Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity (original) (raw)

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Acknowledgements

We thank T. Kasuya, Y. Kito, K. Senda and K. Hattori for their help in the preparation of recombinant proteins. Work in the laboratory of K.K. and Y.Y. was supported by a Grant-in-Aid for Scientific Research on Priority Areas (17028047 and 18076003) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by a Grant-in-Aid for Scientific Research (B) (18390016) from Japan Society for the Promotion of Science. E.S. is a recipient of Japan Society for the Promotion of Science Research Fellowships for Young Scientists.

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Authors and Affiliations

  1. Department of Structural Biology and Biomolecular Engineering, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, 467-8603, Nagoya, Japan
    Eri Sakata, Yoshiki Yamaguchi & Koichi Kato
  2. Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan
    Yasuhiro Miyauchi & Kazuhiro Iwai
  3. Department of Molecular Biology, Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577, Ibaraki, Japan
    Tomoki Chiba
  4. Laboratory of Frontier Science, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, 113-8613, Tokyo, Japan
    Yasushi Saeki, Noriyuki Matsuda & Keiji Tanaka
  5. Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, 444-8787, Okazaki, Aichi, Japan
    Koichi Kato

Authors

  1. Eri Sakata
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  2. Yoshiki Yamaguchi
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  3. Yasuhiro Miyauchi
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  4. Kazuhiro Iwai
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  5. Tomoki Chiba
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  6. Yasushi Saeki
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  7. Noriyuki Matsuda
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  8. Keiji Tanaka
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  9. Koichi Kato
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Contributions

K.K. contributed to overall guidance of the project. E.S., Y.Y. and K.K. contributed to the design and execution of the NMR study. E.S., K.I., T.C. and K.T. contributed to the design of the mutational studies. E.S., Y.M., Y.S. and N.M. contributed to the execution of the mutational studies. E.S. and K.K. wrote the manuscript. K.I., T.C. and K.T. commented on the manuscript. All authors edited and approved the final version of the manuscript.

Corresponding author

Correspondence toKoichi Kato.

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The authors declare no competing financial interests.

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Sakata, E., Yamaguchi, Y., Miyauchi, Y. et al. Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.Nat Struct Mol Biol 14, 167–168 (2007). https://doi.org/10.1038/nsmb1191

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