Characteristics and clinical significance of histological variants of bladder cancer (original) (raw)
References
Wasco, M. J. et al. Urothelial carcinoma with divergent histologic differentiation (mixed histologic features) predicts the presence of locally advanced bladder cancer when detected at transurethral resection. Urology70, 69–74 (2007). PubMed Google Scholar
Cai, T. et al. Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens. Urology84, 1141–1146 (2014). PubMed Google Scholar
International Agency for Research on Cancer. WHO Classification of Tumours of the Urinary System and Male Genital Organs (eds Moch, H., Humphrey, P. A., Ulbright, T. M. & Reueter, V. E.) (WHO, 2016).
Shah, R. B., Montgomery, J. S., Montie, J. E. & Kunju, L. P. Variant (divergent) histologic differentiation in urothelial carcinoma is under-recognized in community practice: impact of mandatory central pathology review at a large referral hospital. Urol. Oncol.31, 1650–1655 (2013). PubMed Google Scholar
Monn, M. F. et al. Contemporary bladder cancer: variant histology may be a significant driver of disease. Urol. Oncol.33, 18.e15–18.e20 (2015). Google Scholar
Kaimakliotis, H. Z. et al. Plasmacytoid variant urothelial bladder cancer: is it time to update the treatment paradigm? Urol. Oncol.32, 833–838 (2014). PubMed Google Scholar
Babjuk, M. et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016. Eur. Urol.71, 447–461 (2017). PubMed Google Scholar
Alfred Witjes, J. et al. Updated 2016 EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur. Urol.71, 462–475 (2016). PubMed Google Scholar
Humphrey, P. A., Moch, H., Cubilla, A. L., Ulbright, T. M. & Reuter, V. E. The 2016 WHO classification of tumours of the urinary system and male genital organs-part B: prostate and bladder tumours. Eur. Urol.70, 106–119 (2016). PubMed Google Scholar
Rice, K. R. et al. Lymph node metastases in patients with urothelial carcinoma variants: influence of the specific variant on nodal histology. Urol. Oncol.33, 20.e23–20.e29 (2015). Google Scholar
Abol-Enein, H., Kava, B. R. & Carmack, A. J. K. Nonurothelial cancer of the bladder. Urology69, 93–104 (2007). PubMed Google Scholar
Felix, A. S. et al. The changing patterns of bladder cancer in Egypt over the past 26 years. Cancer Causes Control19, 421–429 (2008). PubMedPubMed Central Google Scholar
Guo, C. C. et al. Squamous cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 16 cases. Hum. Pathol.40, 1448–1452 (2009). CASPubMed Google Scholar
Lopez-Beltran, A. & Cheng, L. Histologic variants of urothelial carcinoma: differential diagnosis and clinical implications. Hum. Pathol.37, 1371–1388 (2006). CASPubMed Google Scholar
Ehdaie, B. et al. Comparative outcomes of pure squamous cell carcinoma and urothelial carcinoma with squamous differentiation in patients treated with radical cystectomy. J. Urol.187, 74–79 (2012). PubMed Google Scholar
Lagwinski, N. et al. Squamous cell carcinoma of the bladder: a clinicopathologic analysis of 45 cases. Am. J. Surg. Pathol.31, 1777–1787 (2007). PubMed Google Scholar
Rambau, P., Chalya, P. L. & Jackson, K. Schistosomiasis and urinary bladder cancer in North Western Tanzania: a retrospective review of 185 patients. Infecti. Agents Cancer8, 19 (2013). Google Scholar
Salem, H. K. & Mahfouz, S. Changing patterns (age, incidence, and pathologic types) of schistosoma-associated bladder cancer in Egypt in the past decade. Urology79, 379–383 (2012). PubMed Google Scholar
Mouli, S., Casalino, D. D. & Nikolaidis, P. Imaging features of common and uncommon bladder neoplasms. Radiol. Clin. North Amer.50, 301–316 (2012). Google Scholar
Gaisa, N. T. et al. Different immunohistochemical and ultrastructural phenotypes of squamous differentiation in bladder cancer. Virchows Archiv: Int. J. Pathol.458, 301–312 (2011). CAS Google Scholar
el-Mekresh, M. M., el-Baz, M. A., Abol-Enein, H. & Ghoneim, M. A. Primary adenocarcinoma of the urinary bladder: a report of 185 cases. Br. J. Urol.82, 206–212 (1998). CASPubMed Google Scholar
Zaghloul, M. S. et al. Long-term results of primary adenocarcinoma of the urinary bladder: a report on 192 patients. Urol. Oncol.24, 13–20 (2006). PubMed Google Scholar
