Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion (original) (raw)

• Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED et al. (2009). The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J 28: 3623–3632.
  Article CAS Google Scholar
• Bazzoni G, Shih DT, Buck CA, Hemler ME . (1995). Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem 270: 25570–25577.
  Article CAS Google Scholar
• Bouaouina M, Lad Y, Calderwood DA . (2008). The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins. J Biol Chem 283: 6118–6125.
  Article CAS Google Scholar
• Bouvard D, Vignoud L, Dupé-Manet S, Abed N, Fournier HN, Vincent-Monegat C et al. (2003). Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha. J Biol Chem 278: 6567–6574.
  Article CAS Google Scholar
• Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P et al. (2009). SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol 11: 557–568.
  Article CAS Google Scholar
• Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ . (2009). Anti-integrin monoclonal antibodies. J Cell Sci 122: 4009–4011.
  Article CAS Google Scholar
• Böttcher RT, Lange A, Fässler R . (2009). How ILK and kindlins cooperate to orchestrate integrin signaling. Curr Opin Cell Biol 21: 670–675.
  Article Google Scholar
• Clark AJ, Neil C, Gusterson B, McWhir J, Binas B . (2000). Deletion of the gene encoding H-FABP/MDGI has no overt effects in the mammary gland. Transgenic Res 9: 439–444.
  Article CAS Google Scholar
• Czuchra A, Meyer H, Legate KR, Brakebusch C, Fässler R . (2006). Genetic analysis of beta1 integrin ″activation motifs″ in mice. J Cell Biol 174: 889–899.
  Article CAS Google Scholar
• Gietz RD, Woods RA . (2002). Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. Methods Enzymol 350: 87–96.
  Article CAS Google Scholar
• Harburger DS, Bouaouina M, Calderwood DA . (2009). Kindlin-1 and −2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem 284: 11485–11497.
  Article CAS Google Scholar
• Hertzel AV, Bernlohr DA . (2000). The mammalian fatty acid-binding protein multigene family: molecular and genetic insights into function. Trends Endocrinol Metab 11: 175–180.
  Article CAS Google Scholar
• Huttenlocher A, Sandborg RR, Horwitz AF . (1995). Adhesion in cell migration. Curr Opin Cell Biol 7: 697–706.
  Article CAS Google Scholar
• Huynh H, Alpert L, Pollak M . (1996). Silencing of the mammary-derived growth inhibitor (MDGI) gene in breast neoplasms is associated with epigenetic changes. Cancer Res 56: 4865–4870.
  CAS PubMed Google Scholar
• Huynh H, Pollak M . (1997). Stabilization of mammary-derived growth inhibitor messenger RNA by antiestrogens. Clin Cancer Res 3: 2151–2156.
  CAS PubMed Google Scholar
• Hynes RO . (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110: 673–687.
  Article CAS Google Scholar
• Jarvius M, Paulsson J, Weibrecht I, Leuchowius KJ, Andersson AC, Wählby C et al. (2007). In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method. Mol Cell Proteomics 6: 1500–1509.
  Article CAS Google Scholar
• Kiosses WB, Shattil SJ, Pampori N, Schwartz MA . (2001). Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol 3: 316–320.
  Article CAS Google Scholar
• Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC . (2004). The kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem 279: 6824–6833.
  Article CAS Google Scholar
• Koistinen P, Pulli T, Uitto VJ, Nissinen L, Hyypi T, Heino J . (1999). Depletion of alphaV integrins from osteosarcoma cells by intracellular antibody expression induces bone differentiation marker genes and suppresses gelatinase (MMP-2) synthesis. Matrix Biol 18: 239–251.
  Article CAS Google Scholar
• Kurtz A, Vogel F, Funa K, Heldin CH, Grosse R . (1990). Developmental regulation of mammary-derived growth inhibitor expression in bovine mammary tissue. J Cell Biol 110: 1779–1789.
  Article CAS Google Scholar
• Lau TL, Kim C, Ginsberg MH, Ulmer TS . (2009). The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J 28: 1351–1361.
  Article CAS Google Scholar
• Legate KR, Wickström SA, Fässler R . (2009). Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 23: 397–418.
  Article CAS Google Scholar
• Lehtonen JV, Still DJ, Rantanen VV, Ekholm J, Björklund D, Iftikhar Z et al. (2004). BODIL: a molecular modeling environment for structure-function analysis and drug design. J Comput Aided Mol Des 18: 401–419.
