Interleukin-1 and neuronal injury (original) (raw)
Huising, M. O., Stet, R. J., Savelkoul, H. F. & Verburg-van Kemenade, B. M. The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish. Dev. Comp. Immunol.28, 395–413 (2004). ArticleCASPubMed Google Scholar
March, C. J. et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature315, 641–647 (1985). ArticleCASPubMed Google Scholar
Thornberry, N. A. et al. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature356, 768–774 (1992). A key paper that identified the enzyme that is responsible for cleavage of inactive pro-IL-1β to the mature biologically active protein. ArticleCASPubMed Google Scholar
Sims, J. E. et al. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science241, 585–589 (1988). ArticleCASPubMed Google Scholar
Korherr, C., Hofmeister, R., Wesche, H. & Falk, W. A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling. Eur. J. Immunol.27, 262–267 (1997). An important paper that shows that recruitment of an accessory protein to the IL-1–IL-1R1 complex is essential for signal transduction to take place. ArticleCASPubMed Google Scholar
Subramaniam, S., Stansberg, C. & Cunningham, C. The interleukin 1 receptor family. Dev. Comp. Immunol.28, 415–428 (2004). ArticleCASPubMed Google Scholar
Hannum, C. H. et al. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature343, 336–340 (1990). ArticleCASPubMed Google Scholar
Malyak, M., Smith, M. F. Jr, Abel, A. A., Hance, K. R. & Arend, W. P. The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes. J. Immunol.161, 2004–2010 (1998). CASPubMed Google Scholar
Dinarello, C. A. et al. Overview of interleukin-18: more than an interferon-γ inducing factor. J. Leukoc. Biol.63, 658–664 (1998). ArticleCASPubMed Google Scholar
Dunne, A. & O'Neill, L. A. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci. STKE [online] 2003, RE3 (2003). A valuable updated review of the receptors of the IL-1-receptor and TLR family, and their signalling pathways. PubMed Google Scholar
Sims, J. E. et al. A new nomenclature for IL-1-family genes. Trends Immunol.22, 536–537 (2001). ArticleCASPubMed Google Scholar
Sims, J. E. IL-1 and IL-18 receptors, and their extended family. Curr. Opin. Immunol.14, 117–122 (2002). ArticleCASPubMed Google Scholar
Vitkovic, L., Bockaert, J. & Jacque, C. 'Inflammatory' cytokines: neuromodulators in normal brain? J. Neurochem.74, 457–471 (2000). ArticleCASPubMed Google Scholar
Watkins, L. R., Hansen, M. K., Nguyen, K. T., Lee, J. E. & Maier, S. F. Dynamic regulation of the proinflammatory cytokine, interleukin-1β: molecular biology for non-molecular biologists. Life Sci.65, 449–481 (1999). ArticleCASPubMed Google Scholar
Hsu, H. Y. & Wen, M. H. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J. Biol. Chem.277, 22131–22139 (2002). ArticleCASPubMed Google Scholar
Perregaux, D. G., Bhavsar, K., Contillo, L., Shi, J. & Gabel, C. A. Antimicrobial peptides initiate IL-1β posttranslational processing: a novel role beyond innate immunity. J. Immunol.168, 3024–3032 (2002). ArticleCASPubMed Google Scholar
Eriksson, C., Tehranian, R., Iverfeldt, K., Winblad, B. & Schultzberg, M. Increased expression of mRNA encoding interleukin-1β and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration. J. Neurosci. Res.60, 266–279 (2000). ArticleCASPubMed Google Scholar
Liu, L., Li, Y., Van Eldik, L. J., Griffin, W. S. & Barger, S. W. S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. J. Neurochem.92, 546–553 (2005). ArticleCASPubMed Google Scholar
Relton, J. K. et al. Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain. J. Exp. Med.174, 305–310 (1991). ArticleCASPubMed Google Scholar
Kern, J. A., Warnock, L. J. & McCafferty, J. D. The 3′ untranslated region of IL-1β regulates protein production. J. Immunol.158, 1187–1193 (1997). CASPubMed Google Scholar
Hazuda, D. J., Strickler, J., Kueppers, F., Simon, P. L. & Young, P. R. Processing of precursor interleukin 1β and inflammatory disease. J. Biol. Chem.265, 6318–6322 (1990). CASPubMed Google Scholar
Perregaux, D. & Gabel, C. A. Interleukin-1β maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J. Biol. Chem.269, 15195–15203 (1994). CASPubMed Google Scholar
