- Arnaoutova I, Kleinman HK . (2010). In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract. Nat Protoc 5: 628–635.
Article CAS Google Scholar
- Babic AM, Kireeva ML, Kolesnikova TV, Lau LF . (1998). CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc Natl Acad Sci USA 95: 6355–6360.
Article CAS Google Scholar
- Bailey JM, Mohr AM, Hollingsworth MA . (2009). Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 28: 3513–3525.
Article CAS Google Scholar
- Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C . (2010). Interactions between hedgehog proteins and their binding partners come into view. Genes Dev 24: 2001–2012.
Article CAS Google Scholar
- Bicknell R, Harris AL . (2004). Novel angiogenic signaling pathways and vascular targets. Annu Rev Pharmacol Toxicol 44: 219–238.
Article CAS Google Scholar
- Blagosklonny MV . (2004). Antiangiogenic therapy and tumor progression. Cancer Cell 5: 13–17.
Article CAS Google Scholar
- Byrd N, Grabel L . (2004). Hedgehog signaling in murine vasculogenesis and angiogenesis. Trends Cardiovasc Med 14: 308–313.
Article CAS Google Scholar
- Cao X, Geradts J, Dewhirst MW, Lo H-W . (2011). Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. Oncogene, (e-pub ahead of print 13 June 2011; doi:10.1038/onc.2011.219).
- Chen C-C, Lau LF . (2009). Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 41: 771–783.
Article CAS Google Scholar
- Chen CC, Mo FE, Lau LF . (2001). The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J Biol Chem 276: 47329–47337.
Article CAS Google Scholar
- Chinchilla P, Xiao L, Kazanietz MG, Riobo NA . (2010). Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle 9: 570–579.
Article CAS Google Scholar
- Cohen Jr MM . (2010). Hedgehog signaling update. Am J Med Genet A 152A: 1875–1914.
Article CAS Google Scholar
- Das S, Harris LG, Metge BJ, Liu S, Riker AI, Samant RS et al. (2009). The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin. J Biol Chem 284: 22888–22897.
Article CAS Google Scholar
- Das S, Samant RS, Shevde LA . (2011). Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis. J Biol Chem 286: 9612–9622.
Article CAS Google Scholar
- Dobroff AS, Wang H, Melnikova VO, Villares GJ, Zigler M, Huang L et al. (2009). Silencing cAMP-response element-binding protein (CREB) identifies CYR61 as a tumor suppressor gene in melanoma. J Biol Chem 284: 26194–26206.
Article CAS Google Scholar
- Feng P, Wang B, Ren EC . (2008). Cyr61/CCN1 is a tumor suppressor in human hepatocellular carcinoma and involved in DNA damage response. Int J Biochem Cell Biol 40: 98–109.
Article CAS Google Scholar
- Fox SB, Generali DG, Harris AL . (2007). Breast tumour angiogenesis. Breast Cancer Res 9: 216.
Article Google Scholar
- Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M et al. (2011). mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71: 3246–3256.
Article CAS Google Scholar
- Hochman E, Castiel A, Jacob-Hirsch J, Amariglio N, Izraeli S . (2006). Molecular pathways regulating pro-migratory effects of hedgehog signaling. J Biol Chem 281: 33860–33870.
Article CAS Google Scholar
- Kanda S, Mochizuki Y, Suematsu T, Miyata Y, Nomata K, Kanetake H . (2003). Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. J Biol Chem 278: 8244–8249.
Article CAS Google Scholar
- Kleer CG, Zhang Y, Merajver SD . (2007). CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancer. Cells Tissues Organs 185: 95–99.
Article CAS Google Scholar
- Lai D, Ho KC, Hao Y, Yang X . (2011). Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res 71: 2728–2738.
Article CAS Google Scholar
- Leu SJ, Lam SC, Lau LF . (2002). Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J Biol Chem 277: 46248–46255.
Article CAS Google Scholar
- Lin MT, Zuon CY, Chang CC, Chen ST, Chen CP, Lin BR et al. (2005). Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway. Clin Cancer Res 11: 5809–5820.
