Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase (original) (raw)

Nature Structural & Molecular Biology volume 14, pages 243–245 (2007)Cite this article

An Erratum to this article was published on 01 April 2007

Abstract

Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5′ regions of transcribed genes. Here we identify a novel budding yeast JmjC domain–containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.

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Acknowledgements

We thank J. Lieb (University of North Carolina, Chapel Hill), H. Dolhman (University of North Carolina, Chapel Hill) and C. Brandl (University of Western Ontario) for providing plasmids, B. Strahl (University of North Carolina, Chapel Hill) for providing the BY4741, _set2_Δ, _spt4_Δ, _rtf1_Δ, _snf2_Δ, _spt7_Δ, _htz1_Δ and _sir2_Δ strains, and E. Turnbull for critical reading of the manuscript. This work was supported by US National Institutes of Health grant GM68804 (to Y.Z.). Y.Z. is an Investigator of the Howard Hughes Medical Institute. R.J.K. is supported by the Canadian Institutes of Health Research.

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Author notes

  1. Gaoyang Liang and Robert J Klose: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, 27599-7295, North Carolina, USA
    Gaoyang Liang, Robert J Klose, Kathryn E Gardner & Yi Zhang

Authors

  1. Gaoyang Liang
  2. Robert J Klose
  3. Kathryn E Gardner
  4. Yi Zhang

Contributions

G.L., R.J.K., K.E.G. and Y.Z. designed the experiments. G.L., R.J.K. and K.E.G. carried out the experiments. R.J.K. and Y.Z. wrote the manuscript.

Corresponding author

Correspondence toYi Zhang.

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The authors declare no competing financial interests.

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Liang, G., Klose, R., Gardner, K. et al. Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase.Nat Struct Mol Biol 14, 243–245 (2007). https://doi.org/10.1038/nsmb1204

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