Doomsday postponed? Preventing and reversing epidemics of drug-resistant tuberculosis (original) (raw)
Raviglione, M. C. & Uplekar, M. W. WHO's new stop TB strategy. Lancet367, 952–955 (2006). Article Google Scholar
World Health Organization. Anti-tuberculosis drug resistance in the world: report no. 3 (WHO, Geneva, 2004).
Singh, J. A., Upshur, R. & Padayatchi, N. XDR-TB in South Africa: no time for denial or complacency. PLoS Med.4, e50 (2007). Article Google Scholar
Koenig, R. Drug-resistant tuberculosis. In South Africa, XDR TB and HIV prove a deadly combination. Science319, 894–897 (2008). Article Google Scholar
Jones, K. D., Hesketh, T. & Yudkin, J. Extensively drug-resistant tuberculosis in sub-Saharan Africa: an emerging public-health concern. Trans. R. Soc. Trop. Med. Hyg.102, 219–224 (2008). Article Google Scholar
World Health Organization. Anti-tuberculosis drug resistance in the world: report no. 4 (WHO, Geneva, 2008).
von Gottberg, A. et al. Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study. Lancet371, 1108–1113 (2008). Article Google Scholar
Hancock, R. E. W. The end of an era? Nature Rev. Drug Discov.6, 28 (2007). ArticleCAS Google Scholar
Raviglione, M. XDR-TB: entering the post-antibiotic era? Int. J. Tuberc. Lung Dis.10, 1185–1187 (2006). PubMed Google Scholar
Norrby, S. R., Nord, C. E. & Finch, R. Lack of development of new antimicrobial drugs: a potential serious threat to public health. Lancet Infect. Dis.5, 115–119 (2005). Article Google Scholar
Levy, S. B. & Marshall, B. Antibacterial resistance worldwide: causes, challenges and responses. Nature Med.10, S122–S129 (2004). ArticleCAS Google Scholar
Spigelman, M. K. New tuberculosis therapeutics: a growing pipeline. J. Infect. Dis.196 (Suppl. 1), 28–34 (2007). Article Google Scholar
Glickman, S. W., Rasiel, E. B., Hamilton, C. D., Kubataev, A. & Schulman, K. A. A portfolio model of drug development for tuberculosis. Science311, 1246–1247 (2006). ArticleCAS Google Scholar
Dye, C. & Espinal, M. A. Will tuberculosis become resistant to all antibiotics? Proc. R. Soc. Lond. B268, 45–52 (2001). ArticleCAS Google Scholar
World Health Organization. The global MDR-TB and XDR-TB response plan 2007–2008 (WHO, Geneva, 2007).
Dye, C., Espinal, M. A., Watt, C. J., Mbiaga, C. & Williams, B. G. Worldwide incidence of multidrug-resistant tuberculosis. J. Infect. Dis.185, 1197–1202 (2002). Article Google Scholar
Zignol, M. et al. Global incidence of multidrug-resistant tuberculosis. J. Infect. Dis.194, 479–485 (2006). Article Google Scholar
Cohen, T. et al. Challenges in estimating the total burden of drug-resistant tuberculosis. Am. J. Respir. Crit. Care Med.177, 1302–1306 (2008). Article Google Scholar
Ben Amor, Y., Nemser, B., Singh, A., Sankin, A. & Schluger, N. Underreported threat of multidrug-resistant tuberculosis in Africa. Emerg. Infect. Dis.14, 1345–1352 (2008). Article Google Scholar
Shah, N. S. et al. Worldwide emergence of extensively drug-resistant tuberculosis. Emerg. Infect. Dis.13, 380–387 (2007). ArticleCAS Google Scholar
Pillay, M. & Sturm, A. W. Evolution of the extensively drug-resistant F15/LAM4/KZN strain of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa. Clin. Infect. Dis.45, 1409–1414 (2007). ArticleCAS Google Scholar
Gandhi, N. R. et al. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet368, 1575–1580 (2006). Article Google Scholar
Dye, C. & Espinal, M. A. Will tuberculosis become resistant to all antibiotics? Proc. R. Soc. Lond. B268, 45–52 (2001). ArticleCAS Google Scholar
Dye, C. & Williams, B. G. Criteria for the control of drug-resistant tuberculosis. Proc. Natl Acad. Sci. USA97, 8180–8185 (2000). ArticleCAS Google Scholar
Dye, C., Williams, B. G., Espinal, M. A. & Raviglione, M. C. Erasing the world's slow stain: strategies to beat multidrug-resistant tuberculosis. Science295, 2042–2046 (2002). ArticleCAS Google Scholar
Cohen, T., Sommers, B. & Murray, M. The effect of drug resistance on the fitness of Mycobacterium tuberculosis. Lancet Infect. Dis.3, 13–21 (2003). Article Google Scholar
Martinez, J. L., Baquero, F. & Andersson, D. I. Predicting antibiotic resistance. Nature Rev. Microbiol.5, 958–965 (2007). ArticleCAS Google Scholar
Rosas-Magallanes, V. et al. Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis. Mol. Biol. Evol.23, 1129–1135 (2006). ArticleCAS Google Scholar
