The structure and function of MCM from archaeal M. Thermoautotrophicum (original) (raw)

References

1. Diffley, J.F. & Cocker, J.H. Protein–DNA interactions at a yeast replication origin. Nature 357, 169–172 (1992).
   Article CAS PubMed Google Scholar
2. Walter, J. & Newport, J.W. Regulation of replicon size in Xenopus egg extracts. Science 275, 993–995 (1997).
   Article CAS PubMed Google Scholar
3. Aparicio, O.M., Weinstein, D.M. & Bell, S.P. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91, 59–69 (1997).
   Article CAS PubMed Google Scholar
4. Chong, J.P., Mahbubani, H.M., Khoo, C.Y. & Blow, J.J. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375, 418–421 (1995).
   Article CAS PubMed Google Scholar
5. Kubota, Y., Mimura, S., Nishimoto, S., Takisawa, H. & Nojima, H. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 81, 601–609 (1995).
   Article CAS PubMed Google Scholar
6. Maiorano, D., Moreau, J. & Mechali, M. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature 404, 622–625 (2000).
   Article CAS PubMed Google Scholar
7. Tanaka, T., Knapp, D. & Nasmyth, K. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90, 649–660 (1997).
   Article CAS PubMed Google Scholar
8. Yan, H., Merchant, A.M. & Tye, B.K. Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes Dev. 7, 2149–2160 (1993).
   Article CAS PubMed Google Scholar
9. Ishimi, Y. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J. Biol. Chem. 272, 24508–24513 (1997).
   Article CAS PubMed Google Scholar
10. Labib, K., Tercero, J.A. & Diffley, J.F. Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 288, 1643–1647 (2000).
    Article CAS PubMed Google Scholar
11. Lee, J.K. & Hurwitz, J. Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures. Proc. Natl. Acad. Sci. USA 98, 54–59 (2001).
    Article CAS PubMed PubMed Central Google Scholar
12. Lei, M. & Tye, B.K. Initiating DNA synthesis: from recruiting to activating the MCM complex. J. Cell. Sci. 114, 1447–1454 (2001).
    CAS PubMed Google Scholar
13. Labib, K. & Diffley, J.F. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Curr. Opin. Genet. Dev. 11, 64–70 (2001).
    Article CAS PubMed Google Scholar
14. Tye, B.K. MCM proteins in DNA replication. Annu. Rev. Biochem. 68, 649–686 (1999).
    Article CAS PubMed Google Scholar
15. Patel, S.S. & Picha, K.M. Structure and function of hexameric helicases. Annu. Rev. Biochem. 69, 651–697 (2000).
    Article CAS PubMed Google Scholar
16. Schwacha, A. & Bell, S.P. Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication. Mol. Cell 8, 1093–1104 (2001).
    Article CAS PubMed Google Scholar
17. Kelman, Z., Lee, J.K. & Hurwitz, J. The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum ΔH contains DNA helicase activity. Proc. Natl. Acad. Sci. USA 96, 14783–14788 (1999).
    Article CAS PubMed PubMed Central Google Scholar
18. Shechter, D.F., Ying, C.Y. & Gautier, J. The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum ΔH minichromosome maintenance protein. J. Biol. Chem. 275, 15049–15059 (2000).
    Article CAS PubMed Google Scholar
19. Chong, J.P., Hayashi, M.K., Simon, M.N., Xu, R.M. & Stillman, B. A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase. Proc. Natl. Acad. Sci. USA 97, 1530–1535 (2000).
    Article CAS PubMed PubMed Central Google Scholar
20. Weinreich, M., Liang, C. & Stillman, B. The Cdc6p nucleotide-binding motif is required for loading MCM proteins onto chromatin. Proc. Natl. Acad. Sci. USA 96, 441–446 (1999).
    Article CAS PubMed PubMed Central Google Scholar
21. Grabowski, B. & Kelman, Z. Autophosphorylation of archaeal Cdc6 homologues is regulated by DNA. J. Bacteriol. 183, 5459–5464 (2001).
    Article CAS PubMed PubMed Central Google Scholar
22. Simmons, D.T. SV40 large T antigen functions in DNA replication and transformation. Adv. Virus. Res. 55, 75–134 (2000).
    Article CAS PubMed Google Scholar
23. Singleton, M.R., Sawaya, M.R., Ellenberger, T. & Wigley, D.B. Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides. Cell 101, 589–600 (2000).
    Article CAS PubMed Google Scholar
24. Kearsey, S.E. & Labib, K. MCM proteins: evolution, properties, and role in DNA replication. Biochim. Biophys. Acta 1398, 113–136 (1998).
