- Holick, M. F. Vitamin D deficiency. N. Engl. J. Med. 357, 266–281 (2007).
Article CAS PubMed Google Scholar
- Nykjaer, A. et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 96, 507–515 (1999).
Article CAS PubMed Google Scholar
- Zhong, Y., Armbrecht, H. J. & Christakos, S. Calcitonin, a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene. J. Biol. Chem. 284, 11059–11069 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Turunen, M. M., Dunlop, T. W., Carlberg, C. & Vaisanen, S. Selective use of multiple vitamin D response elements underlies the 1 alpha, 25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res. 35, 2734–2747 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Liu, S. et al. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J. Am. Soc. Nephrol. 17, 1305–1315 (2006).
Article CAS PubMed Google Scholar
- Urakawa, I. et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770–774 (2006).
Article CAS PubMed Google Scholar
- Shimada, T. et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J. Clin. Invest. 113, 561–568 (2004).
Article CAS PubMed PubMed Central Google Scholar
- Carlberg, C. & Seuter, S. A genomic perspective on vitamin D signaling. Anticancer Res. 29, 3485–3493 (2009).
CAS PubMed Google Scholar
- Christakos, S., Raval-Pandya, M., Wernyj, R. P. & Yang, W. Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3. Biochem. J. 316 (Pt 2), 361–371 (1996).
Article CAS PubMed PubMed Central Google Scholar
- Ginde, A. A., Liu, M. C. & Camargo, C. A. Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988–2004. Arch. Intern. Med. 169, 626–632 (2009).
Article CAS PubMed PubMed Central Google Scholar
- White, J. H. Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysis. J. Steroid Biochem. Mol. Biol. 89–90, 239–244 (2004).
Article CAS PubMed Google Scholar
- Bosse, Y., Maghni, K. & Hudson, T. J. 1alpha, 25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes. Physiol. Genomics 29, 161–168 (2007).
Article CAS PubMed Google Scholar
- Ellis, B. C., Gattoni-Celli, S., Mancia, A. & Kindy, M. S. The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin. Dev. Comp. Immunol. 33, 901–912 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Towsend, K. et al. Identification of VDR-responsive gene signatures in breast cancer cells. Oncology 71, 111–123 (2006).
Article CAS PubMed Google Scholar
- Wu-Wong, J. R., Nakane, M., Ma, J., Ruan, X. & Kroeger, P. E. VDR-mediated gene expression patterns in resting human coronary artery smooth muscle cells. J. Cell Biochem. 100, 1395–1405 (2007).
Article CAS PubMed Google Scholar
- Tan, X., Wen, X. & Liu, Y. Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J. Am. Soc. Nephrol. 19, 1741–1752 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Norman, A. W. Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 147, 5542–5548 (2006).
Article CAS PubMed Google Scholar
- Dusso, A. S., Brown, A. J. & Slatopolsky, E. Vitamin D. Am. J. Physiol. Renal Physiol. 289, F8–F28 (2005).
Article CAS PubMed Google Scholar
- Holick, M. F. & Garabedian, M. in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (ed. Favus, M. J.) 129–137 (Lippincott Williams & Wilkins, Washington, DC, 2006).
Google Scholar
- Holick, M. F. Resurrection of vitamin D deficiency and rickets. J. Clin. Invest. 116, 2062–2072 (2006).
Article CAS PubMed PubMed Central Google Scholar
- Kumar, R., Schaefer, J., Grande, J. P. & Roche, P. C. Immunolocalization of calcitriol receptor, 24-hydroxylase cytochrome P-450, and calbindin D28k in human kidney. Am. J. Physiol. 266, F477–F485 (1994).
CAS PubMed Google Scholar
- Zhang, Z. et al. 1,25-Dihydroxyvitamin D3 targeting of NF-kappaB suppresses high glucose-induced MCP-1 expression in mesangial cells. Kidney Int. 72, 193–201 (2007).
Article CAS PubMed Google Scholar
- Zhang, Z. et al. Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int. 73, 163–171 (2008).
Article CAS PubMed Google Scholar
- Vieth, R. The role of vitamin D in the prevention of osteoporosis. Ann. Med. 37, 278–285 (2005).
Article CAS PubMed Google Scholar
- Bischoff-Ferrari, H. A., Giovannucci, E., Willett, W. C., Dietrich, T. & Dawson-Hughes, B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am. J. Clin. Nutr. 84, 18–28 (2006).
