Adachi Y, Aoki C, Yoshio-Hoshino N, Takayama K, Curiel DT, Nishimoto N . (2006). Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas. Int J Cancer119: 1303–1311. ArticleCAS Google Scholar
Ahmed N, Riley C, Oliva K, Stutt E, Rice GE, Quinn MA . (2003). Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid. J Pathol201: 229–237. ArticleCAS Google Scholar
Bravou V, Klironomos G, Papadaki E, Stefanou D, Varakis J . (2003). Integrin-linked kinase (ILK) expression in human colon cancer. Br J Cancer89: 2340–2341. ArticleCAS Google Scholar
Chen LF, Greene WC . (2004). Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol5: 392–401. ArticleCAS Google Scholar
Cohen T, Nahari D, Cerem LW, Neufeld G, Levi BZ . (1996). Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem271: 736–741. ArticleCAS Google Scholar
Czubayko F, Schulte AM, Berchem GJ, Wellstein A . (1996). Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin. Proc Natl Acad Sci USA93: 14753–14758. ArticleCAS Google Scholar
Dai DL, Makretsov N, Campos EI, Huang C, Zhou Y, Huntsman D et al. (2003). Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin Cancer Res9: 4409–4414. CASPubMed Google Scholar
D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B et al. (2000). The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. J Biol Chem275: 32649–32657. ArticleCAS Google Scholar
Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S . (1998). Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA95: 11211–11216. ArticleCAS Google Scholar
Delrieu I, Faye JC, Bayard F, Maret A . (1999). Inhibition of interleukin-6 promoter activity by the 24 kDa isoform of fibroblast growth factor-2 in HeLa cells. Biochem J340 (Part 1): 201–206. ArticleCAS Google Scholar
Gao K, Dai DL, Martinka M, Li G . (2006). Prognostic significance of nuclear factor-kappaB p105/p50 in human melanoma and its role in cell migration. Cancer Res66: 8382–8388. ArticleCAS Google Scholar
Graff JR, Deddens JA, Konicek BW, Colligan BM, Hurst BM, Carter HW et al. (2001). Integrin-linked kinase expression increases with prostate tumor grade. Clin Cancer Res7: 1987–1991. CASPubMed Google Scholar
Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J et al. (1996). Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature379: 91–96. ArticleCAS Google Scholar
Hershko DD, Robb BW, Luo G, Hasselgren PO . (2002). Multiple transcription factors regulating the IL-6 gene are activated by cAMP in cultured Caco-2 cells. Am J Physiol Regul Integr Comp Physiol283: R1140–R1148. Article Google Scholar
Hoek K, Rimm DL, Williams KR, Zhao H, Ariyan S, Lin A et al. (2004). Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res64: 5270–5282. ArticleCAS Google Scholar
Huang SP, Wu MS, Shun CT, Wang HP, Lin MT, Kuo ML et al. (2004). Interleukin-6 increases vascular endothelial growth factor and angiogenesis in gastric carcinoma. J Biomed Sci11: 517–527. ArticleCAS Google Scholar
Ito R, Oue N, Zhu X, Yoshida K, Nakayama H, Yokozaki H et al. (2003). Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma. Virchows Arch442: 118–123. CASPubMed Google Scholar
Jee SH, Chu CY, Chiu HC, Huang YL, Tsai WL, Liao YH et al. (2004). Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt pathways. J Invest Dermatol123: 1169–1175. ArticleCAS Google Scholar
Jerant AF, Johnson JT, Sheridan CD, Caffrey TJ . (2000). Early detection and treatment of skin cancer. Am Fam Physician62: 357–368, 375-356, 381-352. CASPubMed Google Scholar
Karst AM, Gao K, Nelson CC, Li G . (2009). Nuclear factor kappa B subunit p50 promotes melanoma angiogenesis by upregulating interleukin-6 expression. Int J Cancer124: 494–501. ArticleCAS Google Scholar
Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ et al. (2005). Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma. Mol Cancer Ther4: 1681–1688. ArticleCAS Google Scholar
Lazar-Molnar E, Hegyesi H, Toth S, Falus A . (2000). Autocrine and paracrine regulation by cytokines and growth factors in melanoma. Cytokine12: 547–554. ArticleCAS Google Scholar