Le Feuvre, R. A., Brough, D., Iwakura, Y., Takeda, K. & Rothwell, N. J. Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J. Biol. Chem.277, 3210–3218 (2002). ArticleCASPubMed Google Scholar
Brough, D. et al. Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages. J. Immunol.170, 3029–3036 (2003). ArticleCASPubMed Google Scholar
Andrei, C. et al. Phospholipases C and A2 control lysosome-mediated IL-1β secretion: implications for inflammatory processes. Proc. Natl Acad. Sci. USA101, 9745–9750 (2004). ArticleCASPubMed Google Scholar
Walev, I., Reske, K., Palmer, M., Valeva, A. & Bhakdi, S. Potassium-inhibited processing of IL-1β in human monocytes. EMBO J.14, 1607–1614 (1995). ArticleCASPubMedPubMed Central Google Scholar
Ferrari, D. et al. P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death. FEBS Lett.447, 71–75 (1999). ArticleCASPubMed Google Scholar
Elssner, A., Duncan, M., Gavrilin, M. & Wewers, M. D. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1β processing and release. J. Immunol.172, 4987–4994 (2004). ArticleCASPubMed Google Scholar
Perregaux, D. G. et al. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J. Pharmacol. Exp. Ther.299, 187–197 (2001). CASPubMed Google Scholar
Laliberte, R. E. et al. Glutathione _S_-transferase ω 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing. J. Biol. Chem.278, 16567–16578 (2003). ArticleCASPubMed Google Scholar
Li, Y. J. et al. Glutathione _S_-transferase ω-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Hum. Mol. Genet.12, 3259–3267 (2003). ArticleCASPubMed Google Scholar
Schneider, H. et al. A neuromodulatory role of interleukin-1β in the hippocampus. Proc. Natl Acad. Sci. USA95, 7778–7783 (1998). ArticleCASPubMed Google Scholar
Kelley, K. W. et al. Cytokine-induced sickness behavior. Brain Behav. Immun.17, S112–S118 (2003). ArticleCASPubMed Google Scholar
Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F. & Besedovsky, H. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science238, 524–526 (1987). ArticleCASPubMed Google Scholar
Boutin, H., Kimber, I., Rothwell, N. J. & Pinteaux, E. The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain? Mol. Neurobiol.27, 239–248 (2003). ArticleCASPubMed Google Scholar
Debets, R. et al. Two novel IL-1 family members, IL-1δ and IL-1ε, function as an antagonist and agonist of NF-κB activation through the orphan IL- 1 receptor-related protein 2. J. Immunol.167, 1440–1446 (2001). ArticleCASPubMed Google Scholar
Lovenberg, T. W. et al. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2). J. Neuroimmunol.70, 113–122 (1996). ArticleCASPubMed Google Scholar
Berglof, E. et al. IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells. J. Neuroimmunol.139, 36–43 (2003). ArticleCASPubMed Google Scholar
Wang, P. et al. The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1β signalling responses. Cytokine29, 245–250 (2005). PubMed Google Scholar
Ching, S., He, L., Lai, W. & Quan, N. IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav. Immun.19, 127–137 (2005). ArticleCASPubMed Google Scholar
Loddick, S. A. et al. Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochem. Biophys. Res. Commun.234, 211–215 (1997). ArticleCASPubMed Google Scholar
Carvey, P. M. et al. Intra-parenchymal injection of tumor necrosis factor-α and interleukin 1-β produces dopamine neuron loss in the rat. J. Neural Transm.112, 601–612 (2005). One of the few papers to show direct neurotoxic effects of IL-1. ArticleCASPubMed Google Scholar
Lawrence, C. B., Allan, S. M. & Rothwell, N. J. Interleukin-1β and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat. Eur. J. Neurosci.10, 1188–1195 (1998). ArticleCASPubMed Google Scholar
Chao, C. C., Hu, S., Ehrlich, L. & Peterson, P. K. Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: involvement of nitric oxide and of _N_-methyl-D-aspartate receptors. Brain. Behav. Immun.9, 355–365 (1995). ArticleCASPubMed Google Scholar
Hu, S., Peterson, P. K. & Chao, C. C. Cytokine-mediated neuronal apoptosis. Neurochem. Int.30, 427–431 (1997). ArticleCASPubMed Google Scholar
Downen, M., Amaral, T. D., Hua, L. L., Zhao, M. L. & Lee, S. C. Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-α. Glia28, 114–127 (1999). ArticleCASPubMed Google Scholar