Article CAS PubMed Google Scholar
- Lips, P. Which circulating level of 25-hydroxyvitamin D is appropriate? J. Steroid Biochem. Mol. Biol. 89–90, 611–614 (2004).
Article CAS PubMed Google Scholar
- Malabanan, A., Veronikis, I. E. & Holick, M. F. Redefining vitamin D insufficiency. Lancet 351, 805–806 (1998).
Article CAS PubMed Google Scholar
- Jones, G. Pharmacokinetics of vitamin D toxicity. Am. J. Clin. Nutr. 88, 582S–586S (2008).
Article CAS PubMed Google Scholar
- Matsuoka, L. Y., Ide, L., Wortsman, J., MacLaughlin, J. A. & Holick, M. F. Sunscreens suppress cutaneous vitamin D3 synthesis. J. Clin. Endocrinol. Metab. 64, 1165–1168 (1987).
Article CAS PubMed Google Scholar
- Scragg, R. & Camargo, C. A. Jr. Frequency of leisure-time physical activity and serum 25-hydroxyvitamin D levels in the US population: results from the Third National Health and Nutrition Examination Survey. Am. J. Epidemiol. 168, 577–586 (2008).
Article PubMed PubMed Central Google Scholar
- Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z. & Holick, M. F. Decreased bioavailability of vitamin D in obesity. Am. J. Clin. Nutr. 72, 690–693 (2000).
Article CAS PubMed Google Scholar
- Binkley, N. et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J. Clin. Endocrinol. Metab. 89, 3152–3157 (2004).
Article CAS PubMed Google Scholar
- Singh, R. J. Are clinical laboratories prepared for accurate testing of 25-hydroxy vitamin D? Clin. Chem. 54, 221–223 (2008).
Article CAS PubMed Google Scholar
- Yates, A. M. et al. Interlaboratory variation in 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 is significantly improved if common calibration material is used. Clin. Chem. 54, 2082–2084 (2008).
Article CAS PubMed Google Scholar
- Looker, A. C. et al. Serum 25-hydroxyvitamin D status of the US population: 1988–1994 compared with 2000–2004. Am. J. Clin. Nutr. 88, 1519–1527 (2008).
Article CAS PubMed Google Scholar
- Carter, G. D. 25-Hydroxyvitamin D assays: the quest for accuracy. Clin. Chem. 55, 1300–1302 (2009).
Article CAS PubMed Google Scholar
- Gonzalez, E. A., Sachdeva, A., Oliver, D. A. & Martin, K. J. Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study. Am. J. Nephrol. 24, 503–510 (2004).
Article CAS PubMed Google Scholar
- Jean, G., Charra, B. & Chazot, C. Vitamin D deficiency and associated factors in hemodialysis patients. J. Ren. Nutr. 18, 395–399 (2008).
Article PubMed Google Scholar
- LaClair, R. E. et al. Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States. Am. J. Kidney Dis. 45, 1026–1033 (2005).
Article CAS PubMed Google Scholar
- Levin, A. et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int. 71, 31–38 (2007).
Article CAS PubMed Google Scholar
- Barreto, D. V. et al. Vitamin D affects survival independently of vascular calcification in chronic kidney disease. Clin. J. Am. Soc. Nephrol. 4, 1128–1135 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Cuppari, L., Carvalho, A. B. & Draibe, S. A. Vitamin D status of chronic kidney disease patients living in a sunny country. J. Ren. Nutr. 18, 408–414 (2008).
Article PubMed Google Scholar
- Wolf, M. et al. Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int. 72, 1004–1013 (2007).
Article CAS PubMed Google Scholar
- Wang, A. Y. et al. Serum 25-hydroxyvitamin D status and cardiovascular outcomes in chronic peritoneal dialysis patients: a 3-y prospective cohort study. Am. J. Clin. Nutr. 87, 1631–1638 (2008).
Article CAS PubMed Google Scholar
- Zittermann, A., Gummert, J. F. & Borgermann, J. Vitamin D deficiency and mortality. Curr. Opin. Clin. Nutr. Metab. Care doi:10.1097/MCO.0b013e3283310767
Article CAS PubMed Google Scholar
- Autier, P. & Gandini, S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch. Intern. Med. 167, 1730–1737 (2007).
Article CAS PubMed Google Scholar
- Melamed, M. L., Michos, E. D., Post, W. & Astor, B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch. Intern. Med. 168, 1629–1637 (2008).
