Anti-CCP antibodies: the past, the present and the future (original) (raw)

• Schellekens, G. A., de Jong, B. A., van den Hoogen, F. H., van de Putte, L. B. & van Venrooij, W. J. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J. Clin. Invest. 101, 273–281 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Schellekens, G. A. et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 43, 155–163 (2000).
  Article CAS PubMed Google Scholar
• van Gaalen, F. A. et al. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheum. 50, 709–715 (2004).
  Article CAS PubMed Google Scholar
• Rantapaa-Dahlqvist, S. et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 48, 2741–2749 (2003).
  Article PubMed CAS Google Scholar
• van Venrooij, W. J., Zendman, A. J. & Pruijn, G. J. Autoantibodies to citrullinated antigens in (early) rheumatoid arthritis. Autoimmun. Rev. 6, 37–41 (2006).
  Article CAS PubMed Google Scholar
• Avouac, J., Gossec, L. & Dougados, M. Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann. Rheum. Dis. 65, 845–851 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Pruijn, G. J., Wiik, A. & van Venrooij, W. J. The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis. Arthritis Res. Ther. 12, 203 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• van der Woude, D. et al. Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis. Ann. Rheum. Dis. 69, 1554–1561 (2010).
  Article CAS PubMed Google Scholar
• Aletaha, D. et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62, 2569–2581 (2010).
  Article PubMed Google Scholar
• Neogi, T. et al. The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: phase 2 methodological report. Arthritis Rheum. 62, 2582–2591 (2010).
  Article PubMed PubMed Central Google Scholar
• van der Linden, M. P., Knevel, R., Huizinga, T. W. & van der Helm-van Mil, A. H. Classification of rheumatoid arthritis—comparison of the 1987 ACR and 2010 ACR/EULAR criteria. Arthritis Rheum. 63, 37–42 (2011).
  Article CAS PubMed Google Scholar
• Nienhuis, R. L. & Mandema, E. A new serum factor in patients with rheumatoid arthritis: the antiperinuclear factor. Ann. Rheum. Dis. 23, 302–305 (1964).
  Article CAS PubMed PubMed Central Google Scholar
• Dale, B. A., Holbrook, K. A., Kimball, J. R., Hoff, M. & Sun, T. T. Expression of epidermal keratins and filaggrin during human fetal skin development. J. Cell Biol. 101, 1257–1269 (1985).
  Article CAS PubMed Google Scholar
• Hoet, R. M., Boerbooms, A. M., Arends, M., Ruiter, D. J. & van Venrooij, W. J. Antiperinuclear factor, a marker autoantibody for rheumatoid arthritis: colocalisation of the perinuclear factor and profilaggrin. Ann. Rheum. Dis. 50, 611–618 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Hoet, R. M., Voorsmit, R. A. & van Venrooij, W. J. The perinuclear factor, a rheumatoid arthritis-specific autoantigen, is not present in keratohyalin granules of cultured buccal mucosa cells. Clin. Exp. Immunol. 84, 59–65 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Simon, M. et al. The cytokeratin filament-aggregating protein filaggrin is the target of the so-called “antikeratin antibodies,” autoantibodies specific for rheumatoid arthritis. J. Clin. Invest. 92, 1387–1393 (1993).
  Article CAS PubMed PubMed Central Google Scholar
• Sebbag, M. et al. The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies. J. Clin. Invest. 95, 2672–2679 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Girbal-Neuhauser, E. et al. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J. Immunol. 162, 585–594 (1999).
  CAS PubMed Google Scholar
• Vossenaar, E. R. & van Venrooij, W. J. Anti-CCP antibodies, a highly specific marker for (early) rheumatoid arthritis. Clin. Applied Immunol. Rev. 4, 239–262 (2004).
  Article CAS Google Scholar
• Wiik, A. S., van Venrooij, W. J. & Pruijn, G. J. All you wanted to know about anti-CCP but were afraid to ask. Autoimmun. Rev. 10, 90–93 (2010).