Yamasaki, Y. et al. Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke26, 676–681 (1995). The first study to show that administration of exogenous IL-1 can exacerbate experimental neuronal injury. ArticleCASPubMed Google Scholar
Relton, J. K. & Rothwell, N. J. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res. Bull.29, 243–246 (1992). The first paper to report the neuroprotective effects of IL-1RA in neuronal injury. ArticleCASPubMed Google Scholar
Rothwell, N. Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behav. Immun.17, 152–157 (2003). ArticlePubMed Google Scholar
Vezzani, A. et al. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc. Natl Acad. Sci. USA97, 11534–11539 (2000). ArticleCASPubMed Google Scholar
Lin, M. T., Kao, T. Y., Jin, Y. T. & Chen, C. F. Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats. Brain Res. Bull.37, 595–598 (1995). ArticleCASPubMed Google Scholar
Loscher, C. E., Mills, K. H. & Lynch, M. A. Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor. J. Neuroimmunol.137, 117–124 (2003). ArticleCASPubMed Google Scholar
Hara, H. et al. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl Acad. Sci. USA94, 2007–2012 (1997). The first paper to show that inhibition of the enzyme responsible for production of the mature, active IL-1β protein provides neuroprotection. ArticleCASPubMed Google Scholar
Boutin, H. et al. Role of IL-1α and IL-1β in ischemic brain damage. J. Neurosci.21, 5528–5534 (2001). ArticleCASPubMed Google Scholar
Boutin, H. & Rothwell, N. J. in Pharmacology of Cerebral Ischaemia (eds Krieglstein, J. & Klumpp, S.) 183–190 (Medpharm, Stuttgart, 2002). Google Scholar
Strijbos, P. J. & Rothwell, N. J. Interleukin-1β attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. J. Neurosci.15, 3468–3474 (1995). ArticleCASPubMed Google Scholar
Carlson, N. G. et al. Inflammatory cytokines IL-1α, IL-1β, IL-6, and TNF-α impart neuroprotection to an excitotoxin through distinct pathways. J. Immunol.163, 3963–3968 (1999). CASPubMed Google Scholar
Viviani, B. et al. Interleukin-1β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J. Neurosci.23, 8692–8700 (2003). ArticleCASPubMed Google Scholar
Pringle, A. K., Niyadurupola, N., Johns, P., Anthony, D. C. & Iannotti, F. Interleukin-1β exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures. Neurosci. Lett.305, 29–32 (2001). ArticleCASPubMed Google Scholar
Busto, R. et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J. Cereb. Blood Flow Metab.7, 729–738 (1987). ArticleCASPubMed Google Scholar
Azzimondi, G. et al. Fever in acute stroke worsens prognosis. A prospective study. Stroke26, 2040–2043 (1995). ArticleCASPubMed Google Scholar
Monroy, M., Kuluz, J. W., He, D., Dietrich, W. D. & Schleien, C. L. Role of nitric oxide in the cerebrovascular and thermoregulatory response to interleukin-1β. Am. J. Physiol. Heart Circ. Physiol.280, H1448–H1453 (2001). ArticleCASPubMed Google Scholar
Maher, C. O., Anderson, R. E., Martin, H. S., McClelland, R. L. & Meyer, F. B. Interleukin-1β and adverse effects on cerebral blood flow during long-term global hypoperfusion. J. Neurosurg.99, 907–912 (2003). ArticleCASPubMed Google Scholar
Fassbender, K., Schmidt, R., Mossner, R., Daffertshofer, M. & Hennerici, M. Pattern of activation of the hypothalamic–pituitary–adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome. Stroke25, 1105–1108 (1994). ArticleCASPubMed Google Scholar
Srinivasan, D., Yen, J. H., Joseph, D. J. & Friedman, W. Cell type-specific interleukin-1β signaling in the CNS. J. Neurosci.24, 6482–6488 (2004). ArticleCASPubMed Google Scholar
Touzani, O. et al. Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor. J. Neurosci.22, 38–43 (2002). The first report that IL-1β has effects in the CNS that are not mediated through binding IL-1R1, the classical IL-1 signalling receptor. ArticleCASPubMed Google Scholar
Basu, A. et al. Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J. Cereb. Blood Flow Metab.25, 17–29 (2005). ArticleCASPubMed Google Scholar
Parker, L. C., Luheshi, G. N., Rothwell, N. J. & Pinteaux, E. IL-1β signalling in glial cells in wildtype and IL-1RI deficient mice. Br. J. Pharmacol.136, 312–320 (2002). ArticleCASPubMedPubMed Central Google Scholar