Libermann TA, Baltimore D . (1990). Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol10: 2327–2334. ArticleCAS Google Scholar
Loeffler S, Fayard B, Weis J, Weissenberger J . (2005). Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int J Cancer115: 202–213. ArticleCAS Google Scholar
Lynch DK, Ellis CA, Edwards PA, Hiles ID . (1999). Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene18: 8024–8032. ArticleCAS Google Scholar
Maeshima Y, Colorado PC, Torre A, Holthaus KA, Grunkemeyer JA, Ericksen MB et al. (2000). Distinct antitumor properties of a type IV collagen domain derived from basement membrane. J Biol Chem275: 21340–21348. ArticleCAS Google Scholar
Mahnke JL, Dawood MY, Huang JC . (2000). Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis. Fertil Steril73: 166–170. ArticleCAS Google Scholar
Matsui H, Ihara Y, Fujio Y, Kunisada K, Akira S, Kishimoto T et al. (1999). Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes. Cardiovasc Res42: 104–112. ArticleCAS Google Scholar
Mouawad R, Rixe O, Meric JB, Khayat D, Soubrane C . (2002). Serum interleukin-6 concentrations as predictive factor of time to progression in metastatic malignant melanoma patients treated by biochemotherapy: a retrospective study. Cytokines Cell Mol Ther7: 151–156. ArticleCAS Google Scholar
Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J et al. (2002). Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene21: 2000–2008. ArticleCAS Google Scholar
Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J et al. (2000). Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA97: 3207–3212. ArticleCAS Google Scholar
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D et al. (2001). Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem276: 27462–27469. ArticleCAS Google Scholar
Persad S, Dedhar S . (2003). The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Rev22: 375–384. ArticleCAS Google Scholar
Ries LA, Wingo PA, Miller DS, Howe HL, Weir HK, Rosenberg HM et al. (2000). The annual report to the nation on the status of cancer, 1973–1997, with a special section on colorectal cancer. Cancer88: 2398–2424. ArticleCAS Google Scholar
Saidi A, Hagedorn M, Allain N, Verpelli C, Sala C, Bello L et al. (2009). Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness. Int J Cancer125: 1054–1064. ArticleCAS Google Scholar
Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W . (1999). IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem274: 30353–30356. ArticleCAS Google Scholar
Soengas MS, Lowe SW . (2003). Apoptosis and melanoma chemoresistance. Oncogene22: 3138–3151. ArticleCAS Google Scholar
Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K et al. (2004). Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell5: 79–90. ArticleCAS Google Scholar
Tan C, Mui A, Dedhar S . (2002). Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner. J Biol Chem277: 3109–3116. ArticleCAS Google Scholar
Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S . (2003). Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem278: 22374–22378. ArticleCAS Google Scholar
Troussard AA, Tan C, Yoganathan TN, Dedhar S . (1999). Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner. Mol Cell Biol19: 7420–7427. ArticleCAS Google Scholar
Watanabe M, Fujioka-Kaneko Y, Kobayashi H, Kiniwa M, Kuwano M, Basaki Y . (2005). Involvement of integrin-linked kinase in capillary/tube-like network formation of human vascular endothelial cells. Biol Proced Online7: 41–47. ArticleCAS Google Scholar
Wei LH, Kuo ML, Chen CA, Chou CH, Lai KB, Lee CN et al. (2003). Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene22: 1517–1527. ArticleCAS Google Scholar
Wong RP, Ng P, Dedhar S, Li G . (2007). The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth. Mol Cancer Ther6: 1692–1700. ArticleCAS Google Scholar
Wu C, Dedhar S . (2001). Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J Cell Biol155: 505–510. ArticleCAS Google Scholar
Xiao W, Hodge DR, Wang L, Yang X, Zhang X, Farrar WL . (2004). Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells. Prostate61: 354–370. ArticleCAS Google Scholar