  Article CAS PubMed Google Scholar
• van Beers, J. J. B. C., Zendman, A. J. W., van Venrooij, W. J. & Pruijn, G. J. M. in From Etiopathogenesis to the Prediction of Autoimmune Diseases: Relevance of Autoantibodies: Report on the 8 th Dresden Symposium on Autoantibodies held in Dresden on September 12–15, 2007. Ch. 7 (eds Conrad, K. et al.) 378–388 (Pabst Science Publishers, Lengerich, 2007).
  Google Scholar
• Vossenaar, E. R. et al. The presence of citrullinated proteins is not specific for rheumatoid synovial tissue. Arthritis Rheum. 50, 3485–3494 (2004).
  Article CAS PubMed Google Scholar
• Klareskog, L., Catrina, A. I. & Paget, S. Rheumatoid arthritis. Lancet 373, 659–672 (2009).
  Article CAS PubMed Google Scholar
• Hill, J. A. et al. Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J. Immunol. 171, 538–541 (2003).
  Article CAS PubMed Google Scholar
• Hill, J. A. et al. Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J. Exp. Med. 205, 967–979 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• van der Woude, D. et al. Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations. Arthritis Rheum. 62, 1236–1245 (2010).
  Article CAS PubMed Google Scholar
• James, E. A. et al. HLA-DR1001 presents “altered-self” peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets. Arthritis Rheum. 62, 2909–2918 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Gyetvai, A. et al. New classification of the shared epitope in rheumatoid arthritis: impact on the production of various anti-citrullinated protein antibodies. Rheumatology (Oxford) 49, 25–33 (2010).
  Article CAS Google Scholar
• Berglin, E. et al. A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis. Arthritis Res. Ther. 6, R303–R308 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Klareskog, L., Wedren, S. & Alfredsson, L. On the origins of complex immune-mediated disease: the example of rheumatoid arthritis. J. Mol. Med. 87, 357–362 (2009).
  Article PubMed Google Scholar
• Bang, S. Y. et al. Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study. Arthritis Res. Ther. 12, R115 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• van Venrooij, W. J. & Pruijn, G. J. An important step towards completing the rheumatoid arthritis cycle. Arthritis Res. Ther. 10, 117 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• Klareskog, L., Ronnelid, J., Lundberg, K., Padyukov, L. & Alfredsson, L. Immunity to citrullinated proteins in rheumatoid arthritis. Annu. Rev. Immunol. 26, 651–675 (2008).
  Article CAS PubMed Google Scholar
• Bang, H. et al. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 56, 2503–2511 (2007).
  Article CAS PubMed Google Scholar
• Mathsson, L. et al. Antibodies against citrullinated vimentin in rheumatoid arthritis: higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides. Arthritis Rheum. 58, 36–45 (2008).
  Article CAS PubMed Google Scholar
• Vander Cruyssen, B. et al. Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays. Arthritis Res. Ther. 8, R122 (2006).
  Article PubMed PubMed Central CAS Google Scholar
• Bizzaro, N., Tonutti, E., Tozzoli, R. & Villalta, D. Analytical and diagnostic characteristics of 11 2nd- and 3rd-generation immunoenzymatic methods for the detection of antibodies to citrullinated proteins. Clin. Chem. 53, 1527–1533 (2007).
  Article CAS PubMed Google Scholar
• Coenen, D., Verschueren, P., Westhovens, R. & Bossuyt, X. Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis. Clin. Chem. 53, 498–504 (2007).
  Article CAS PubMed Google Scholar
• Dejaco, C. et al. Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis. Arthritis Res. Ther. 8, R119 (2006).
  Article PubMed PubMed Central CAS Google Scholar
• Mutlu, N. et al. Comparative performance analysis of 4 different anti-citrullinated protein assays in the diagnosis of rheumatoid arthritis. J. Rheumatol. 36, 491–500 (2009).