Grignon, D. J., Ro, J. Y., Ayala, A. G., Johnson, D. E. & Ordóñez, N. G. Primary adenocarcinoma of the urinary bladder. A clinicopathologic analysis of 72 cases. Cancer67, 2165–2172 (1991). CASPubMed Google Scholar
Grignon, D. J., Ro, J. Y., Ayala, A. G. & Johnson, D. E. Primary signet-ring cell carcinoma of the urinary bladder. Am. J. Clin. Pathol.95, 13–20 (1991). CASPubMed Google Scholar
Amin, M. B. Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. Mod. Pathol.22 (Suppl. 2), S96–S118 (2009). PubMed Google Scholar
Kim, S. P. et al. The impact of squamous and glandular differentiation on survival after radical cystectomy for urothelial carcinoma. J. Urol.188, 405–409 (2012). PubMed Google Scholar
Purnell, S., Sidana, A., Maruf, M., Grant, C. & Agarwal, P. K. Genitourinary paraganglioma: demographic, pathologic, and clinical characteristics in the surveillance, epidemiology, and end results database. Urol. Oncol.35, 457.e9–457.e14 (2017). Google Scholar
Sved, P., Gomez, P., Manoharan, M., Civantos, F. & Soloway, M. S. Small cell carcinoma of the bladder. BJU Int.94, 12–17 (2004). PubMed Google Scholar
Ploeg, M. et al. Clinical epidemiology of nonurothelial bladder cancer: analysis of the Netherlands Cancer Registry. J. Urol.183, 915–920 (2010). PubMed Google Scholar
Koay, E. J., Teh, B. S., Paulino, A. C. & Butler, E. B. A. Surveillance, epidemiology, and end results analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends. Cancer117, 5325–5333 (2011). PubMed Google Scholar
Abrahams, N. A., Moran, C., Reyes, A. O., Siefker-Radtke, A. & Ayala, A. G. Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases. Histopathology46, 57–63 (2005). CASPubMed Google Scholar
Abbas, F., Civantos, F., Benedetto, P. & Soloway, M. S. Small cell carcinoma of the bladder and prostate. URL46, 617–630 (1995). CAS Google Scholar
Choong, N. W. W., Quevedo, J. F. & Kaur, J. S. Small cell carcinoma of the urinary bladder. The Mayo Clinic experience. Cancer103, 1172–1178 (2005). PubMed Google Scholar
Mukesh, M., Cook, N., Hollingdale, A. E., Ainsworth, N. L. & Russell, S. G. Small cell carcinoma of the urinary bladder: a 15-year retrospective review of treatment and survival in the Anglian Cancer Network. BJU Int.103, 747–752 (2009). CASPubMed Google Scholar
Trias, I. et al. Small cell carcinoma of the urinary bladder. Presentation of 23 cases and review of 134 published cases. Eur. Urol.39, 85–90 (2001). CASPubMed Google Scholar
Cheng, L. et al. Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients. Cancer101, 957–962 (2004). PubMed Google Scholar
Quek, M. L. et al. Radical cystectomy for primary neuroendocrine tumors of the bladder: the university of southern california experience. J. Urol.174, 93–96 (2005). PubMed Google Scholar
Siefker-Radtke, A. O. et al. Evidence supporting preoperative chemotherapy for small cell carcinoma of the bladder: a retrospective review of the M. D. Anderson cancer experience. J. Urol.172, 481–484 (2004). PubMed Google Scholar
Compérat, E. et al. Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases. Pathology42, 650–654 (2010). PubMed Google Scholar
Kamat, A. M. et al. Micropapillary bladder cancer: a review of the University of Texas M. D. Anderson Cancer Center experience with 100 consecutive patients. Cancer110, 62–67 (2007). PubMed Google Scholar
Amin, M. B. et al. Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary serous carcinoma. Am. J. Surg. Pathol.18, 1224–1232 (1994). CASPubMed Google Scholar
Sangoi, A. R. et al. Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists. Am. J. Surg. Pathol.34, 1367–1376 (2010). PubMed Google Scholar
Guo, C. C. et al. Gene expression profile of the clinically aggressive micropapillary variant of bladder cancer. Eur. Urol.70, 611–620 (2016). CASPubMedPubMed Central Google Scholar
Watts, K. E. & Hansel, D. E. Emerging concepts in micropapillary urothelial carcinoma. Adv. Anatom. Pathol.17, 182–186 (2010). Google Scholar
Summerhayes, I. C. et al. Clinical and pathological characteristics of micropapillary transitional cell carcinoma: a highly aggressive variant. J. Urol.163, 748–751 (2000). PubMed Google Scholar