  Article CAS Google Scholar
• Lundin J, Lundin M, Holli K, Kataja V, Elomaa L, Pylkkänen L et al. (2001). Omission of histologic grading from clinical decision making may result in overuse of adjuvant therapies in breast cancer: results from a nationwide study. J Clin Oncol 19: 28–36.
  Article CAS Google Scholar
• Luo BH, Springer TA, Takagi J . (2004). A specific interface between integrin transmembrane helices and affinity for ligand. PLoS Biol 2: e153.
  Article Google Scholar
• Luque A, Gomez M, Puzon W, Takada Y, Sanchez-Madrid F, Cabanas C . (1996). Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain. J Biol Chem 271: 11067–11075.
  Article CAS Google Scholar
• Lücke C, Rademacher M, Zimmerman AW, van Moerkerk HT, Veerkamp JH, Rüterjans H . (2001). Spin-system heterogeneities indicate a selected-fit mechanism in fatty acid binding to heart-type fatty acid-binding protein (H-FABP). Biochem J 354: 259–266.
  Article Google Scholar
• Mattila E, Pellinen T, Nevo J, Vuoriluoto K, Arjonen A, Ivaska J . (2005). Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP. Nat Cell Biol 7: 78–85.
  Article CAS Google Scholar
• Millon-Frémillon A, Bouvard D, Grichine A, Manet-Dupé S, Block MR, Albiges-Rizo C . (2008). Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity. J Cell Biol 180: 427–441.
  Article Google Scholar
• Nevo J, Mattila E, Pellinen T, Yamamoto DL, Sara H, Iljin K et al. (2009). Mammary-derived growth inhibitor alters traffic of EGFR and induces a novel form of cetuximab resistance. Clin Cancer Res 15: 6570–6581.
  Article CAS Google Scholar
• Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J . (2006). Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J Cell Biol 173: 767–780.
  Article CAS Google Scholar
• Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ . (1992). Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci USA 89: 9064–9068.
  Article CAS Google Scholar
• Shi X, Ma YQ, Tu Y, Chen K, Wu S, Fukuda K et al. (2007). The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility. J Biol Chem 282: 20455–20466.
  Article CAS Google Scholar
• Söderberg O, Gullberg M, Jarvius M, Ridderstrale K, Leuchowius KJ, Jarvius J et al. (2006). Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 3: 995–1000.
  Article Google Scholar
• Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM et al. (2003). Talin binding to integrin beta tails: a final common step in integrin activation. Science 302: 103–106.
  Article CAS Google Scholar
• Takala H, Nurminen E, Nurmi SM, Aatonen M, Strandin T, Takatalo M et al. (2008). Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding. Blood 112: 1853–1862.
  Article CAS Google Scholar
• Tuomi S, Mai A, Nevo J, Laine JO, Vilkki V, hman TJ et al. (2009). PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. Sci Signal 2: ra32.
  Article Google Scholar
• Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW et al. (2002). Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst 94: 1494–1503.
  Article CAS Google Scholar
• Wang HL, Kurtz A . (2000). Breast cancer growth inhibition by delivery of the MDGI-derived peptide P108. Oncogene 19: 2455–2460.
  Article CAS Google Scholar
• Wang W, Goswami S, Lapidus K, Wells AL, Wyckoff JB, Sahai E et al. (2004). Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res 64: 8585–8594.
  Article CAS Google Scholar
• Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C et al. (1997). Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137: 231–245.
  Article CAS Google Scholar
• Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH et al. (2007). Structural basis of integrin activation by talin. Cell 128: 171–182.
  Article CAS Google Scholar
• White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U et al. (2004). Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 6: 159–170.
  Article CAS Google Scholar
• Vinogradova O, Vaynberg J, Kong X, Haas TA, Plow EF, Qin J . (2004). Membrane-mediated structural transitions at the cytoplasmic face during integrin activation. Proc Natl Acad Sci USA 101: 4094–4099.
  Article CAS Google Scholar
• Yao ES, Zhang H, Chen YY, Lee B, Chew K, Moore D et al. (2007). Increased beta1 integrin is associated with decreased survival in invasive breast cancer. Cancer Res 67: 659–664.
  Article CAS Google Scholar
• Zhang X, Jiang G, Cai Y, Monkley SJ, Critchley DR, Sheetz MP . (2008). Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol 10: 1062–1068.
  Article CAS Google Scholar