Mitochondrial fission in apoptosis (original) (raw)
Osteryoung, K. W. & Nunnari, J. The division of endosymbiotic organelles. Science302, 1698–1704 (2003). ArticleCAS Google Scholar
Alexander, C. et al. OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nature Genet.26, 211–215 (2000). ArticleCAS Google Scholar
Delettre, C. et al. Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy. Nature Genet.26, 207–210 (2000). ArticleCAS Google Scholar
Griparic, L., van der Wel, N. N., Orozco, I. J., Peters, P. J. & van der Bliek, A. M. Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria. J. Biol. Chem.279, 18792–18798 (2004). ArticleCAS Google Scholar
Olichon, A. et al. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J. Biol. Chem.278, 7743–7746 (2003). ArticleCAS Google Scholar
Cipolat, S., Martins de Brito, O., Dal Zilio, B. & Scorrano, L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc. Natl Acad. Sci. USA101, 15927–15932 (2004). ArticleCAS Google Scholar
Delettre, C. et al. Mutation spectrum and splicing variants in the OPA1 gene. Hum. Genet.109, 584–591 (2001). ArticleCAS Google Scholar
Chen, H. et al. Mitofusins MFN1 and MFN2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol.160, 189–200 (2003). ArticleCAS Google Scholar
Rojo, M., Legros, F., Chateau, D. & Lombes, A. Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologues of the transmembrane GTPase Fzo. J. Cell Sci.115, 1663–1674 (2002). CASPubMed Google Scholar
Karbowski, M. et al. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and MFN2 during apoptosis. J. Cell Biol.159, 931–938 (2002). ArticleCAS Google Scholar
Koshiba, T. et al. Structural basis of mitochondrial tethering by mitofusin complexes. Science305, 858–862 (2004). ArticleCAS Google Scholar
Ishihara, N., Eura, Y. & Mihara, K. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J. Cell Sci.117, 6535–6546 (2004). ArticleCAS Google Scholar
Meeusen, S., McCaffery, J. M. & Nunnari, J. Mitochondrial fusion intermediates revealed in vitro. Science305, 1747–1752 (2004). ArticleCAS Google Scholar
Dohm, J. A., Lee, S. J., Hardwick, J. M., Hill, R. B. & Gittis, A. G. Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. Proteins54, 153–156 (2004). ArticleCAS Google Scholar
Suzuki, M., Jeong, S. Y., Karbowski, M., Youle, R. J. & Tjandra, N. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J. Mol. Biol.334, 445–458 (2003). ArticleCAS Google Scholar
Praefcke, G. J. & McMahon, H. T. The dynamin superfamily: universal membrane tubulation and fission molecules? Nature Rev. Mol. Cell Biol.5, 133–147 (2004). ArticleCAS Google Scholar
van der Bliek, A. M. A mitochondrial division apparatus takes shape. J. Cell Biol.151, F1–F4 (2000). ArticleCAS Google Scholar
Danino, D., Moon, K. H. & Hinshaw, J. E. Rapid constriction of lipid bilayers by the mechanochemical enzyme dynamin. J. Struct. Biol.147, 259–267 (2004). ArticleCAS Google Scholar
Yoon, Y., Pitts, K. R. & McNiven, M. A. Mammalian dynamin-like protein DLP1 tubulates membranes. Mol. Biol. Cell12, 2894–2905 (2001). ArticleCAS Google Scholar
Karbowski, M., Jeong, S. Y. & Youle, R. J. Endophilin B1 is required for the maintenance of mitochondrial morphology. J. Cell Biol.166, 1027–1039 (2004). ArticleCAS Google Scholar
Ringstad, N. et al. Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis. Neuron24, 143–154 (1999). ArticleCAS Google Scholar
Farsad, K. et al. Generation of high curvature membranes mediated by direct endophilin bilayer interactions. J. Cell Biol.155, 193–200 (2001). ArticleCAS Google Scholar
Takei, K., McPherson, P. S., Schmid, S. L. & De Camilli, P. Tubular membrane invaginations coated by dynamin rings are induced by GTP-γ S in nerve terminals. Nature374, 186–190 (1995). ArticleCAS Google Scholar