  Article PubMed Google Scholar
• Damjanovska, L. et al. Diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis. Ann. Rheum. Dis. 69, 730–732 (2010).
  Article CAS PubMed Google Scholar
• Innala, L. et al. Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides. J. Rheumatol. 35, 1002–1008 (2008).
  PubMed Google Scholar
• Soos, L. et al. Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis. J. Rheumatol. 34, 1658–1663 (2007).
  CAS PubMed Google Scholar
• Vander Cruyssen, B. et al. Do all anti-citrullinated protein/peptide antibody tests measure the same? Evaluation of discrepancy between anti-citrullinated protein/peptide antibody tests in patients with and without rheumatoid arthritis. Ann. Rheum. Dis. 67, 542–546 (2008).
  Article CAS PubMed Google Scholar
• van der Linden, M. P. et al. Towards a data-driven evaluation of the 2010 ACR/EULAR criteria for rheumatoid arthritis: is it sensible to look at levels of rheumatoid factor? Arthritis Rheum. 63, 1190–1199 (2011).
  Article CAS PubMed Google Scholar
• Jansen, L. M. et al. The predictive value of anti-cyclic citrullinated peptide antibodies in early arthritis. J. Rheumatol. 30, 1691–1695 (2003).
  CAS PubMed Google Scholar
• Snir, O. et al. Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles. Ann. Rheum. Dis. 68, 736–743 (2009).
  Article CAS PubMed Google Scholar
• Snir, O. et al. Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients. Arthritis Rheum. 62, 44–52 (2010).
  Article CAS PubMed Google Scholar
• Ioan-Facsinay, A. et al. Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities. Ann. Rheum. Dis. 70, 188–193 (2011).
  Article CAS PubMed Google Scholar
• Andrade, F. et al. Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation. Arthritis Rheum. 62, 1630–1640 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Halvorsen, E. H. et al. Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity. Ann. Rheum. Dis. 67, 414–417 (2008).
  Article CAS PubMed Google Scholar
• Halvorsen, EH. et al. Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agents. Ann. Rheum. Dis. 68, 249–252 (2009).
  Article CAS PubMed Google Scholar
• Kolfenbach, J. R. et al. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis Rheum. 62, 2633–2639 (2010).
  Article PubMed PubMed Central Google Scholar
• Ioan-Facsinay, A. et al. Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease. Arthritis Rheum. 58, 3000–3008 (2008).
  Article PubMed Google Scholar
• Schuerwegh, A. J. et al. Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis. Proc. Natl Acad. Sci. USA 107, 2586–2591 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Kokkonen, H. et al. Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis. Arthritis Res. Ther. 13, R13 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Vannini, A. et al. Anti-cyclic citrullinated peptide positivity in non-rheumatoid arthritis disease samples: citrulline-dependent or not? Ann. Rheum. Dis. 66, 511–516 (2007).
  Article CAS PubMed Google Scholar
• Kakumanu, P. et al. Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis. J. Rheumatol. 36, 2682–2690 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Elkayam, O. et al. The anti-cyclic citrullinated peptide response in tuberculosis patients is not citrulline-dependent and sensitive to treatment. Arthritis Res. Ther. 12, R12 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Kakumanu, P. et al. Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide. Arthritis Rheum. 58, 1576–1581 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Nielen, M. M. et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 50, 380–386 (2004).
  Article PubMed Google Scholar
• Berglin, E. et al. Radiological outcome in rheumatoid arthritis is predicted by presence of antibodies against cyclic citrullinated peptide before and at disease onset, and by IgA-RF at disease onset. Ann. Rheum. Dis. 65, 453–458 (2006).
  Article CAS PubMed Google Scholar
• Kallberg, H. et al. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am. J. Hum. Genet. 80, 867–875 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• van Beers, J. J. B. C., van Venrooij, W. J. & Pruijn, G. J. M. in From Pathogenesis to Therapy of Autoimmune Diseases: Autoantigens, Autoantibodies, Autoimmunity (eds Conrad, K. et al.) 265–278 (Pabst Science Publishers, Lengerich, 2009).