Kamat, A. M. et al. The case for early cystectomy in the treatment of nonmuscle invasive micropapillary bladder carcinoma. J. Urol.175, 881–885 (2006). PubMed Google Scholar
Sui, W. et al. Micropapillary bladder cancer: insights from the National Cancer Database. Bladder Cancer2, 415–423 (2016). PubMedPubMed Central Google Scholar
Spaliviero, M. et al. Clinical outcome of patients with T1 micropapillary urothelial carcinoma of the bladder. J. Urol.192, 702–707 (2014). PubMedPubMed Central Google Scholar
Willis, D. L. et al. Micropapillary bladder cancer: current treatment patterns and review of the literature. Urol. Oncol.32, 826–832 (2014). PubMedPubMed Central Google Scholar
Wright, J. L. et al. Differences in survival among patients with sarcomatoid carcinoma, carcinosarcoma and urothelial carcinoma of the bladder. J. Urol.178, 2302–2306 (2007). PubMed Google Scholar
Cheng, L. et al. Sarcomatoid carcinoma of the urinary bladder: the final common pathway of urothelial carcinoma dedifferentiation. Am. J. Surg. Pathol.35, e34–e46 (2011). PubMed Google Scholar
Jones, E. C. & Young, R. H. Myxoid and sclerosing sarcomatoid transitional cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 25 cases. Mod. Pathol.10, 908–916 (1997). CASPubMed Google Scholar
Gronau, S. et al. Immunohistomorphologic and molecular cytogenetic analysis of a carcinosarcoma of the urinary bladder. Virchows Arch.440, 436–440 (2002). PubMed Google Scholar
Lopez-Beltran, A., Luque, R. J., Mazzucchelli, R., Scarpelli, M. & Montironi, R. Changes produced in the urothelium by traditional and newer therapeutic procedures for bladder cancer. J. Clin. Pathol.55, 641–647 (2002). CASPubMedPubMed Central Google Scholar
Mukhopadhyay, S., Shrimpton, A. E., Jones, L. A., Nsouli, I. S. & Abraham, N. Z. Carcinosarcoma of the urinary bladder following cyclophosphamide therapy: evidence for monoclonal origin and chromosome 9p allelic loss. Arch. Pathol. Lab. Med.128, e8–e11 (2004). PubMed Google Scholar
Stamatiou, K. et al. Sarcomatoid carcinoma of the urinary bladder: a clinicopathological study of 4 cases and a review of the literature. Kor. J. Urol.51, 724–728 (2010). Google Scholar
Wang, J., Wang, F. W., Lagrange, C. A., Hemstreet Iii, G. P. & Kessinger, A. Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases. Sarcoma2010, 454792 (2010). PubMedPubMed Central Google Scholar
Malla, M., Wang, J. F., Trepeta, R., Feng, A. & Wang, J. Sarcomatoid carcinoma of the urinary bladder. Clin. Genitourinary Cancer14, 366–372 (2016). Google Scholar
Moschini, M. et al. Incidence and effect of variant histology on oncological outcomes in patients with bladder cancer treated with radical cystectomy. Urol. Oncol.35, 335–341 (2017). PubMed Google Scholar
Lopez-Beltran, A., Requena, M. J., Montironi, R., Blanca, A. & Cheng, L. Plasmacytoid urothelial carcinoma of the bladder. Hum. Pathol.40, 1023–1028 (2009). PubMed Google Scholar
Dayyani, F. et al. Plasmacytoid urothelial carcinoma, a chemosensitive cancer with poor prognosis, and peritoneal carcinomatosis. J. Urol.189, 1656–1661 (2013). PubMed Google Scholar
Kaimakliotis, H. Z. et al. Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes. Urology83, 1112–1116 (2014). PubMed Google Scholar
Ricardo-Gonzalez, R. R. et al. Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread. J. Urol.187, 852–855 (2012). PubMed Google Scholar
Keck, B. et al. Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy. BMC Cancer13, 71 (2013). CASPubMedPubMed Central Google Scholar
Amin, M. B. et al. Lymphoepithelioma-like carcinoma of the urinary bladder. Am. J. Surg. Pathol.18, 466–473 (1994). CASPubMed Google Scholar
Fadare, O., Renshaw, I. L. & Rubin, C. Pleomorphic lymphoepithelioma-like carcinoma of the urinary bladder. Int. J. Clin. Exp. Pathol.2, 194–199 (2009). PubMed Google Scholar
Lopez-Beltran, A. et al. Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. Virchows Archiv: Int. J. Pathol.438, 552–557 (2001). CAS Google Scholar
Williamson, S. R. et al. Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. Am. J. Surg. Pathol.35, 474–483 (2011). PubMed Google Scholar