Smirnova, E., Griparic, L., Shurland, D. -L. & van der Bliek, A. M. Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol. Biol. Cell12, 2245–2256 (2001). ArticleCAS Google Scholar
Lee, Y. J., Jeong, S. Y., Karbowski, M., Smith, C. L. & Youle, R. J. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol. Biol. Cell15, 5001–5011 (2004). ArticleCAS Google Scholar
Peters, C., Baars, T. L., Buhler, S. & Mayer, A. Mutual control of membrane fission and fusion proteins. Cell119, 667–678 (2004). ArticleCAS Google Scholar
Koch, A., Schneider, G., Luers, G. H. & Schrader, M. Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1. J. Cell Sci.117, 3995–4006 (2004). ArticleCAS Google Scholar
Nishida, K. et al. Dynamic recruitment of dynamin for final mitochondrial severance in a primitive red alga. Proc. Natl Acad. Sci. USA100, 2146–2151 (2003). ArticleCAS Google Scholar
Legesse-Miller, A., Massol, R. H. & Kirchhausen, T. Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. Mol. Biol. Cell14, 1953–1963 (2003). ArticleCAS Google Scholar
Mancini, M. et al. Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line. J. Cell Biol.138, 449–469 (1997). ArticleCAS Google Scholar
Desagher, S. & Martinou, J. C. Mitochondria as the central control point of apoptosis. Trends Cell Biol.10, 369–377 (2000). ArticleCAS Google Scholar
Frank, S. et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell1, 515–525 (2001). ArticleCAS Google Scholar
Pinton, P. et al. The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J.20, 2690–2701 (2001). ArticleCAS Google Scholar
Jagasia, R., Grote, P., Westermann, B. & Conradt, B. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature433, 754–760 (2005). ArticleCAS Google Scholar
Capano, M. & Crompton, M. Biphasic translocation of Bax to mitochondria. Biochem. J.367, 169–178 (2002). ArticleCAS Google Scholar
Karbowski, M. et al. Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J. Cell Biol.164, 493–499 (2004). ArticleCAS Google Scholar
Breckenridge, D. G., Stojanovic, M., Marcellus, R. C. & Shore, G. C. Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J. Cell Biol.160, 1115–1127 (2003). ArticleCAS Google Scholar
Sugioka, R., Shimizu, S. & Tsujimoto, Y. Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis. J. Biol. Chem.279, 52726–52734 (2004). ArticleCAS Google Scholar
James, D. I., Parone, P. A., Mattenberger, Y. & Martinou, J. C. hFis1, a novel component of the mammalian mitochondrial fission machinery. J. Biol. Chem.278, 36373–36379 (2003). ArticleCAS Google Scholar
Fannjiang, Y. et al. Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev.18, 2785–2797 (2004). ArticleCAS Google Scholar
Schinzel, A. et al. Conformational control of Bax localization and apoptotic activity by Pro168. J. Cell Biol.164, 1021–1032 (2004). ArticleCAS Google Scholar
Nechushtan, A., Smith, C. L., Lamensdorf, I., Yoon, S.-H. & Youle, R. J. Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J. Cell Biol.153, 1265–1276 (2001). ArticleCAS Google Scholar
Valentijn, A. J., Metcalfe, A. D., Kott, J., Streuli, C. H. & Gilmore, A. P. Spatial and temporal changes in Bax subcellular localization during anoikis. J. Cell Biol.162, 599–612 (2003). ArticleCAS Google Scholar
Germain, M., Mathai, J. P., McBride, H. M. & Shore, G. C. Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. EMBO J.24, 1546–1556 (2005). ArticleCAS Google Scholar
Cuddeback, S. M. et al. Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax. J. Biol. Chem.276, 20559–20565 (2001). ArticleCAS Google Scholar
Pierrat, B. et al. SH3GLB, a new endophilin-related protein family featuring an SH3 domain. Genomics71, 222–234 (2001). ArticleCAS Google Scholar
Basanez, G. et al. Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature. J. Biol. Chem.277, 49360–49365 (2002). ArticleCAS Google Scholar
Scorrano, L. et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev. Cell2, 55–67 (2002). ArticleCAS Google Scholar