Allan, S. M. & Rothwell, N. J. Cytokines and acute neurodegeneration. Nature Rev. Neurosci.2, 734–744 (2001). ArticleCAS Google Scholar
Vezzani, A. et al. Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J. Neurosci.19, 5054–5065 (1999). ArticleCASPubMed Google Scholar
Chen, Y. & Swanson, R. A. Astrocytes and brain injury. J. Cereb. Blood Flow Metab.23, 137–149 (2003). ArticlePubMed Google Scholar
John, G. R., Lee, S. C., Song, X., Rivieccio, M. & Brosnan, C. F. IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia49, 161–176 (2005). ArticlePubMed Google Scholar
Basu, A., Krady, J. K. & Levison, S. W. Interleukin-1: a master regulator of neuroinflammation. J. Neurosci. Res.78, 151–156 (2004). ArticleCASPubMed Google Scholar
Pinteaux, E., Parker, L. C., Rothwell, N. J. & Luheshi, G. N. Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J. Neurochem.83, 754–763 (2002). ArticleCASPubMed Google Scholar
Vela, J. M., Molina-Holgado, E., Arevalo-Martin, A., Almazan, G. & Guaza, C. Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol. Cell. Neurosci.20, 489–502 (2002). ArticleCASPubMed Google Scholar
Mason, J. L., Suzuki, K., Chaplin, D. D. & Matsushima, G. K. Interleukin-1β promotes repair of the CNS. J. Neurosci.21, 7046–7052 (2001). ArticleCASPubMed Google Scholar
Konsman, J. P., Vigues, S., Mackerlova, L., Bristow, A. & Blomqvist, A. Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. J. Comp. Neurol.472, 113–129 (2004). ArticlePubMed Google Scholar
Proescholdt, M. G. et al. Intracerebroventricular but not intravenous interleukin-1β induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation. Neuroscience112, 731–749 (2002). ArticleCASPubMed Google Scholar
Bernardes-Silva, M., Anthony, D. C., Issekutz, A. C. & Perry, V. H. Recruitment of neutrophils across the blood–brain barrier: the role of E- and P-selectins. J. Cereb. Blood Flow Metab.21, 1115–1124 (2001). ArticleCASPubMed Google Scholar
Anthony, D. et al. CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood–brain barrier breakdown. Curr. Biol.8, 923–926 (1998). ArticleCASPubMed Google Scholar
Mazzotta, G. et al. Different cytokine levels in thrombolysis patients as predictors for clinical outcome. Eur. J. Neurol.11, 377–381 (2004). ArticleCASPubMed Google Scholar
Fassbender, K. et al. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. J. Neurol. Sci.122, 135–139 (1994). ArticleCASPubMed Google Scholar
Tarkowski, E. et al. Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke26, 1393–1398 (1995). One of the earliest studies to show that concentrations of IL-1β are increased in patients who have suffered a clinical stroke. ArticleCASPubMed Google Scholar
Kostulas, N., Pelidou, S. H., Kivisakk, P., Kostulas, V. & Link, H. Increased IL-1β, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study. Stroke30, 2174–2179 (1999). ArticleCASPubMed Google Scholar
Beamer, N. B., Coull, B. M., Clark, W. M., Hazel, J. S. & Silberger, J. R. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann. Neurol.37, 800–805 (1995). ArticleCASPubMed Google Scholar
Fassbender, K. et al. Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries. J. Neurol. Neurosurg. Psychiatry70, 534–537 (2001). ArticleCASPubMedPubMed Central Google Scholar
Mathiesen, T., Edner, G., Ulfarsson, E. & Andersson, B. Cerebrospinal fluid interleukin-1 receptor antagonist and tumor necrosis factor-α following subarachnoid hemorrhage. J. Neurosurg.87, 215–220 (1997). ArticleCASPubMed Google Scholar
Gladstone, D. J., Black, S. E. & Hakim, A. M. Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke33, 2123–2136 (2002). ArticlePubMed Google Scholar
Bresnihan, B. The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin. Arthritis Rheum.30, 17–20 (2001). ArticleCASPubMed Google Scholar
Fisher, C. J. Jr. et al. Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial. The IL-1RA Sepsis Syndrome Study Group. Crit. Care Med.22, 12–21 (1994). ArticlePubMed Google Scholar
Opal, S. M. et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a Phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit. Care Med.25, 1115–1124 (1997). ArticleCASPubMed Google Scholar
Stroke Therapy Academic Industry Roundtable II (STAIR-II). Recommendations for clinical trial evaluation of acute stroke therapies. Stroke32, 1598–1606 (2001).
