MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells (original) (raw)

• Ahmed N, Thompson EW, Quinn MA . (2007). Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm. J Cell Physiol 213: 581–588.
  Article CAS PubMed Google Scholar
• Andrianifahanana M, Moniaux N, Schmied BM, Ringel J, Friess H, Hollingsworth MA et al. (2001). Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin Cancer Res 7: 4033–4040.
  CAS PubMed Google Scholar
• Auersperg N, Pan J, Grove BD, Peterson T, Fisher J, Maines-Bandiera S et al. (1999). E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium. Proc Natl Acad Sci USA 96: 6249–6254.
  Article CAS PubMed PubMed Central Google Scholar
• Behrens J . (1994). Cadherins as determinants of tissue morphology and suppressors of invasion. Acta Anat (Basel) 149: 165–169.
  Article CAS Google Scholar
• Boman F, Buisine MP, Wacrenier A, Querleu D, Aubert JP, Porchet N . (2001). Mucin gene transcripts in benign and borderline mucinous tumours of the ovary: an in situ hybridization study. J Pathol 193: 339–344.
  Article CAS PubMed Google Scholar
• Carraway KL, Price-Schiavi SA, Komatsu M, Jepson S, Perez A, Carraway CA . (2001). Muc4/sialomucin complex in the mammary gland and breast cancer. J Mammary Gland Biol Neoplasia 6: 323–337.
  Article CAS PubMed Google Scholar
• Chaturvedi P, Singh AP, Moniaux N, Senapati S, Chakraborty S, Meza JL et al. (2007). MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol Cancer Res 5: 309–320.
  Article CAS PubMed Google Scholar
• Chauhan SC, Singh AP, Ruiz F, Johansson SL, Jain M, Smith LM et al. (2006). Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125). Mod Pathol 19: 1386–1394.
  Article CAS PubMed Google Scholar
• Chen H, Paradies NE, Fedor-Chaiken M, Brackenbury R . (1997). E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms. J Cell Sci 110: 345–356.
  CAS PubMed Google Scholar
• Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, Byers HR et al. (1992). Actin-binding protein requirement for cortical stability and efficient locomotion. Science 255: 325–327.
  Article CAS PubMed Google Scholar
• Fidler IJ . (1990). Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res 50: 6130–6138.
  CAS PubMed Google Scholar
• Folkman J . (1990). Endothelial cells and angiogenic growth factors in cancer growth and metastasis. Introduction. Cancer Metastasis Rev 9: 171–174.
  Article CAS PubMed Google Scholar
• Giuntoli RL, Rodriguez GC, Whitaker RS, Dodge R, Voynow JA . (1998). Mucin gene expression in ovarian cancers. Cancer Res 58: 5546–5550.
  CAS PubMed Google Scholar
• Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D et al. (2008). A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem 51: 7405–7416.
  Article CAS PubMed PubMed Central Google Scholar
• Gravdal K, Halvorsen OJ, Haukaas SA, Akslen LA . (2007). A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res 13: 7003–7011.
  Article CAS PubMed Google Scholar
• Hazan RB, Kang L, Whooley BP, Borgen PI . (1997). N-cadherin promotes adhesion between invasive breast cancer cells and the stroma. Cell Adhes Commun 4: 399–411.
  Article CAS PubMed Google Scholar
• Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA . (2000). Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol 148: 779–790.
  Article CAS PubMed PubMed Central Google Scholar
• Hazan RB, Qiao R, Keren R, Badano I, Suyama K . (2004). Cadherin switch in tumor progression. Ann NY Acad Sci 1014: 155–163.
  Article CAS PubMed Google Scholar
• Hollingsworth MA, Swanson BJ . (2004). Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 4: 45–60.
  Article CAS PubMed Google Scholar
• Horn G, Gaziel A, Wreschner DH, Smorodinsky NI, Ehrlich M . (2009). ERK and PI3K regulate different aspects of the epithelial to mesenchymal transition of mammary tumor cells induced by truncated MUC1. Exp Cell Res 315: 1490–1504.
  Article CAS PubMed Google Scholar
• Kang Y, Massague J . (2004). Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118: 277–279.
  Article CAS PubMed Google Scholar
• Kolosionek E, Savai R, Ghofrani HA, Weissmann N, Guenther A, Grimminger F et al. (2009). Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. Mol Biol Cell 20: 4751–4765.
  Article CAS PubMed PubMed Central Google Scholar
• Kondo K, Kohno N, Yokoyama A, Hiwada K . (1998). Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines. Cancer Res 58: 2014–2019.
  CAS PubMed Google Scholar
• Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y . (2009). Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15: 195–206.
  Article CAS PubMed Google Scholar
• Lopez-Ferrer A, Alameda F, Barranco C, Garrido M, de Bolós C . (2001). MUC4 expression is increased in dysplastic cervical disorders. Hum Pathol 32: 1197–1202.
  Article CAS PubMed Google Scholar
• Maeda M, Johnson KR, Wheelock MJ . (2005). Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. J Cell Sci 118: 873–887.
  Article CAS PubMed Google Scholar
• Moniaux N, Chaturvedi P, Varshney GC, Meza JL, Rodriguez-Sierra JF, Aubert JP et al. (2007). Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells. Br J Cancer 97: 345–357.
  Article CAS PubMed PubMed Central Google Scholar
• Moniaux N, Nollet S, Porchet N, Degand P, Laine A, Aubert JP . (1999). Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. Biochem J 338: 325–333.
  Article CAS PubMed PubMed Central Google Scholar
• Moniaux N, Varshney GC, Chauhan SC, Copin MC, Jain M, Wittel UA et al. (2004). Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. J Histochem Cytochem 52: 253–261.
  Article CAS PubMed Google Scholar
• Nollet S, Moniaux N, Maury J, Petitprez D, Degand P, Laine A et al. (1998). Human mucin gene MUC4: organization of its 5′-region and polymorphism of its central tandem repeat array. Biochem J 332: 739–748.
  Article CAS PubMed PubMed Central Google Scholar
• Ponnusamy MP, Singh AP, Jain M, Chakraborty S, Moniaux N, Batra SK . (2008). MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells. Br J Cancer 99: 520–526.
  Article CAS PubMed PubMed Central Google Scholar
• Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR . (2008). Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol 180: 1277–1289.
  Article CAS PubMed PubMed Central Google Scholar
• Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK . (2004). Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res 64: 622–630.
  Article CAS PubMed Google Scholar
• Sommers CL . (1996). The role of cadherin-mediated adhesion in breast cancer. J Mammary Gland Biol Neoplasia 1: 219–229.
  Article CAS PubMed Google Scholar
• Suyama K, Shapiro I, Guttman M, Hazan RB . (2002). A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell 2: 301–314.
  Article CAS PubMed Google Scholar
• Theriault BL, Shepherd TG, Mujoomdar ML, Nachtigal MW . (2007). BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells. Carcinogenesis 28: 1153–1162.
  Article CAS PubMed Google Scholar
• Thiery JP . (2002). Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442–454.
  Article CAS PubMed Google Scholar
• Truant S, Bruyneel E, Gouyer V, De WO, Pruvot FR, Mareel M et al. (2003). Requirement of both mucins and proteoglycans in cell-cell dissociation and invasiveness of colon carcinoma HT-29 cells. Int J Cancer 104: 683–694.
  Article CAS PubMed Google Scholar