Olichon, A. et al. The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett.523, 171–176 (2002). ArticleCAS Google Scholar
Sesaki, H., Southard, S. M., Yaffe, M. P. & Jensen, R. E. Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol. Biol. Cell14, 2342–2356 (2003). ArticleCAS Google Scholar
Kuwana, T. et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell111, 331–342 (2002). ArticleCAS Google Scholar
Dorstyn, L., Mills, K., Lazebnik, Y. & Kumar, S. The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. J. Cell Biol.167, 405–410 (2004). ArticleCAS Google Scholar
Dimmer, K. S. et al. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol. Biol. Cell13, 847–853 (2002). ArticleCAS Google Scholar
Bleazard, W. et al. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nature Cell Biol.1, 298–304 (1999). ArticleCAS Google Scholar
Labrousse, A. M., Zappaterra, M. D., Rube, D. A. & van der Bliek, A. M. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol. Cell4, 815–826 (1999). ArticleCAS Google Scholar
Hales, K. G. & Fuller, M. T. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell90, 121–129 (1997). ArticleCAS Google Scholar
Shepard, K. A. & Yaffe, M. P. The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. J. Cell Biol.144, 711–720 (1999). ArticleCAS Google Scholar
Wong, E. D. et al. The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol.151, 341–352 (2000). ArticleCAS Google Scholar
Hermann, G. J. et al. Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell Biol.143, 359–373 (1998). ArticleCAS Google Scholar
Santel, A. & Fuller, M. Control of mitochondrial morphology by a human mitofusin. J. Cell Sci.114, 867–874 (2001). CASPubMed Google Scholar
Mozdy, A. D., McCaffery, J. M. & Shaw, J. M. Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol.151, 367–380 (2000). ArticleCAS Google Scholar
Yoon, Y., Krueger, E. W., Oswald, B. J. & McNiven, M. A. The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol. Cell. Biol.23, 5409–5420 (2003). ArticleCAS Google Scholar
Tieu, Q., Okreglak, V., Naylor, K. & Nunnari, J. The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission. J. Cell Biol.158, 445–452 (2002). ArticleCAS Google Scholar
Cerveny, K. L., McCaffery, J. M. & Jensen, R. E. Division of mitochondria requires a novel DNM1-interacting protein, Net2p. Mol. Biol. Cell12, 309–321 (2001). ArticleCAS Google Scholar
Messerschmitt, M. et al. The inner membrane protein Mdm33 controls mitochondrial morphology in yeast. J. Cell Biol.160, 553–564 (2003). ArticleCAS Google Scholar
Sesaki, H. & Jensen, R. E. UGO1 encodes an outer membrane protein required for mitochondrial fusion. J. Cell Biol.152, 1123–1134 (2001). ArticleCAS Google Scholar
Nemoto, Y. & De Camilli, P. Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein. EMBO J.18, 2991–3006 (1999). ArticleCAS Google Scholar
Frederick, R. L., McCaffery, J. M., Cunningham, K. W., Okamoto, K. & Shaw, J. M. Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J. Cell Biol.167, 87–98 (2004). ArticleCAS Google Scholar
Fransson, A., Ruusala, A. & Aspenstrom, P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J. Biol. Chem.278, 6495–6502 (2003). ArticleCAS Google Scholar
Alto, N. M., Soderling, J. & Scott, J. D. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J. Cell Biol.158, 659–668 (2002). ArticleCAS Google Scholar
Mukamel, Z. & Kimchi, A. Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death. J. Biol. Chem.279, 36732–36738 (2004). ArticleCAS Google Scholar
Harder, Z., Zunino, R. & McBride, H. Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission. Curr. Biol.14, 340–345 (2004). ArticleCAS Google Scholar
Tondera, D. et al. Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis. J. Biol. Chem.279, 31544–31555 (2004). ArticleCAS Google Scholar