Lloyd, R.S. & Van Houten, B . DNA damage recognition. in DNA Repair Mechanisms: Impact on Human Diseases and Cancer (ed. Vos, J.-M.) 25–66 (R.G. Landes Company, Biomedical Publishers, Austin, Texas, 1995). Google Scholar
Goosen, N. & Moolenaar, G.F. Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair. Res. Microbiol.152, 401–409 (2001). ArticleCAS Google Scholar
Theis, K. et al. The nucleotide excision repair protein UvrB, a helicase-like enzyme with a catch. Mutat. Res.460, 277–300 (2000). ArticleCAS Google Scholar
Verhoeven, E.E., Wyman, C., Moolenaar, G.F. & Goosen, N. The presence of two UvrB subunits in the UvrAB complex ensures damage detection in both DNA strands. EMBO J.21, 4196–4205 (2002). ArticleCAS Google Scholar
Orren, D.K. & Sancar, A. Formation and enzymatic properties of the UvrB-DNA complex. J. Biol. Chem.265, 15796–15803 (1990). CASPubMed Google Scholar
Skorvaga, M., Theis, K., Mandavilli, B.S., Kisker, C. & Van Houten, B. The beta-hairpin motif of UvrB is essential for DNA binding, damage processing, and UvrC-mediated incisions. J. Biol. Chem.277, 1553–1559 (2002). ArticleCAS Google Scholar
Lin, J.-J. & Sancar, A. Active site of (A)BC excinuclease: I. Evidence for 5′ incision by UvrC through a catalytic site involving Asp399, Asp438, and His538 residues. J. Biol. Chem.267, 17688–17692 (1992). CASPubMed Google Scholar
Sancar, A. & Rupp, W.D. A novel repair enzyme: UvrABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region. Cell33, 249–260 (1983). ArticleCAS Google Scholar
Verhoeven, E.E., van Kesteren, M., Moolenaar, G.F., Visse, R. & Goosen, N. Catalytic sites for 3′ and 5′ incision of Escherichia coli nucleotide excision repair are both located in UvrC. J. Biol. Chem.275, 5120–5123 (2000). ArticleCAS Google Scholar
Caron, P.R., Kushner, S.R. & Grossman, L. Involvement of helicase-II (UvrD gene product) and DNA Polymerase-I in excision mediated by the UvrABC protein complex. Proc. Natl. Acad. Sci. USA82, 4925–4929 (1985). ArticleCAS Google Scholar
Husain, I., Houten, B.V., Thomas, D.C., Abdel-Monem, M. & Sancar, A. Effect of DNA polymerase I and DNA helicase II on the turnover rate of UvrABC excision nuclease. Proc. Natl. Acad. Sci. USA82, 6774–6778 (1985). ArticleCAS Google Scholar
Machius, M., Henry, L., Palnitkar, M. & Deisenhofer, J. Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus. Proc. Natl. Acad. Sci. USA96, 11717–11722 (1999). ArticleCAS Google Scholar
Nakagawa, N. et al. Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair. J. Biochem.126, 986–990 (1999). ArticleCAS Google Scholar
Theis, K., Chen, P.J., Skorvaga, M., Houten, B.V. & Kisker, C. Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair. EMBO J.18, 6899–6907 (1999). ArticleCAS Google Scholar
Truglio, J.J. et al. Interactions between UvrA and UvrB: the role of UvrB's domain 2 in nucleotide excision repair. EMBO J.23, 2498–2509 (2004). ArticleCAS Google Scholar
Hsu, D.S., Kim, S.T., Sun, Q. & Sancar, A. Structure and function of the UvrB protein. J. Biol. Chem.270, 8319–8327 (1995). ArticleCAS Google Scholar
Gordienko, I. & Rupp, W.D. The limited strand-separating activity of the UvrAB protein complex and its role in the recognition of DNA damage. EMBO J.16, 889–895 (1997). ArticleCAS Google Scholar