Coros, A., DeConno, E. & Derbyshire, K. M. IS_6110_, a Mycobacterium tuberculosis complex-specific insertion sequence, is also present in the genome of Mycobacterium smegmatis, suggestive of lateral gene transfer among mycobacterial species. J. Bacteriol.190, 3408–3410 (2008). ArticleCAS Google Scholar
Becq, J. et al. Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli. Mol. Biol. Evol.24, 1861–1871 (2007). ArticleCAS Google Scholar
Hazbon, M. H. et al. Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis. Antimicrob. Agents Chemother.50, 2640–2649 (2006). ArticleCAS Google Scholar
Prammananan, T. et al. Distribution of rpoB mutations among multidrug-resistant Mycobacterium tuberculosis (MDRTB) strains from Thailand and development of a rapid method for mutation detection. Clin. Microbiol. Infect.14, 446–453 (2008). ArticleCAS Google Scholar
Caws, M. et al. The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLoS Pathog.4, e1000034 (2008). Article Google Scholar
Espinal, M. A. et al. Standard short-course chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countries. J. Am. Med. Assoc.283, 2537–2545 (2000). ArticleCAS Google Scholar
Mak, A. et al. Influence of multidrug resistance on tuberculosis treatment outcomes with standardized regimens. Am. J. Respir. Crit. Care Med.178, 306–312 (2008). Article Google Scholar
Cox, H. et al. Tuberculosis recurrence and mortality after successful treatment: impact of drug resistance. PLoS Med.3, e384 (2006). Article Google Scholar
Cox, H. S. et al. Risk of acquired drug resistance during short-course directly observed treatment of tuberculosis in an area with high levels of drug resistance. Clin. Infect. Dis.44, 1421–1427 (2007). ArticleCAS Google Scholar
Nathanson, E. et al. Multidrug-resistant tuberculosis management in resource-limited settings. Emerg. Infect. Dis.12, 1389–1397 (2006). Article Google Scholar
Leimane, V. et al. Clinical outcome of individualized treatment of multidrug-resistant tuberculosis in Latvia: a retrospective cohort study. Lancet365, 318–326 (2005). Article Google Scholar
Furin, J. The clinical management of drug-resistant tuberculosis. Curr. Opin. Pulm. Med.13, 212–217 (2007). ArticleCAS Google Scholar
Shin, S. S. et al. Long-term follow-up for multidrug-resistant tuberculosis. Emerg. Infect. Dis.12, 687–688 (2006). Article Google Scholar
Keshavjee, S. et al. Treatment of extensively drug-resistant tuberculosis in Tomsk, Russia: a retrospective cohort study. Lancet372, 1403–1409 (2008). Article Google Scholar
Mitnick, C. S. et al. Comprehensive treatment of extensively drug-resistant tuberculosis. N. Engl. J. Med.359, 563–574 (2008). ArticleCAS Google Scholar
World Health Organization. Global tuberculosis control 2008: surveillance, planning, financing (WHO, Geneva, 2008).
World Health Organization. Green Light Committee Initiative. Annual report (WHO, Geneva, 2007).
Kwon, Y. S. et al. Treatment outcomes for HIV-uninfected patients with multidrug-resistant and extensively drug-resistant tuberculosis. Clin. Infect. Dis.47, 496–502 (2008). Article Google Scholar
Bonilla, C. A. et al. Management of extensively drug-resistant tuberculosis in Peru: cure is possible. PLoS One3, e2957 (2008). PubMedPubMed Central Google Scholar
Cox, H. S., Morrow, M. & Deutschmann, P. W. Long term efficacy of DOTS regimens for tuberculosis: systematic review. Br. Med. J.336, 484–487 (2008). Article Google Scholar
Chan, E. D., Strand, M. J. & Iseman, M. D. Treatment outcomes in extensively resistant tuberculosis. N. Engl. J. Med.359, 657–659 (2008). ArticleCAS Google Scholar
Mariam, D. H., Mengistu, Y., Hoffner, S. E. & Andersson, D. I. Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis. Antimicrob. Agents Chemother.48, 1289–1294 (2004). ArticleCAS Google Scholar
Gagneux, S. et al. The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science312, 1944–1946 (2006). ArticleCAS Google Scholar
Strauss, O. J. et al. Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence. J. Clin. Microbiol.46, 1514–1516 (2008). ArticleCAS Google Scholar
European Concerted Action on New Generation Genetic Markers and Techniques for the Epidemiology and Control of Tuberculosis. Beijing/W genotype Mycobacterium tuberculosis and drug resistance. Emerg. Infect. Dis.12, 736–743 (2006).
