Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast (original) (raw)
Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H et al. (2004). Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell6: 17–32. ArticleCAS Google Scholar
Briand P, Nielsen KV, Madsen MW, Petersen OW . (1996). Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal. Cancer Res56: 2039–2044. CAS Google Scholar
Campbell IG, Qiu W, Polyak K, Haviv I . (2008). Breast-cancer stromal cells with TP53 mutations. N Engl J Med358: 1634–1635; author reply 1636. ArticleCAS Google Scholar
Casey T, Bond J, Tighe S, Hunter T, Lintault L, Patel O et al. (2008). Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer. Breast Cancer Res Treat114: 47–62. Article Google Scholar
Chang CF, Westbrook R, Ma J, Cao D . (2007). Transforming growth factor-beta signaling in breast cancer. Front Biosci12: 4393–4401. ArticleCAS Google Scholar
de Jong JS, van Diest PJ, van der Valk P, Baak JP . (1998). Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: an inventory in search of autocrine and paracrine loops. J Pathol184: 44–52. ArticleCAS Google Scholar
Duque JL, Adam RM, Mullen JS, Lin J, Richie JP, Freeman MR . (2001). Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell growth in vitro. J Urol165: 284–288. ArticleCAS Google Scholar
Erickson AC, Barcellos-Hoff MH . (2003). The not-so innocent bystander: the microenvironment as a therapeutic target in cancer. Expert Opin Ther Targets7: 71–88. ArticleCAS Google Scholar
Farmer P, Bonnefoi H, Anderle P, Cameron D, Wirapati P, Becette V et al. (2009). A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat Med15: 68–74. ArticleCAS Google Scholar
Fiegl H, Millinger S, Goebel G, Muller-Holzner E, Marth C, Laird PW et al. (2006). Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res66: 29–33. ArticleCAS Google Scholar
Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, Zhao H et al. (2008). Stromal gene expression predicts clinical outcome in breast cancer. Nat Med14: 518–527. ArticleCAS Google Scholar
Hu M, Yao J, Cai L, Bachman KE, van den Brule F, Velculescu V et al. (2005). Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet37: 899–905. ArticleCAS Google Scholar
Iacobuzio-Donahue CA, Argani P, Hempen PM, Jones J, Kern SE . (2002). The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types. Cancer Res62: 5351–5357. CASPubMed Google Scholar
Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U et al. (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics4: 249–264. Article Google Scholar
Ji Q, Aoyama C, Nien YD, Liu PI, Chen PK, Chang L et al. (2004). Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling. Cancer Res64: 7610–7617. ArticleCAS Google Scholar
Kalluri R, Zeisberg M . (2006). Fibroblasts in cancer. Nat Rev Cancer6: 392–401. ArticleCAS Google Scholar
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW et al. (2007). Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature449: 557–563. ArticleCAS Google Scholar
Kendziorski CM, Newton MA, Lan H, Gould MN . (2003). On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles. Stat Med22: 3899–3914. ArticleCAS Google Scholar
Kim YC, Clark RJ, Ranheim EA, Alexander CM . (2008). Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous beta-catenin effector. Cancer Res68: 10145–10153. ArticleCAS Google Scholar
Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C . (2002). Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet32: 355–357. ArticleCAS Google Scholar
Lewis MJ, Wiebe JP, Heathcote JG . (2004). Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma. BMC Cancer4: 27. Article Google Scholar
Massague J . (2007). Sorting out breast-cancer gene signatures. N Engl J Med356: 294–297. ArticleCAS Google Scholar
Mercier I, Casimiro MC, Wang C, Rosenberg AL, Quong J, Minkeu A et al. (2008). Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: implications for the response to hormonal therapy. Cancer Biol Ther7: 1212–1225. ArticleCAS Google Scholar
Mishra PJ, Mishra PJ, Humeniuk R, Medina DJ, Alexe G, Mesirov JP et al. (2008). Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res68: 4331–4339. ArticleCAS Google Scholar
Mueller MM, Fusenig NE . (2004). Friends or foes— bipolar effects of the tumour stroma in cancer. Nat Rev Cancer4: 839–849. ArticleCAS Google Scholar
Nakagawa H, Liyanarachchi S, Davuluri RV, Auer H, Martin EW, De La Chapelle A et al. (2004). Role of cancer-associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles. Oncogene23: 7366–7377. ArticleCAS Google Scholar
Narita K, Chien J, Mullany SA, Staub J, Qian X, Lingle WL et al. (2007). Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer. J Biol Chem282: 14413–14420. ArticleCAS Google Scholar
Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R et al. (2005). Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell121: 335–348. ArticleCAS Google Scholar
Patocs A, Zhang L, Xu Y, Weber F, Caldes T, Mutter GL et al. (2007). Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med357: 2543–2551. ArticleCAS Google Scholar
Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J et al. (1998). WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci USA95: 14717–14722. ArticleCAS Google Scholar
Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA et al. (2000). Molecular portraits of human breast tumours. Nature406: 747–752. ArticleCAS Google Scholar
Qiu W, Hu M, Sridhar A, Opeskin K, Fox S, Shipitsin M et al. (2008). No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet40: 650–655. ArticleCAS Google Scholar
R-Development-Core-Team (2008). A language and environment for statistical computing. R Foundation for Statistical Computing. http://www.r-project.org.
Singer CF, Gschwantler-Kaulich D, Fink-Retter A, Haas C, Hudelist G, Czerwenka K et al. (2007). Differential gene expression profile in breast cancer-derived stromal fibroblasts. Breast Cancer Res Treat110: 273–281. Article Google Scholar
Singer CF, Gschwantler-Kaulich D, Fink-Retter A, Haas C, Hudelist G, Czerwenka K et al. (2008). Differential gene expression profile in breast cancer-derived stromal fibroblasts. Breast Cancer Res Treat110: 273–281. ArticleCAS Google Scholar
Singer CF, Kronsteiner N, Marton E, Kubista M, Cullen KJ, Hirtenlehner K et al. (2002). MMP-2 and MMP-9 expression in breast cancer-derived human fibroblasts is differentially regulated by stromal-epithelial interactions. Breast Cancer Res Treat72: 69–77. ArticleCAS Google Scholar
Storey JD, Tibshirani R . (2003). Statistical significance for genomewide studies. Proc Natl Acad Sci USA100: 9440–9445. ArticleCAS Google Scholar
Sutmuller M, Bruijn JA, de Heer E . (1997). Collagen types VIII and X, two non-fibrillar, short-chain collagens. Structure homologies, functions and involvement in pathology. Histol Histopathol12: 557–566. CASPubMed Google Scholar
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K et al. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell131: 861–872. ArticleCAS Google Scholar
Tang Y, Kesavan P, Nakada MT, Yan L . (2004). Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res2: 73–80. CASPubMed Google Scholar
van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M et al. (2002). Gene expression profiling predicts clinical outcome of breast cancer. Nature415: 530–536. ArticleCAS Google Scholar
Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP . (2001). Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res61: 8917–8923. CAS Google Scholar
You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan KL et al. (2002). Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol157: 429–440. ArticleCAS Google Scholar
Zhang W, Chen X, Kato Y, Evans PM, Yuan S, Yang J et al. (2006). Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol26: 2055–2064. ArticleCAS Google Scholar