology. J. Natl Cancer Inst. 68, 895–913 (1982).
  CAS PubMed Google Scholar
• UKCCCR guidelines for the use of cancer cell lines in cancer research. Br. J. Cancer 82, 1495–1509 (2000).
• Macville, M. et al. Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping. Cancer Res. 59, 141–150 (1999).
  CAS PubMed Google Scholar
• Scherer, W. F., Syverton, J. T. & Gey, G. O. Studies on the propagation in vitro of poliomyelitis viruses. J. Exp. Med. 97, 695–709 (1953).
  Article CAS Google Scholar
• Brown, R. W. & Henderson, J. H. M. The mass production and distribution of HeLa cells at Tuskegee Institute, 1953–55. J. Hist. Med. Allied Sci. 38, 415–431 (1983).
  Article CAS Google Scholar
• Arlett, C. F. The use of dubious cell lines in research: is trust enough? Lancet Oncol. 2, 467 (2001).
  Article CAS Google Scholar
• Rothfels, K. H., Axelrad, A. A., Siminovitch, L., McCulloch, E. A. & Parker, R. C. in Proc. 3rd Canadian Cancer Research Conference 1958 (ed. Begg, R. W.) 189–214 (Academic, New York, 1958).
  Google Scholar
• Gartler, S. M. Genetic markers as tracers in cell culture. Natl Cancer Inst. Monogr. 26, 167–195 (1967).
  CAS PubMed Google Scholar
• Gartler, S. M. Apparent HeLa cell contamination of human heteroploid cell lines. Nature 217, 750–751 (1968).
  Article CAS Google Scholar
• Nelson-Rees, W. A., Flandermeyer, R. R. & Hawthorne, P. K. Banded marker chromosomes as indicators of intraspecies cellular contamination. Science 184, 1093 (1974).
  Article CAS Google Scholar
• Nelson-Rees, W. A. & Flandermeyer, R. R. HeLa cultures defined. Science 191, 96–98 (1976).
  Article CAS Google Scholar
• Nelson-Rees, W. A., Daniels, D. W. & Flandermeyer, R. R. Cross-contamination of cells in culture. Science 212, 446–452 (1981).
  Article CAS Google Scholar
• Nelson-Rees, W. A. Responsibility for truth in research. Phil. Trans. R. Soc. Lond. B356, 849–851 (2001).
  Article Google Scholar
• Editorial. Responsibility for trust in research. Nature 289, 211–212 (1981).
• Markovic, O. & Markovic, N. Cell cross-contamination in cell cultures: the silent and neglected danger. In Vitro Cell Dev. Biol. 34, 1–8 (1998).
  Article CAS Google Scholar
• MacLeod, R. A. F. et al. Widespread intraspecies cross-contamination of human tumour cell lines. Int. J. Cancer 83, 555–563 (1999).
  Article CAS Google Scholar
• Dirks, W. G., MacLeod, R. A. & Drexler, H. G. ECV304 (endothelial) is really T24 (bladder carcinoma): cell line cross-contamination at source. In Vitro Cell Dev. Biol. 35, 558–559 (1999).
  Article CAS Google Scholar
• Drexler, H. G., Uphoff, C. C., Dirks, W. G. & MacLeod, R. A. F. Mix–ups and mycoplasma: the enemies within. Leukemia Res. (in the press).
• Drexler, H. G., MacLeod, R. A. F. & Dirks, W. G. Cross-contamination: HS-Sultan is not a myeloma but a Burkitt lymphoma cell line. Blood 98, 3495–3496 (2001).
  Article CAS Google Scholar
• Masters, J. R. W. et al. STR profiling provides an international reference standard for human cell lines. Proc. Natl Acad. Sci. USA 98, 8012–8017 (2001).
  Article CAS Google Scholar
• Stacey, G. N. et al. Cell contamination leads to inaccurate data: we must take action now. Nature 403, 356 (2000).
  Article CAS Google Scholar
• Eagle, H. Propagation in a fluid medium of a human epidermoid carcinoma, strain KB. Proc. Soc. Exp. Biol. Med. 89, 362–364 (1955).
  Article CAS Google Scholar
• Kothny-Wilkes, G. et al. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand. J. Biol. Chem. 273, 29247–29253 (1998).
  Article CAS Google Scholar
• Goan, Y. G., Zhou, B., Hu, E., Mi, S. & Yen, Y. Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line. Cancer Res. 59, 4204–4207 (1999).
  CAS PubMed Google Scholar
• Fjelde, A. Human tumor cells in tissue culture. Cancer 8, 845–851 (1955).
  Article CAS Google Scholar
• Galmiche, A. et al. The N-terminal 34kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J. 19, 6361 (2000).
  Article CAS Google Scholar
• Munger, J., Chee, A. V. & Roizman, B. The U(S)3 protein kinase blocks apoptosis induced by the d120 mutant of herpes simplex virus 1 at a premitochondria stage. J. Virol. 75, 5491–5497 (2001).
  Article CAS Google Scholar
• Hayflick, L. The establishment of a line (WISH) of human amnion cells in continuous cultivation. Exp. Cell Res. 23, 14–20 (1961).
  Article CAS Google Scholar
• Pavan, B., Biondi, C., Ferretti, M. E., Lunghi, L. & Paganetto, G. 17β-estadiol modulates prostaglandin E2 release from human amnion-derived wish cells. Biol. Reprod. 64, 1677–1681 (2001).
  Article CAS Google Scholar
• Gayraud, B., Keene, D. R., Sakai, L. Y. & Ramirez, F. New insights into the assembly of extracellular microfobrils from the analysis of the fibrillin 1 mutation in the tight skin mouse. J. Cell Biol. 150, 667–680 (2000).
  Article CAS Google Scholar
• Davis, E. V. & Bolin, V. S. Continuous cultivation of isogenous cell lines from the human embryo. Fed. Proc. 19, 386 (1960).
  Google Scholar
• Kasper, M. et al. Induction of apoptosis by glyoxal in human embryonic lung epithelial cell line L132. Am. J. Respir. Cell Mol. Biol. 23, 485–491 (2000).
  Article CAS Google Scholar
• Roos, W. P., Binder, A. & Bohm, L. Determination of the initial DNA damage and residual DNA damage remaining after 12 hours of repair in eleven cell lines at low doses of irradiation. Int. J. Radiat. Biol. 76, 1493–1500 (2000).
  Article CAS Google Scholar
• Henle, G. & Deinhardt, F. J. The establishment of strains of human cells in tissue culture. J. Immunol. 79, 54–59 (1957).
  CAS PubMed Google Scholar
• Takaishi, S. et al. Identification of a novel altrenative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells. Biochem. Biophys. Res. Commun. 267, 658–662 (2000).
  Article CAS Google Scholar
• Tsumura, T., Oiki, S., Ueda, S., Okuma, M. & Okada, Y. Sensitivity of volume-sensitive Cl− conductance in human epithelial cells to extracellular nucleotides. Am. J. Physiol. 271, C1872–C1878 (1996).
  Article CAS Google Scholar
• Chang, R. S. Continuous subcultivation of epithelial-like cells from normal human tissues. Proc. Soc. Exp. Biol. Med. 87, 440–443 (1954).
  Article CAS Google Scholar
• Li, Y. et al. A hepatocellular carcinoma-specific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicin. Cancer Res. 61, 6428–6436 (2001).
  CAS PubMed Google Scholar
• Lee, Y. I., Kang-Park, S., Do, S. I. & Lee, Y. I. The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 276, 16969–16977 (2001).
  Article CAS Google Scholar