Sun, Y. J. et al. Genotype and phenotype relationships and transmission analysis of drug-resistant tuberculosis in Singapore. Intern. J. Tuberc. Lung Dis.11, 436–442 (2007). Google Scholar
Cox, H. S. et al. The Beijing genotype and drug resistant tuberculosis in the Aral Sea region of Central Asia. Respir. Res.6, 134 (2005). Article Google Scholar
Marais, B. J. et al. Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape Province of South Africa. J. Clin. Microbiol.44, 3539–3543 (2006). ArticleCAS Google Scholar
Lopez, B. et al. A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes. Clin. Exper. Immunol.133, 30–37 (2003). ArticleCAS Google Scholar
Toungoussova, O. S., Caugant, D. A., Sandven, P., Mariandyshev, A. O. & Bjune, G. Impact of drug resistance on fitness of Mycobacterium tuberculosis strains of the W-Beijing genotype. FEMS Immunol. Med. Microbiol.42, 281–290 (2004). ArticleCAS Google Scholar
Blower, S. & Supervie, V. Predicting the future of XDR tuberculosis. Lancet Infect. Dis.7, 443 (2007). Article Google Scholar
Cohen, T. & Murray, M. Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness. Nature Med.10, 1117–1121 (2004). ArticleCAS Google Scholar
Blower, S. M. & Chou, T. Modeling the emergence of the 'hot zones': tuberculosis and the amplification dynamics of drug resistance. Nature Med.10, 1111–1116 (2004). ArticleCAS Google Scholar
DeRiemer, K. et al. Does DOTS work in populations with drug-resistant tuberculosis? Lancet365, 1239–1245 (2005). Article Google Scholar
Espinal, M. A. & Dye, C. Can DOTS control multidrug-resistant tuberculosis? Lancet365, 1206–1209 (2005). Article Google Scholar
Wu, P. et al. Age-period-cohort analysis of tuberculosis notifications in Hong Kong from 1961 to 2005. Thorax63, 312–316 (2008). ArticleCAS Google Scholar
Dye, C. in Clinical Tuberculosis 4th edn (eds Davies, P. D. O., Barnes, P. F. & Gordon, S. B.) 21–41 (Hodder Arnold, London, 2008). Google Scholar
Dye, C., Garnett, G. P., Sleeman, K. & Williams, B. G. Prospects for worldwide tuberculosis control under the WHO DOTS strategy. Directly observed short-course therapy. Lancet352, 1886–1891 (1998). ArticleCAS Google Scholar
Styblo, K. & Bumgarner, J. R. Tuberculosis can be controlled with existing technologies: evidence. Tubercul. Surveill. Res. Unit. Progress Report2, 60–72 (1991). Google Scholar
Nardell, E. A. Environmental infection control of tuberculosis. Semin. Respir. Infect.18, 307–319 (2003). Article Google Scholar
Bock, N. N., Jensen, P. A., Miller, B. & Nardell, E. Tuberculosis infection control in resource-limited settings in the era of expanding HIV care and treatment. J. Infect. Dis.196 (Suppl. 1), 108–113 (2007). Article Google Scholar
World Health Organization. Tuberculosis infection control in the era of expanding care and treatment (WHO, Geneva, 2007).
World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis (WHO, Geneva, 2006).
Cobelens, F. G. et al. Scaling up programmatic management of drug-resistant tuberculosis: a prioritized research agenda. PLoS Med.5, e150 (2008). Article Google Scholar
Mitnick, C. D., Appleton, S. C. & Shin, S. S. Epidemiology and treatment of multidrug resistant tuberculosis. Semin. Respir. Crit. Care Med.29, 499–524 (2008). Article Google Scholar
Nunn, A. J., Phillips, P. P. & Gillespie, S. H. Design issues in pivotal drug trials for drug sensitive tuberculosis (TB). Tuberculosis (Edinb.)88 (Suppl. 1), 85–92 (2008). Article Google Scholar
Borgdorff, M. W., Floyd, K. & Broekmans, J. F. Interventions to reduce tuberculosis mortality and transmission in low- and middle-income countries. Bull. World Health Organ.80, 217–227 (2002). PubMedPubMed Central Google Scholar
Styblo, K. Epidemiology of Tuberculosis (KNCV Tuberculosis Foundation, The Hague, 1991). Google Scholar
China Tuberculosis Control Collaboration. The effect of tuberculosis control in China. Lancet364, 417–422 (2004).
Dye, C., Ottmani, S., Laasri, L. & Bencheikh, N. The decline of tuberculosis epidemics under chemotherapy: a case study in Morocco. Int. J. Tuberc. Lung Dis.11, 1225–1231 (2007). CASPubMed Google Scholar
Suarez, P. G. et al. The dynamics of tuberculosis in response to 10 years of intensive control effort in Peru. J. Infect. Dis.184, 473–478 (2001). ArticleCAS Google Scholar