Article PubMed PubMed Central Google Scholar
- Wang, T. J. et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 117, 503–511 (2008).
Article CAS PubMed Google Scholar
- Dobnig, H. et al. Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Arch. Intern. Med. 168, 1340–1349 (2008).
Article CAS PubMed Google Scholar
- Hsia, J. et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation 115, 846–854 (2007).
Article CAS PubMed Google Scholar
- Wallis, D. E. & Penckofer, S. Letter by Wallis and Penckofer regarding article, “Calcium/vitamin D supplementation and cardiovascular events”. Circulation 116, e86 (2007).
Article CAS PubMed Google Scholar
- Pettifor, J. M. in Vitamin D (eds Feldman, D., Pike, J. W. & Glorieux, F. H.) 1065–1084 (Elsevier Academic Press, Boston, 2005).
Book Google Scholar
- Avenell, A., Gillespie, W. J., Gillespie, L. D. & O'Connell, D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database of Systematic Reviews Issue 2. Art. No.: CD000227 doi:10.1002/14651858.CD000227.pub3 (2009).
Google Scholar
- Tang, B. M., Eslick, G. D., Nowson, C., Smith, C. & Bensoussan, A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370, 657–666 (2007).
Article CAS PubMed Google Scholar
- Chapuy, M. C. et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N. Engl. J. Med. 327, 1637–1642 (1992).
Article CAS PubMed Google Scholar
- Dawson-Hughes, B., Harris, S. S., Krall, E. A. & Dallal, G. E. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N. Engl. J. Med. 337, 670–676 (1997).
Article CAS PubMed Google Scholar
- Grant, A. M. et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365, 1621–1628 (2005).
Article CAS PubMed Google Scholar
- de Boer, I. H., Ioannou, G. N., Kestenbaum, B., Brunzell, J. D. & Weiss, N. S. 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III). Am. J. Kidney Dis. 50, 69–77 (2007).
Article CAS PubMed Google Scholar
- Lambers Heerspink, H. J. et al. The Selective Vitamin D Receptor Activator for Albuminuria Lowering (VITAL) Study: study design and baseline characteristics. Am. J. Nephrol. 30, 280–286 (2009).
Article CAS PubMed Google Scholar
- Inaguma, D. et al. Relationship between serum 1,25-dihydroxyvitamin D and mortality in patients with pre-dialysis chronic kidney disease. Clin. Exp. Nephrol. 12, 126–131 (2008).
Article CAS PubMed Google Scholar
- Ravani, P. et al. Vitamin D levels and patient outcome in chronic kidney disease. Kidney Int. 75, 88–95 (2009).
Article CAS PubMed Google Scholar
- de Boer, I. et al. 25-Hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification. J. Am. Soc. Nephrol. 20, 1805–1812 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Chonchol, M. & Scragg, R. 25-Hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey. Kidney Int. 71, 134–139 (2007).
Article CAS PubMed Google Scholar
- Martins, D. et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch. Intern. Med. 167, 1159–1165 (2007).
Article CAS PubMed Google Scholar
- Marcen, R. et al. Prevalence of osteoporosis, osteopenia, and vertebral fractures in long-term renal transplant recipients. Transplant. Proc. 39, 2256–2258 (2007).
Article CAS PubMed Google Scholar
- Pichette, V. et al. Long-term bone loss in kidney transplant recipients: a cross-sectional and longitudinal study. Am. J. Kidney Dis. 28, 105–114 (1996).
Article CAS PubMed Google Scholar
- Kidney Disease Outcomes Quality Initiative Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease [online].
- Yuan, W. et al. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J. Biol. Chem. 282, 29821–29830 (2007).
Article CAS PubMed Google Scholar
- Tan, X., Li, Y. & Liu, Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. J. Am. Soc. Nephrol. 17, 3382–3393 (2006).
Article CAS PubMed Google Scholar
- Leheste, J. R. et al. Megalin knockout mice as an animal model of low molecular weight proteinuria. Am. J. Pathol. 155, 1361–1370 (1999).
Article CAS PubMed PubMed Central Google Scholar
- Leheste, J. R. et al. Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J. 17, 247–249 (2003).
Article CAS PubMed Google Scholar
- Matsui, I. et al. Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats. Nephrol. Dial. Transplant. 24, 2354–2361 (2009).
