The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma (original) (raw)

• Altschuler DL, Ribeiro-Neto F . (1998). Mitogenic and oncogenic properties of the small G protein Rap1b. Proc Natl Acad Sci USA 95: 7475–7479.
  Article CAS Google Scholar
• Beke L, Nuytten M, Van Eynde A, Beullens M, Bollen M . (2007). The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the polycomb group protein EZH2. Oncogene 26: 4590–4595.
  Article CAS Google Scholar
• Bos JL, de Rooij J, Reedquist KA . (2001). Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol 2: 369–377.
  Article CAS Google Scholar
• Bracken AP, Helin K . (2009). Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev Cancer 9: 773–784.
  Article CAS Google Scholar
• Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, Tomlins SA et al. (2008). Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 27: 7274–7284.
  Article CAS Google Scholar
• Caron E, Self AJ, Hall A . (2000). The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators [In Process Citation]. Curr Biol 10: 974–978.
  Article CAS Google Scholar
• Chi P, Allis CD, Wang GG . (2010). Covalent histone modifications—miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer 10: 457–469.
  Article CAS Google Scholar
• Chin D, Boyle GM, Porceddu S, Theile DR, Parsons PG, Coman WB . (2006). Head and neck cancer: past, present and future. Expert Rev Anticancer Ther 6: 1111–1118.
  Article Google Scholar
• Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV et al. (2010). Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 42: 722–726.
  Article CAS Google Scholar
• Francis NJ, Kingston RE, Woodcock CL . (2004). Chromatin compaction by a polycomb group protein complex. Science 306: 1574–1577.
  Article CAS Google Scholar
• Friedman JM, Liang G, Liu CC, Wolff EM, Tsai YC, Ye W et al. (2009). The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Res 69: 2623–2629.
  Article CAS Google Scholar
• Glazer CA, Chang SS, Ha PK, Califano JA . (2009). Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice. Oral Oncol 45: 440–446.
  Article CAS Google Scholar
• He LR, Liu MZ, Li BK, Jia WH, Zhang Y, Liao YJ et al. (2010). High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Int J Cancer 127: 138–147.
  Article CAS Google Scholar
• Herceg Z . (2007). Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors. Mutagenesis 22: 91–103.
  Article CAS Google Scholar
• Hogan C, Serpente N, Cogram P, Hosking CR, Bialucha CU, Feller SM et al. (2004). Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol Cell Biol 24: 6690–6700.
  Article CAS Google Scholar
• Kidani K, Osaki M, Tamura T, Yamaga K, Shomori K, Ryoke K et al. (2009). High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas. Oral Oncol 45: 39–46.
  Article CAS Google Scholar
• Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA et al. (2003). EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 100: 11606–11611.
  Article CAS Google Scholar
• Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, Charo C et al. (2008). Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet 40: 741–750.
  Article CAS Google Scholar
• Martinez-Garcia E, Licht JD . (2010). Deregulation of H3K27 methylation in cancer. Nat Genet 42: 100–101.
  Article CAS Google Scholar
• Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T et al. (2010). An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med 16: 286–294.
  Article CAS Google Scholar
• Mitra RS, Goto M, Lee JS, Maldonado D, Taylor JM, Pan Q et al. (2008). Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma. Cancer Res 68: 3959–3969.
  Article CAS Google Scholar
• Mitra RS, Zhang Z, Henson BS, Kurnit DM, Carey TE, D'Silva NJ . (2003). Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form. Oncogene 22: 6243–6256.
  Article CAS Google Scholar
• Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R et al. (2010). Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 42: 181–185.
  Article CAS Google Scholar
• Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M, Tonnissen ER et al. (2010). Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 42: 665–667.
  Article CAS Google Scholar
• Price LS, Hajdo-Milasinovic A, Zhao J, Zwartkruis FJ, Collard JG, Bos JL . (2004). Rap1 regulates E-cadherin-mediated cell-cell adhesion. J Biol Chem 279: 35127–35132.
  Article CAS Google Scholar
• Reedquist KA, Ross E, Koop EA, Wolthuis RM, Zwartkruis FJ, van Kooyk Y et al. (2000). The small GTPase, Rap1, mediates CD31-induced integrin adhesion. J Cell Biol 148: 1151–1158.
  Article CAS Google Scholar
• Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ et al. (1991). Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell 65: 1033–1042.
  Article CAS Google Scholar
• Simon JA, Lange CA . (2008). Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res 647: 21–29.
  Article CAS Google Scholar
• Stork PJ, Dillon TJ . (2005). Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood 106: 2952–2961.
  Article CAS Google Scholar
• Su L, Hattori M, Moriyama M, Murata N, Harazaki M, Kaibuchi K et al. (2003). AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem 278: 15232–15238.
  Article CAS Google Scholar
• Takai Y, Sasaki T, Matozaki T . (2001). Small GTP-binding proteins. Physiol Rev 81: 153–208.
  Article CAS Google Scholar
• Thomas GJ, Speight PM . (2001). Cell adhesion molecules and oral cancer. Crit Rev Oral Biol Med 12: 479–498.
  Article CAS Google Scholar
• Todd R, Donoff RB, Wong DT . (1997). The molecular biology of oral carcinogenesis: toward a tumor progression model. J Oral Maxillofac Surg 55: 613–623; discussion 623–615.
  Article CAS Google Scholar
• Tsygankova OM, Ma C, Tang W, Korch C, Feldman MD, Lv Y et al. (2010). Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Mol Cell Biol 30: 3262–3274.
  Article CAS Google Scholar
• Tsygankova OM, Prendergast GV, Puttaswamy K, Wang Y, Feldman MD, Wang H et al. (2007). Downregulation of Rap1GAP contributes to Ras transformation. Mol Cell Biol 27: 6647–6658.
  Article CAS Google Scholar
• Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B et al. (2008). Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322: 1695–1699.
  Article CAS Google Scholar
• Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG et al. (2002). The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419: 624–629.
  Article CAS Google Scholar
• Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C et al. (2006). The polycomb group protein EZH2 directly controls DNA methylation. Nature 439: 871–874.
  Article CAS Google Scholar
• Yang Y, Li X, Yang Q, Wang X, Zhou Y, Jiang T et al. (2010). The role of microRNA in human lung squamous cell carcinoma. Cancer Genet Cytogenet 200: 127–133.
  Article CAS Google Scholar
• Yarbrough WG, Slebos RJ, Liebler D . (2006). Proteomics: clinical applications for head and neck squamous cell carcinoma. Head Neck 28: 549–558.
  Article Google Scholar
• Yu J, Cao Q, Mehra R, Laxman B, Tomlins SA, Creighton CJ et al. (2007). Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell 12: 419–431.
  Article CAS Google Scholar
• Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X et al. (2010). An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 17: 443–454.
  Article CAS Google Scholar
• Zhang L, Chenwei L, Mahmood R, van Golen K, Greenson J, Li G et al. (2006a). Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer. Cancer Res 66: 898–906.
  Article CAS Google Scholar
• Zhang Z, Mitra RS, Henson BS, Datta NS, McCauley LK, Kumar P et al. (2006b). Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. Am J Pathol 168: 585–596.
  Article CAS Google Scholar
• Zheng H, Gao L, Feng Y, Yuan L, Zhao H, Cornelius LA . (2009). Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Cancer Res 69: 449–457.
  Article CAS Google Scholar
• Zuo H, Gandhi M, Edreira MM, Hochbaum D, Nimgaonkar VL, Zhang P et al. (2010). Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors. Cancer Res 70: 1389–1397.
  Article CAS Google Scholar