Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning (original) (raw)
Senior, K. Dosing in phase II trial of Alzheimer's vaccine suspended. Lancet Neurol.1, 3 (2002). Article Google Scholar
Tanzi, R. E. et al. The gene defects responsible for familial Alzheimer's disease. Neurobiol. Dis.3, 159–168 (1996). ArticleCAS Google Scholar
Hardy, J. New insights into the genetics of Alzheimer's disease. Ann. Med.28, 255–258 (1996). ArticleCAS Google Scholar
Citron, M. et al. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature360, 672–674 (1992). ArticleCAS Google Scholar
Citron, M. et al. Mutant presenilins of Alzheimer's disease increase production of 42 residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med.3, 67–72 (1997). ArticleCAS Google Scholar
Suzuki, N. et al. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (β APP717) mutants. Science264, 1336–1340 (1994). ArticleCAS Google Scholar
Borchelt, D. R. et al. Familial Alzheimer's disease-linked presenilin I variants elevate Aβ1–42/1–40 ratio in vitro and in vivo. Neuron17, 1005–1013 (1996). ArticleCAS Google Scholar
Scheuner, D. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med.2, 864–870 (1996). ArticleCAS Google Scholar
Schenk D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature400, 173–177 (1999). ArticleCAS Google Scholar
Janus, C. et al. A β peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature408, 979–982 (2000). ArticleCAS Google Scholar
Morgan, D. et al. A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature408, 982–985 (2000). ArticleCAS Google Scholar
Sigurdsson, E. M., Scholtzova, H., Mehta, P. D., Frangione, B. & Wisniewski, T. Immunization with a non-toxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am. J. Pathol.159, 439–447 (2001). ArticleCAS Google Scholar
Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease. Nature Med.6, 916–919 (2000). ArticleCAS Google Scholar
DeMattos, R. B. et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA98, 8850–8855 (2001). ArticleCAS Google Scholar
DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M. & Holtzman, D. M. Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science295, 2264–2267 (2002). ArticleCAS Google Scholar
Dodart, J. C. et al. Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model. Nature Neurosci.5, 452–457 (2002). ArticleCAS Google Scholar
Solomon, B., Koppel, R., Hanan, E. & Katzav, T. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer β-amyloid peptide. Proc. Natl Acad. Sci. USA93, 452–455 (1996). ArticleCAS Google Scholar
Solomon, B., Koppel, R., Frenkel, D. & Hanan-Aharon, E. Disaggregation of Alzheimer β-amyloid by site-directed mAb. Proc. Natl Acad. Sci. USA94, 4109–4112 (1997). ArticleCAS Google Scholar
Bacskai, B. et al. Non-Fc mediated mechanisms are involved in clearance of amyloid-β in vivo by immunotherapy. J. Neurosci.22, 7862–7872 (2002). Article Google Scholar
Frenkel, D., Katz, O. & Solomon, B. Immunization against Alzheimer's β-amyloid plaques via EFRH phage administration. Proc. Natl Acad. Sci. USA97, 11455–11459 (2000). ArticleCAS Google Scholar
Lopez, J. C. The comeback of immunization. Nature Rev. Neurosci.3, 330 (2002). ArticleCAS Google Scholar
Hock, C. Vaccination therapy for Alzheimer's disease. Neurobiol. Aging23, S143 (2002). Google Scholar
Monsonego, A. et al. Immunogenic aspects of amyloid β-peptide: implications for pathogenesis and treatment of Alzheimer's disease Neurobiol. Aging23, S112 (2002). Google Scholar