Pantelides, N. et al. Lymphoepithelioma-like carcinoma of the urinary bladder: a case report and review of systemic treatment options. Urol. Ann.4, 45 (2012). PubMedPubMed Central Google Scholar
Talbert, M. L. & Young, R. H. Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. Am. J. Surg. Pathol.13, 374–381 (1989). CASPubMed Google Scholar
Young, R. H. & Oliva, E. Transitional cell carcinomas of the urinary bladder that may be underdiagnosed. A report of four invasive cases exemplifying the homology between neoplastic and non-neoplastic transitional cell lesions. Am. J. Surg. Pathol.20, 1448–1454 (1996). CASPubMed Google Scholar
Beltran, A. L. et al. Clinicopathological characteristics and outcome of nested carcinoma of the urinary bladder. Virchows Arch.465, 199–205 (2014). PubMed Google Scholar
Cox, R. & Epstein, J. I. Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. Am. J. Surg. Pathol.35, 1337–1342 (2011). PubMed Google Scholar
Holmang, S. & Johansson, S. L. The nested variant of transitional cell carcinoma—a rare neoplasm with poor prognosis. Scand. J. Urol. Nephrol.35, 102–105 (2001). CASPubMed Google Scholar
Wasco, M. J., Daignault, S., Bradley, D. & Shah, R. B. Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed cases. Hum. Pathol.41, 163–171 (2010). PubMed Google Scholar
Linder, B. J. et al. Outcomes following radical cystectomy for nested variant of urothelial carcinoma: a matched cohort analysis. J. Urol.189, 1670–1675 (2013). PubMed Google Scholar
Young, R. H. & Zukerberg, L. R. Microcystic transitional cell carcinomas of the urinary bladder. A report of four cases. Am. J. Clin. Pathol.96, 635–639 (1991). CASPubMed Google Scholar
Lopez-Beltran, A., Montironi, R. & Cheng, L. Microcystic urothelial carcinoma: morphology, immunohistochemistry and clinical behaviour. Histopathology64, 872–879 (2014). PubMed Google Scholar
Mai, K. T., Hakim, S. W., Ball, C. G., Flood, T. A. & Belanger, E. C. Nested and microcystic variants of urothelial carcinoma displaying immunohistochemical features of basal-like urothelial cells: an immunohistochemical and histopathogenetic study. Pathol. Int.64, 375–381 (2014). CASPubMed Google Scholar
Lopez-Beltran, A., Blanca, A., Montironi, R., Cheng, L. & Regueiro, J. C. Pleomorphic giant cell carcinoma of the urinary bladder. Hum. Pathol.40, 1461–1466 (2009). CASPubMed Google Scholar
Moch, H., Cubilla, A. L., Humphrey, P. A., Reuter, V. E. & Ulbright, T. M. The 2016 WHO classification of tumours of the urinary system and male genital organs-part A: renal, penile, and testicular tumours. Eur. Urol.70, 93–105 (2016). PubMed Google Scholar
Lopez-Beltran, A. et al. Urothelial carcinoma of the bladder, lipid cell variant: clinicopathologic findings and LOH analysis. Am. J. Surg. Pathol.34, 371–376 (2010). PubMed Google Scholar
Kojima, Y. et al. A case of urothelial carcinoma, lipid cell variant. Pathol. Int.63, 183–187 (2013). PubMed Google Scholar
Yamashita, R., Yamaguchi, R., Yuen, K., Niwakawa, M. & Tobisu, K. Urothelial carcinoma (clear cell variant) diagnosed with useful immunohistochemistry stain. Int. J. Urol.13, 1448–1450 (2006). PubMed Google Scholar
Rotellini, M., Fondi, C., Paglierani, M., Stomaci, N. & Raspollini, M. R. Clear cell carcinoma of the bladder in a patient with a earlier clear cell renal cell carcinoma: a case report with morphologic, immunohistochemical, and cytogenetical analysis. Appl. Immunohistochem. Mol. Morphol.18, 396–399 (2010). Google Scholar
Young, R. H. & Scully, R. E. Clear cell adenocarcinoma of the bladder and urethra. A report of three cases and review of the literature. Am. J. Surg. Pathol.9, 816–826 (1985). CASPubMed Google Scholar
Venyo, A. K.-G. Primary clear cell carcinoma of the urinary bladder. Int. Scholarly Res. Notices2014, 1–15 (2014). Google Scholar
Adeniran, A. J. & Tamboli, P. Clear cell adenocarcinoma of the urinary bladder: a short review. Arch. Pathol. Lab. Med.133, 987–991 (2009). PubMed Google Scholar
Moschini, M. et al. Pure but not mixed histologic variants are associated with poor survival at radical cystectomy in bladder cancer patients. Clin. Genitourin. Cancerhttp://dx.doi.org/10.1016/j.clgc.2016.12.006 (2016).