Article CAS PubMed Google Scholar
- Jacob, A. I., Sallman, A., Santiz, Z. & Hollis, B. W. Defective photoproduction of cholecalciferol in normal and uremic humans. J. Nutr. 114, 1313–1319 (1984).
Article CAS PubMed Google Scholar
- Andress, D. L. Vitamin D in chronic kidney disease: a systemic role for selective vitamin D receptor activation. Kidney Int. 69, 33–43 (2006).
Article CAS PubMed Google Scholar
- Li, Y., Spataro, B. C., Yang, J., Dai, C. & Liu, Y. 1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression. Kidney Int. 68, 1500–1510 (2005).
Article CAS PubMed Google Scholar
- Schwarz, U. et al. Effect of 1,25 (OH)2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats. Kidney Int. 53, 1696–1705 (1998).
Article CAS PubMed Google Scholar
- Xiao, H. et al. 1,25-Dihydroxyvitamin D(3) prevents puromycin aminonucleoside-induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-kinase/Akt-signaling pathway. Am. J. Nephrol. 30, 34–43 (2009).
Article CAS PubMed Google Scholar
- Okamura, M., Takano, Y., Saito, Y., Yao, J. & Kitamura, M. Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor. Nephrol. Dial. Transplant. 24, 3006–3012 (2009).
Article CAS PubMed Google Scholar
- Yamauchi, K. et al. Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes. Kidney Int. 70, 892–900 (2006).
Article CAS PubMed Google Scholar
- Wang, Y. et al. Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy. Kidney Int. 70, 882–891 (2006).
Article CAS PubMed Google Scholar
- Kuhlmann, A. et al. 1,25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat. Am. J. Physiol. Renal Physiol. 286, F526–F533 (2004).
Article CAS PubMed Google Scholar
- Li, Y. C. et al. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J. Clin. Invest. 110, 229–238 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Pilz, S., Tomaschitz, A., Ritz, E. & Pieber, T. R. Vitamin D status and arterial hypertension: a systematic review. Nat. Rev. Cardiol. 6, 621–630 (2009).
Article CAS PubMed Google Scholar
- Morris, K. L. & Zemel, M. B. 1,25-Dihydroxyvitamin D3 modulation of adipocyte glucocorticoid function. Obes. Res. 13, 670–677 (2005).
Article CAS PubMed Google Scholar
- de Borst, M. H. et al. Specific MAP-kinase blockade protects against renal damage in homozygous TGR(mRen2)27 rats. Lab. Invest. 83, 1761–1770 (2003).
Article CAS PubMed Google Scholar
- van Veldhuisen, D. J. et al. High- versus low-dose ACE inhibition in chronic heart failure: a double-blind, placebo-controlled study of imidapril. J. Am. Coll. Cardiol. 32, 1811–1818 (1998).
Article CAS PubMed Google Scholar
- Krikken, J. A., Laverman, G. D. & Navis, G. Benefits of dietary sodium restriction in the management of chronic kidney disease. Curr. Opin. Nephrol. Hypertens. doi:10.1097/MNH.0b013e3283312fc8
Article CAS PubMed Google Scholar
- Vogt, L., Waanders, F., Boomsma, F., de Zeeuw, D. & Navis, G. Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. J. Am. Soc. Nephrol. 19, 999–1007 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Kramer, A. B., van der Meulen, E. F., van Goor, H. & Navis, G. Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. Kidney Int. 71, 417–424 (2007).
Article CAS PubMed Google Scholar
- Nguyen, G. et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 109, 1417–1427 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Hamming, I., Navis, G., Kocks, M. J. & van Goor, H. ACE inhibition has adverse renal effects during dietary sodium restriction in proteinuric and healthy rats. J. Pathol. 209, 129–139 (2006).
Article CAS PubMed Google Scholar
- Mizobuchi, M. et al. Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats. J. Am. Soc. Nephrol. 18, 1796–1806 (2007).
Article CAS PubMed Google Scholar
- van Paassen, P., de Zeeuw, D., Navis, G. & de Jong, P. E. Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function. Nephrol. Dial. Transplant. 15, 637–643 (2000).
Article CAS PubMed Google Scholar
- Parving, H. H., Persson, F., Lewis, J. B., Lewis, E. J. & Hollenberg, N. K. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N. Engl. J. Med. 358, 2433–2446 (2008).