Emsley, H. C. et al. A randomised Phase II study of interleukin-1 receptor antagonist in acute stroke patients. J. Neurol. Neurosurg. Psychiatry (in the press). The findings of the first clinical trial of IL-1RA for the treatment of patients who have suffered an acute stroke.
Springborg, J. B., Frederiksen, H. J., Eskesen, V. & Olsen, N. V. Trends in monitoring patients with aneurysmal subarachnoid haemorrhage. Br. J. Anaesth.94, 259–270 (2005). ArticleCASPubMed Google Scholar
Campbell, S. J. et al. CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury. FASEB J.17, 1168–1170 (2003). ArticleCASPubMed Google Scholar
Obal, F. Jr. et al. Interleukin 1α and an interleukin 1β fragment are somnogenic. Am. J. Physiol.259, R439–R446 (1990). ArticleCASPubMed Google Scholar
Fang, J., Wang, Y. & Krueger, J. M. Effects of interleukin-1β on sleep are mediated by the type I receptor. Am. J. Physiol.274, R655–R660 (1998). CASPubMed Google Scholar
Avital, A. et al. Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus13, 826–834 (2003). ArticleCASPubMed Google Scholar
Vamvakopoulos, J., Green, C. & Metcalfe, S. Genetic control of IL-1β bioactivity through differential regulation of the IL-1 receptor antagonist. Eur. J. Immunol.32, 2988–2996 (2002). ArticleCASPubMed Google Scholar
Francis, S. E. et al. Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease. Circulation99, 861–866 (1999). ArticleCASPubMed Google Scholar
Worrall, B. B. et al. Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis. Stroke34, 790–793 (2003). ArticleCASPubMed Google Scholar
Dominici, R. et al. Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α. Immunogenetics54, 82–86 (2002). ArticleCASPubMed Google Scholar
Um, J. Y. et al. Association of interleukin-1α gene polymorphism with cerebral infarction. Brain Res. Mol. Brain Res.115, 50–54 (2003). ArticleCASPubMed Google Scholar
Seripa, D. et al. Relevance of interleukin-1 receptor antagonist intron-2 polymorphism in ischemic stroke. Cerebrovasc. Dis.15, 276–281 (2003). ArticleCASPubMed Google Scholar
Lee, B. C. et al. Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-α genes, but not the interleukin-1β gene. Neurosci. Lett.357, 33–36 (2004). ArticleCASPubMed Google Scholar
Iacoviello, L. et al. Polymorphisms of the interleukin-1β gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro. Arterioscler. Thromb. Vasc. Biol.25, 222–227 (2005). ArticleCASPubMed Google Scholar
Cullup, H., Middleton, P. G., Duggan, G., Conn, J. S. & Dickinson, A. M. Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals. Clin. Exp. Immunol.137, 351–358 (2004). ArticleCASPubMedPubMed Central Google Scholar
Ooboshi, H., Ibayashi, S., Takada, J., Kumai, Y. & Iida, M. Brain ischemia as a potential target of gene therapy. Exp. Gerontol.38, 183–187 (2003). ArticleCASPubMed Google Scholar
Spera, P. A., Ellison, J. A., Feuerstein, G. Z. & Barone, F. C. IL-10 reduces rat brain injury following focal stroke. Neurosci. Lett.251, 189–192 (1998). ArticleCASPubMed Google Scholar
Molina-Holgado, F. et al. Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. J. Neurosci.23, 6470–6474 (2003). ArticleCASPubMed Google Scholar