Manunta, A., Vincendeau, S., Kiriakou, G., Lobel, B. & Guillé, F. Non-transitional cell bladder carcinomas. BJU Int.95, 497–502 (2005). PubMed Google Scholar
Izard, J. P. et al. Outcomes of squamous histology in bladder cancer: a population-based study. Urol. Oncol.33, 425.e7–425.e13 (2015). Google Scholar
Kantor, A. F., Hartge, P., Hoover, R. N. & Fraumeni, J. F. Epidemiological characteristics of squamous cell carcinoma and adenocarcinoma of the bladder. Cancer Res.48, 3853–3855 (1988). CASPubMed Google Scholar
Scosyrev, E., Yao, J. & Messing, E. Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? Urology73, 822–827 (2009). PubMed Google Scholar
Abdollah, F. et al. Survival after radical cystectomy of non-bilharzial squamous cell carcinoma versus urothelial carcinoma: a competing-risks analysis. BJU Int.109, 564–569 (2012). PubMed Google Scholar
Williamson, S. R., Lopez-Beltran, A., Montironi, R. & Cheng, L. Glandular lesions of the urinary bladder:clinical significance and differential diagnosis. Histopathology58, 811–834 (2011). PubMed Google Scholar
Galsky, M. D. et al. Prospective trial of ifosfamide, paclitaxel, and cisplatin in patients with advanced non-transitional cell carcinoma of the urothelial tract. Urology69, 255–259 (2007). PubMed Google Scholar
Lughezzani, G. et al. Adenocarcinoma versus urothelial carcinoma of the urinary bladder: comparison between pathologic stage at radical cystectomy and cancer-specific mortality. Urology75, 376–381 (2010). PubMed Google Scholar
Mills, S. E. et al. Small cell undifferentiated carcinoma of the urinary bladder. A light-microscopic, immunocytochemical, and ultrastructural study of 12 cases. Am. J. Surg. Pathol.11, 606–617 (1987). CASPubMed Google Scholar
Soria, F. et al. HER2 overexpression is associated with worse outcomes in patients with upper tract urothelial carcinoma (UTUC). World J. Urol.35, 251–259 (2016). PubMed Google Scholar
Ross, J. S. et al. A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma. Clin. Cancer Res.20, 68–75 (2014). CASPubMed Google Scholar
Ching, C. B. et al. HER2 gene amplification occurs frequently in the micropapillary variant of urothelial carcinoma: analysis by dual-color in situ hybridization. Mod. Pathol24, 1111–1119 (2011). CASPubMed Google Scholar
Kim, B. et al. HER2 protein overexpression and gene amplification in plasmacytoid urothelial carcinoma of the urinary bladder. Dis. Markers2016, 8463731–8463736 (2016). PubMedPubMed Central Google Scholar
Schneider, S. A. et al. Outcome of patients with micropapillary urothelial carcinoma following radical cystectomy: ERBB2 (HER2) amplification identifies patients with poor outcome. Mod. Pathol.27, 758–764 (2014). CASPubMed Google Scholar
de Martino, M. et al. Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib. Cancer Biol. Ther.15, 1239–1247 (2014). CASPubMedPubMed Central Google Scholar
Wülfing, C. et al. A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma. Cancer115, 2881–2890 (2009). PubMed Google Scholar
Lim, M. G., Adsay, N. V., Grignon, D. J. & Osunkoya, A. O. E-Cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma. Mod. Pathol.24, 241–247 (2011). CASPubMed Google Scholar
Al-Ahmadie, H. A. et al. Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer. Nat. Genet.48, 356–358 (2016). CASPubMedPubMed Central Google Scholar
Fong, A. et al. Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. Am. J. Clin. Pathol.120, 93–100 (2003). CASPubMed Google Scholar
Babjuk, M. et al. EAU guidelines non-muscle-invasive urothelial carcinoma bladder: update 2013. Eur. Urol.64, 639–653 (2013). PubMed Google Scholar
Abd El-Latif, A., Watts, K. E., Elson, P., Fergany, A. & Hansel, D. E. The sensitivity of initial transurethral resection or biopsy of bladder tumor(s) for detecting bladder cancer variants on radical cystectomy. J. Urol.189, 1263–1267 (2013). PubMed Google Scholar
Weizer, A. Z. et al. Multiple adverse histological features increase the odds of under staging T1 bladder cancer. J. Urol.182, 59–65 (2009). PubMed Google Scholar