  Google Scholar
• van der Helm-van Mil, A. H. & Huizinga, T. W. Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res. Ther. 10, 205–212 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• Cader, M. Z., Filer, A. D., Buckley, C. D. & Raza, K. The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritis. BMC. Musculoskelet. Disord. 11, 187–191 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Pedersen, M. et al. Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides. Arthritis Res. Ther. 8, R133 (2006).
  Article PubMed PubMed Central CAS Google Scholar
• López-Longo, F. J., Sánchez-Ramón, S. & Carreño, L. The value of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: do they imply new risk factors? Drug News Perspect. 22, 543–548 (2009).
  Article PubMed Google Scholar
• van Dongen, H. et al. Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 56, 1424–1432 (2007).
  Article CAS PubMed Google Scholar
• Mikuls, T. R. et al. Anti-citrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione _S_-transferase in a cross-sectional study. Arthritis Res. Ther. 12, R213 (2010).
  Article PubMed PubMed Central Google Scholar
• Kallberg, H. et al. Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke. Ann. Rheum. Dis. 70, 508–511 (2011).
  Article PubMed Google Scholar
• Bang, S. Y. et al. Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status. Arthritis Rheum. 62, 369–377 (2010).
  CAS PubMed Google Scholar
• Vossenaar, E. R. & van Venrooij, W. J. Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis. Arthritis Res. Ther. 6, 107–111 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Bos, W. H., Dijkmans, B. A., Boers, M., van de Stadt, R. J. & van Schaardenburg, D. Effect of dexamethasone on autoantibody levels and arthritis development in patients with arthralgia: a randomised trial. Ann. Rheum. Dis. 69, 571–574 (2010).
  Article CAS PubMed Google Scholar
• Mjaavatten, M. D. et al. The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis. Arthritis Res. Ther. 12, R76 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Kuhn, K. A. et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J. Clin. Invest. 116, 961–973 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Uysal, H. et al. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J. Exp. Med. 206, 449–462 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Ho, P. P. et al. Autoimmunity against fibrinogen mediates inflammatory arthritis in mice. J. Immunol. 184, 379–390 (2010).
  Article CAS PubMed Google Scholar
• Clavel, C. et al. Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum. 58, 678–688 (2008).
  Article CAS PubMed Google Scholar
• van Oosterhout, M. et al. Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis. Arthritis Rheum. 58, 53–60 (2008).
  Article CAS PubMed Google Scholar
• Trouw, L. A. et al. Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis Rheum. 60, 1923–1931 (2009).
  Article CAS PubMed Google Scholar
• Sokolove, J., Zhao, X., Chandra, P. E. & Robinson, W. H. Immune complexes containing citrullinated fibrinogen co-stimulate macrophages via Toll-like receptor 4 and Fcγ receptor. Arthritis Rheum. 63, 53–62 (2010).
  Article CAS Google Scholar
• Mahdi, H. et al. Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis. Nat. Genet. 41, 1319–1324 (2009).
  Article CAS PubMed Google Scholar
• Visser, K. et al. A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: post hoc analyses from the BeSt study. Ann. Rheum. Dis. 69, 1333–1337 (2010).
  Article CAS PubMed Google Scholar
• Wegner, N. et al. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum. 62, 2662–2672 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Mangat, P., Wegner, N., Venables, P. J. & Potempa, J. Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res. Ther. 12, 209–217 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Edwards, J. C. & Cambridge, G. Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology (Oxford) 40, 205–211 (2001).
  Article CAS Google Scholar
• Cambridge, G. et al. Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis. Arthritis Rheum. 48, 2146–2154 (2003).
  Article PubMed Google Scholar
• Vossenaar, E. R., Zendman, A. J., van Venrooij, W. J. & Pruijn, G. J. PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioessays 25, 1106–1118 (2003).
  Article CAS PubMed Google Scholar