Kinase cogs go forward and reverse in the Wnt signaling machine (original) (raw)

News & Views
Published: 01 January 2006

Nature Structural & Molecular Biology volume 13, pages 9–11 (2006)Cite this article

152 Accesses
10 Citations
Metrics details

An important link between Wnt binding at the cell surface and nuclear β-catenin–TCF–dependent transcription has been made with the identification of kinases that promote the association of the Wnt receptor and β-catenin turnover complexes. Surprisingly, the enzymes implicated had previously been suggested to inhibit rather than promote Wnt signaling.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$259.00 per year

only $21.58 per issue

Buy this article

Purchase on SpringerLink
Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

References

Davidson, G. et al. Nature 438, 867–872 (2005).
Article CAS Google Scholar
Zeng, X. et al. Nature 438, 873–877 (2005).
Article CAS Google Scholar
Schwarz-Romond, T. et al. Genes Dev. 16, 2073–2084 (2002).
Article CAS Google Scholar
Logan, C.Y. & Nusse, R. Annu. Rev. Cell Dev. Biol. 20, 781–810 (2004).
Article CAS Google Scholar
Ding, Y. & Dale, T. Trends Biochem. Sci. 27, 327–329 (2002).
Article CAS Google Scholar
Knippschild, U. et al. Cell. Signal. 17, 675–689 (2005).
Article CAS Google Scholar
Liu, C. et al. Cell 108, 837–847 (2002).
Article CAS Google Scholar
Amit, S. et al. Genes Dev. 16, 1066–1076 (2002).
Article CAS Google Scholar
Yanagawa, S. et al. EMBO J. 21, 1733–1742 (2002).
Article CAS Google Scholar
Cong, F., Schweizer, L. & Varmus, H. Mol. Cell. Biol. 24, 2000–2011 (2004).
Article CAS Google Scholar
Tamai, K. et al. Mol. Cell 13, 149–156 (2004).
Article CAS Google Scholar
He, X., Semenov, M., Tamai, K. & Zeng, X. Development 131, 1663–1677 (2004).
Article CAS Google Scholar
Marin, O. et al. Proc. Natl. Acad. Sci. USA 100, 10193–10200 (2003).
Article CAS Google Scholar
Mao, J. et al. Mol. Cell 7, 801–809 (2001).
Article CAS Google Scholar
Wong, H.C. et al. Mol. Cell 12, 1251–1260 (2003).
Article CAS Google Scholar
Tamai, K. et al. Nature 407, 530–535 (2000).
Article CAS Google Scholar
Cong, F. & Varmus, H. Development 131, 5103–5108 (2004).
Article CAS Google Scholar
Chen, W. et al. Science 301, 1391–1394 (2003).
Article CAS Google Scholar
Castellone, M.D., Teramoto, H., Williams, B.O., Druey, K.M. & Gutkind, J.S. Science 310, 1504–1510 (2005).
Article CAS Google Scholar
Liu, X., Rubin, J.S. & Kimmel, A.R. Curr. Biol. 15, 1989–1997 (2005).
Article CAS Google Scholar
Swiatek, W. et al. J. Biol. Chem. 279, 13011–13017 (2004).
Article CAS Google Scholar
Cliffe, A., Hamada, F. & Bienz, M. Curr. Biol. 13, 960–966 (2003).
Article CAS Google Scholar