Ge, P., Wang, Z.-C., Yu, X., Lin, J. & He, Q. Sensitivity of initial biopsy or transurethral resection of bladder tumor(s) for detecting histological variants on radical cystectomy. BMC Urol.15, 46 (2015). PubMedPubMed Central Google Scholar
Burger, M. et al. Photodynamic diagnosis of non-muscle-invasive bladder cancer with hexaminolevulinate cystoscopy: a meta-analysis of detection and recurrence based on raw data. Eur. Urol.64, 846–854 (2013). PubMed Google Scholar
Naito, S. et al. The clinical research office of the endourological society (CROES) multicentre randomised trial of narrow band imaging-assisted transurethral resection of bladder tumour (TURBT) versus conventional white light imaging-assisted TURBT in primary non-muscle-invasive bladder cancer patients: trial protocol and 1-year results. Eur. Urol.70, 506–515 (2016). PubMed Google Scholar
Shapur, N. K. et al. Is radical cystectomy mandatory in every patient with variant histology of bladder cancer. Rare Tumors3, e22 (2011). PubMedPubMed Central Google Scholar
Gofrit, O. N. et al. The response of variant histology bladder cancer to intravesical immunotherapy compared to conventional cancer. Front. Oncol.6, 43 (2016). PubMedPubMed Central Google Scholar
Willis, D. L. et al. Clinical outcomes of cT1 micropapillary bladder cancer. J. Urol.193, 1129–1134 (2015). PubMed Google Scholar
Ghoneim, I. A. et al. Neoadjuvant systemic therapy or early cystectomy? Single-center analysis of outcomes after therapy for patients with clinically localized micropapillary urothelial carcinoma of the bladder. Urology77, 867–870 (2011). PubMed Google Scholar
Vourganti, S. et al. Low grade micropapillary urothelial carcinoma, does it exist? - Analysis of management and outcomes from the Surveillance, Epidemiology and End Results (SEER) Database. J. Cancer4, 336–342 (2013). CASPubMedPubMed Central Google Scholar
Miller, J. S. & Epstein, J. I. Noninvasive urothelial carcinoma of the bladder with glandular differentiation: report of 24 cases. Am. J. Surg. Pathol.33, 1241–1248 (2009). PubMed Google Scholar
Chan, T. Y. & Epstein, J. I. In situ adenocarcinoma of the bladder. Am. J. Surg. Pathol.25, 892–899 (2001). CASPubMed Google Scholar
Seisen, T., Compérat, E., Léon, P. & Rouprêt, M. Impact of histological variants on the outcomes of nonmuscle invasive bladder cancer after transurethral resection. Curr. Opin. Urol.24, 524–531 (2014). PubMed Google Scholar
Bansal, A., Kumar, N. & Sharma, S. C. Sarcomatoid variant of urothelial carcinoma of the urinary bladder. J. Cancer Res. Ther.9, 571–573 (2016). Google Scholar
Fatima, N. et al. Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases. Can. J. Urol.22, 7783–7787 (2015). PubMed Google Scholar
Raspollini, M. R. et al. Plasmacytoid urothelial carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of a case series. Hum. Pathol.42, 1149–1158 (2011). CASPubMed Google Scholar
Xylinas, E. et al. Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy. Eur. J. Cancer.49, 1889–1897 (2013). PubMed Google Scholar
Fairey, A. S. et al. Impact of micropapillary urothelial carcinoma variant histology on survival after radical cystectomy. Urol. Oncol.32, 110–116 (2014). PubMed Google Scholar
Monn, M. F. et al. The changing reality of urothelial bladder cancer: should non-squamous variant histology be managed as a distinct clinical entity? BJU Int.116, 236–240 (2015). PubMed Google Scholar
Ismaili, N. A rare bladder cancer - small cell carcinoma: review and update. Orphanet J. Rare Diseases6, 75 (2011). Google Scholar
Grossman, H. B. et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N. Engl. J. Med.349, 859–866 (2003). CASPubMed Google Scholar
International Collaboration of Trialists. International phase III trial assessing neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: long-term results of the BA06 30894 trial. J. Clin. Oncol.29, 2171–2177 (2011).
