New leptin sensitizer identified (original) (raw)

• Research Highlight
• Published: 12 August 2016

Obesity

Nature Reviews Endocrinology volume 12, page 558 (2016)Cite this article

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In previous work, some of the authors of this paper identified celastrol as a leptin sensitizer that could induce weight loss in DIO mice, leading them to hypothesize that molecules with a similar gene expression signature to celastrol would also affect leptin sensitization.

The researchers first established the gene expression signature of celastrol, and then searched the Broad Institute Connectivity Map database for molecules with a similar gene expression signature. Withaferin A was identified as the molecule with a gene expression signature most similar to that of celastrol.

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Greenhill, C. New leptin sensitizer identified.Nat Rev Endocrinol 12, 558 (2016). https://doi.org/10.1038/nrendo.2016.133

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• Published: 12 August 2016
• Issue date: October 2016
• DOI: https://doi.org/10.1038/nrendo.2016.133

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