Visse, R., King, A., Moolenaar, G.F., Goosen, N. & van de Putte, P. Protein-DNA interactions and alterations in the DNA structure upon UvrB-DNA preincision complex formation during nucleotide excision repair in Escherichia coli. Biochemistry33, 9881–9888 (1994). ArticleCAS Google Scholar
Zou, Y. & Van Houten, B. Strand opening by the UvrA2B complex allows dynamic recognition of DNA damage. EMBO J.18, 4889–4901 (1999). ArticleCAS Google Scholar
Skorvaga, M. et al. Identification of residues within UvrB that are important for efficient DNA binding and damage processing. J. Biol. Chem.279, 51574–51580 (2004). ArticleCAS Google Scholar
DellaVecchia, M.J. et al. Analyzing the handoff of DNA from UvrA to UvrB utilizing DNA-protein photoaffinity labeling. J. Biol. Chem.279, 45245–45256 (2004). ArticleCAS Google Scholar
Moolenaar, G.F., Hoglund, L. & Goosen, N. Clue to damage recognition by UvrB: residues in the beta-hairpin structure prevent binding to non-damaged DNA. EMBO J.20, 6140–6149 (2001). ArticleCAS Google Scholar
Moolenaar, G.F., Schut, M. & Goosen, N. Binding of the UvrB dimer to non-damaged and damaged DNA: residues Y92 and Y93 influence the stability of both subunits. DNA Repair (Amst.)4, 699–713 (2005). ArticleCAS Google Scholar
Zou, Y. et al. DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair. Biochemistry43, 4196–4205 (2004). ArticleCAS Google Scholar
Sancar, A., Franklin, K.A. & Sancar, G.B. Escherichia coli DNA photolyase stimulates uvrABC excision nuclease in vitro. Proc. Natl. Acad. Sci. USA81, 7397–7401 (1984). ArticleCAS Google Scholar
Mees, A. et al. Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair. Science306, 1789–1793 (2004). ArticleCAS Google Scholar
Malta, E., Moolenaar, G.F. & Goosen, N. Base flipping in nucleotide excision repair. J. Biol. Chem.281, 2184–2194 (2006). ArticleCAS Google Scholar
Zou, Y., Walker, R., Bassett, H., Geacintov, N.E. & Houten, B.V. Formation of DNA repair intermediates and incision by the ATP-dependent UvrB-UvrC endonuclease. J. Biol. Chem.272, 4820–4827 (1997). ArticleCAS Google Scholar
Moolenaar, G.F. et al. The effect of the DNA flanking the lesion on formation of the UvrB-DNA preincision complex. J. Biol. Chem.275, 8038–8043 (2000). ArticleCAS Google Scholar
Shi, Q., Thresher, R., Sancar, A. & Griffith, J. Electron microscopic study of (A)BC excinuclease—DNA is sharply bent in the UvrB-DNA complex. J. Mol. Biol.226, 425–432 (1992). ArticleCAS Google Scholar
Lin, J.J., Phillips, A.M., Hearst, J.E. & Sancar, A. Active site of (A)BC excinuclease: II. Binding, bending and catalysis mutants of UvrB reveal a direct role in 3′ and an indirect role in 5′ incision. J. Biol. Chem.267, 17693–17700 (1992). CASPubMed Google Scholar
Verhoeven, E.E., Wyman, C., Moolenaar, G.F., Hoeijmakers, J.H. & Goosen, N. Architecture of nucleotide excision repair complexes: DNA is wrapped by UvrB before and after damage recognition. EMBO J.20, 601–611 (2001). ArticleCAS Google Scholar
Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol.276, 307–326 (1997). ArticleCAS Google Scholar
Collaborative Computational Project, Number 4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr.50, 760–763 (1994).
Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A47, 110–119 (1991). Article Google Scholar
Laskowski, R.A., McArthur, M.W., Moss, D.S. & Thornton, J.M. PROCHECK—a program to check the stereochemical quality of protein structures. J. Appl. Crystallogr.26, 283–291 (1993). ArticleCAS Google Scholar