Pokuri, V. K. et al. Predictors of complete pathologic response (pT0) to neoadjuvant chemotherapy in muscle-invasive bladder carcinoma. Clin. Genitourinary Cancer14, e59–e65 (2016). Google Scholar
Culp, S. H. et al. Refining patient selection for neoadjuvant chemotherapy before radical cystectomy. J. Urol.191, 40–47 (2014). PubMed Google Scholar
Moschini, M. et al. Validation of preoperative risk grouping of the selection of patients most likely to benefit from neoadjuvant chemotherapy before radical cystectomy. Clin. GenitourinaryCancer15, e267–e273 (2016). Google Scholar
Black, P. C., Brown, G. A. & Dinney, C. P. N. The impact of variant histology on the outcome of bladder cancer treated with curative intent. Urol. Oncol.27, 3–7 (2009). PubMed Google Scholar
Meeks, J. J. et al. Pathological response to neoadjuvant chemotherapy for muscle-invasive micropapillary bladder cancer. BJU Int.111, E325–E330 (2013). PubMed Google Scholar
Kassouf, W. et al. Outcome and patterns of recurrence of nonbilharzial pure squamous cell carcinoma of the bladder: a contemporary review of the university of Texas M. D. Anderson cancer center experience. Cancer110, 764–769 (2007). PubMed Google Scholar
Gad el Mawla, N. et al. A randomized pilot study of high-dose epirubicin as neoadjuvant chemotherapy in the treatment of cancer of the bilharzial bladder. Ann. Oncol.2, 137–140 (1991). CASPubMed Google Scholar
Scosyrev, E. et al. Do mixed histological features affect survival benefit from neoadjuvant platinum-based combination chemotherapy in patients with locally advanced bladder cancer? A secondary analysis of Southwest Oncology Group-Directed Intergroup Study (S8710). BJU Int.108, 693–699 (2011). CASPubMed Google Scholar
Lynch, S. P. et al. Neoadjuvant chemotherapy in small cell urothelial cancer improves pathologic downstaging and long-term outcomes: results from a retrospective study at the MD Anderson Cancer Center. Eur. Urol.64, 307–313 (2013). PubMed Google Scholar
Siefker-Radtke, A. O. et al. Phase II clinical trial of neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin in small-cell urothelial cancer. J. Clin. Oncol.27, 2592–2597 (2009). CASPubMedPubMed Central Google Scholar
Bex, A., de Vries, R., Pos, F., Kerst, M. & Horenblas, S. Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. World J. Urol.27, 101–106 (2009). PubMed Google Scholar
Schreiber, D. et al. Characterization and outcomes of small cell carcinoma of the bladder using the surveillance, epidemiology, and end results database. Am. J. Clin. Oncol.36, 126–131 (2013). PubMed Google Scholar
Masson-Lecomte, A. et al. Oncological outcomes of advanced muscle-invasive bladder cancer with a micropapillary variant after radical cystectomy and adjuvant platinum-based chemotherapy. World J. Urol.33, 1087–1093 (2015). CASPubMed Google Scholar
Sui, W. et al. Contemporary treatment patterns and outcomes of sarcomatoid bladder cancer. World J. Urol.35, 1055–1061 (2016). PubMed Google Scholar
Willis, D. L., Porten, S. P. & Kamat, A. M. Should histologic variants alter definitive treatment of bladder cancer? Curr. Opin. Urol.23, 435–443 (2013). PubMed Google Scholar