    Article CAS PubMed Google Scholar
25. Hardy, C.F., Dryga, O., Seematter, S., Pahl, P.M. & Sclafani, R.A. mcm5/_cdc46_-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc. Natl. Acad. Sci. USA 94, 3151–3155 (1997).
    Article CAS PubMed PubMed Central Google Scholar
26. Valle, M., Gruss, C., Halmer, L., Carazo, J.M. & Donate, L.E. Large T-antigen double hexamers imaged at the simian virus 40 origin of replication. Mol. Cell. Biol. 20, 34–41 (2000).
    Article CAS PubMed PubMed Central Google Scholar
27. Fanning, E. & Knippers, R. Structure and function of simian virus 40 large tumor antigen. Annu. Rev. Biochem. 61, 55–85 (1992).
    Article CAS PubMed Google Scholar
28. Edwards, M.C. et al. MCM2-7 complexes bind chromatin in a distributed pattern surrounding ORC in Xenopus egg extracts. J. Biol. Chem. 277, 33049–33057 (2002).
    Article CAS PubMed Google Scholar
29. Bochkarev, A., Bochkareva, E., Frappier, L. & Edwards, A.M. The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding. EMBO J. 18, 4498–4504 (1999).
    Article CAS PubMed PubMed Central Google Scholar
30. Poplawski, A., Grabowski, B., Long, S.E. & Kelman, Z. The zinc finger domain of the archaeal minichromosome maintenance protein is required for helicase activity. J. Biol. Chem. 276, 49371–49377 (2001).
    Article CAS PubMed Google Scholar
31. Yu, X. et al. The Methanobacterium thermoautotrophicum MCM protein can form heptameric rings. EMBO Rep. 3, 792–797 (2002).
    Article PubMed PubMed Central Google Scholar
32. Smelkova, N.V. & Borowiec, J.A. Dimerization of simian virus 40 T antigen hexamers activates T-antigen DNA helicase activity. J. Virol. 71, 8766–8773 (1997).
    CAS PubMed PubMed Central Google Scholar
33. Gulbis, J.M., Kelman, Z., Hurwitz, J., O'Donnell, M. & Kuriyan, J. Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell 87, 297–306 (1996).
    Article CAS PubMed Google Scholar
34. Mauguen, Y. et al. Molecular structure of a new family of ribonucleases. Nature 297, 162–164 (1982).
    Article CAS PubMed Google Scholar
35. Spiller, B., Gershenson, A., Arnold, F.H. & Stevens, R.C. A structural view of evolutionary divergence. Proc. Natl. Acad. Sci. USA 96, 12305–12310 (1999).
    Article CAS PubMed PubMed Central Google Scholar
36. Le Du, M.H., Stigbrand, T., Taussig, M.J., Menez, A. & Stura, E.A. Crystal structure of alkaline phosphatase from human placenta at 1.8 Å resolution. Implication for a substrate specificity. J. Biol. Chem. 276, 9158–9165 (2001).
    Article CAS PubMed Google Scholar
37. Dalton, S. & Hopwood, B. Characterization of Cdc47p-minichromosome maintenance complexes in Saccharomyces cerevisiae: identification of Cdc45p as a subunit. Mol. Cell. Biol. 17, 5867–5875 (1997).
    Article CAS PubMed PubMed Central Google Scholar
38. Lei, M. et al. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev. 11, 3365–3374 (1997).
    Article CAS PubMed PubMed Central Google Scholar
39. Jones, T.A., Zou, J.Y. & Cowen, S.W. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110–119 (1990).
    Article Google Scholar
40. Brunger, A.T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905–921 (1998).
    Article CAS PubMed Google Scholar
41. Aiyar, A., Xiang, Y. & Leis, J. Site-directed mutagenesis using overlap extension PCR. Methods Mol. Biol. 57, 177–191 (1996).
    CAS PubMed Google Scholar
42. Rothstein, R. Disruption, replacement and allele rescue: integrative DNA transformation in yeast. in Guide to Yeast Genetics and Molecular Biology (ed. Guthrie, C. & Fink, G.) 281–301 (Academic Press, San Diego; 1991).
    Chapter Google Scholar
43. Sclafani, R.A., Tecklenburg, M. & Pierce, A. The mcm5-bob1 bypass of Cdc7p/Dbf4p in DNA replication depends on both Cdk1-independent and Cdk1-dependent steps in Saccharomyces cerevisiae. Genetics 161, 47–57 (2002).
    CAS PubMed PubMed Central Google Scholar
44. Kraulis, P.J. MOLSCRIPT — a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946–950 (1991).
    Article Google Scholar
45. Nicholls, A., Sharp, K.A. & Honig, B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281–296 (1991).
    Article CAS PubMed Google Scholar

Download references