Article CAS PubMed Google Scholar
- Persson, F. et al. Renal effects of aliskiren compared to and in combination with irbesartan in patients with type 2 diabetes, hypertension and albuminuria. Diabetes Care 32, 1873–1879 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Yamamoto, E. et al. Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice. Hypertension 54, 633–638 (2009).
Article CAS PubMed Google Scholar
- Batenburg, W. W. et al. Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 28, 1151–1157 (2008).
Article CAS PubMed Google Scholar
- Zhang, Z. et al. Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase. Proc. Natl Acad. Sci. USA 105, 15896–15901 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Kramer, A. B., Laverman, G. D., van Goor, H. & Navis, G. Inter-individual differences in anti-proteinuric response to ACEi in established adriamycin nephrotic rats are predicted by pretreatment renal damage. J. Pathol. 201, 160–167 (2003).
Article CAS PubMed Google Scholar
- Remuzzi, G. et al. Combining an antiproteinuric approach with mycophenolate mofetil fully suppresses progressive nephropathy of experimental animals. J. Am. Soc. Nephrol. 10, 1542–1549 (1999).
CAS PubMed Google Scholar
- Panichi, V. et al. Effects of 1,25(OH)2D3 in experimental mesangial proliferative nephritis in rats. Kidney Int. 60, 87–95 (2001).
Article CAS PubMed Google Scholar
- Lemire, J. M., Adams, J. S., Sakai, R. & Jordan, S. C. 1 Alpha, 25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J. Clin. Invest. 74, 657–661 (1984).
Article CAS PubMed PubMed Central Google Scholar
- Rigby, W. F., Stacy, T. & Fanger, M. W. Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J. Clin. Invest. 74, 1451–1455 (1984).
Article CAS PubMed PubMed Central Google Scholar
- Adams, J. S. & Hewison, M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat. Clin. Pract. Endocrinol. Metab. 4, 80–90 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Zehnder, D. et al. Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation. Kidney Int. 74, 1343–1353 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Cohen-Lahav, M., Douvdevani, A., Chaimovitz, C. & Shany, S. The anti-inflammatory activity of 1,25-dihydroxyvitamin D3 in macrophages. J. Steroid Biochem. Mol. Biol. 103, 558–562 (2007).
Article CAS PubMed Google Scholar
- Sigmundsdottir, H. et al. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat. Immunol. 8, 285–293 (2007).
Article CAS PubMed Google Scholar
- Fritsche, J., Mondal, K., Ehrnsperger, A., Andreesen, R. & Kreutz, M. Regulation of 25-hydroxyvitamin D3–1 alpha-hydroxylase and production of 1 alpha, 25-dihydroxyvitamin D3 by human dendritic cells. Blood 102, 3314–3316 (2003).
Article CAS PubMed Google Scholar
- van Etten, E. & Mathieu, C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J. Steroid Biochem. Mol. Biol. 97, 93–101 (2005).
Article CAS PubMed Google Scholar
- Mora, J. R., Iwata, M. & von Andrian, U. H. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat. Rev. Immunol. 8, 685–698 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Penna, G. & Adorini, L. 1 Alpha, 25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J. Immunol. 164, 2405–2411 (2000).
Article CAS PubMed Google Scholar
- Adorini, L. & Penna, G. Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists. Hum. Immunol. 70, 345–352 (2009).
Article CAS PubMed Google Scholar
- Ghoreishi, M. et al. Expansion of antigen-specific regulatory T cells with the topical vitamin D analog calcipotriol. J. Immunol. 182, 6071–6078 (2009).
Article CAS PubMed Google Scholar
- Redaelli, C. A. et al. 1Alpha, 25-dihydroxyvitamin D3 shows strong and additive immunomodulatory effects with cyclosporine A in rat renal allotransplants. Kidney Int. 61, 288–296 (2002).
Article CAS PubMed Google Scholar
- Courbebaisse, M. et al. Effects of vitamin D supplementation on the calcium-phosphate balance in renal transplant patients. Kidney Int. 75, 646–651 (2009).
Article CAS PubMed Google Scholar
- Heymann, F. et al. Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J. Clin. Invest. 119, 1286–1297 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Thiem, U. et al. VITA-D: cholecalciferol substitution in vitamin D deficient kidney transplant recipients: a randomized, placebo-controlled study to evaluate the post-transplant outcome. Trials 10, 36 (2009).
Article CAS PubMed PubMed Central Google Scholar