Article CAS Google Scholar
- Lu ZH, Jia J, Ren J, Ma B, Di LJ, Song GH . (2008). [Detection of breast cancer stem cells and the expression of key molecules in hedgehog signaling pathway]. Beijing Da Xue Xue Bao 40: 480–485.
CAS PubMed Google Scholar
- Mancuso MR, Davis R, Norberg SM, O'Brien S, Sennino B, Nakahara T et al. (2006). Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 116: 2610–2621.
Article CAS Google Scholar
- Mazumdar T, Devecchio J, Agyeman A, Shi T, Houghton JA . (2011). The GLI genes as the molecular switch in disrupting hedgehog signaling in colon cancer. Oncotarget 2: 638–645.
Article Google Scholar
- Mbeunkui F, Metge BJ, Shevde LA, Pannell LK . (2007). Identification of differentially secreted biomarkers using LC-MS/MS in isogenic cell lines representing a progression of breast cancer. J Proteome Res 6: 2993–3002.
Article CAS Google Scholar
- Merchant AA, Matsui W . (2010). Targeting hedgehog--a cancer stem cell pathway. Clin Cancer Res 16: 3130–3140.
Article CAS Google Scholar
- Metge BJ, Frost AR, King JA, Dyess DL, Welch DR, Samant RS et al. (2008). Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer. Clin Exp Metastasis 25: 753–763.
Article CAS Google Scholar
- Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, Page GP et al. (2006). Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. Cancer Biol Ther 5: 674–683.
Article CAS Google Scholar
- O'Toole SA, Machalek DA, Shearer RF, Millar EK, Nair R, Schofield P et al. (2011). Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Res 71: 4002–4014.
Article CAS Google Scholar
- Pola R, Ling LE, Silver M, Corbley MJ, Kearney M, Blake Pepinsky R et al. (2001). The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med 7: 706–711.
Article CAS Google Scholar
- Porter JA, von Kessler DP, Ekker SC, Young KE, Lee JJ, Moses K et al. (1995). The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374: 363–366.
Article CAS Google Scholar
- Renault MA, Roncalli J, Tongers J, Thorne T, Klyachko E, Misener S et al. (2010). Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells. J Mol Cell Cardiol 49: 490–498.
Article CAS Google Scholar
- Samant RS, Shevde LA . (2011). Recent advances in anti-angiogenic therapy of cancer. Oncotarget 2: 122–134.
Article Google Scholar
- Santner SJ, Dawson PJ, Tait L, Soule HD, Eliason J, Mohamed AN et al. (2001). Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Res Treat 65: 101–110.
Article CAS Google Scholar
- Shevde LA, Samant RS, Paik JC, Metge BJ, Chambers AF, Casey G et al. (2006). Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435. Clin Exp Metastasis 23: 123–133.
Article CAS Google Scholar
- Singh S, Varney M, Singh RK . (2009). Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis. Cancer Res 69: 411–415.
Article CAS Google Scholar
- Sun ZJ, Wang Y, Cai Z, Chen PP, Tong XJ, Xie D . (2008). Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells. Br J Cancer 99: 1656–1667.
Article CAS Google Scholar
- Trimmer C, Whitaker-Menezes D, Bonuccelli G, Milliman JN, Daumer KM, Aplin AE et al. (2010). CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway. Cancer Res 70: 7489–7499.
Article CAS Google Scholar
- Tsai MS, Bogart DF, Castaneda JM, Li P, Lupu R . (2002). Cyr61 promotes breast tumorigenesis and cancer progression. Oncogene 21: 8178–8185.
Article CAS Google Scholar
- Vokes SA, Yatskievych TA, Heimark RL, McMahon J, McMahon AP, Antin PB et al. (2004). Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131: 4371–4380.
Article CAS Google Scholar
- Weidner N, Semple JP, Welch WR, Folkman J . (1991). Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med 324: 1–8.
Article CAS Google Scholar
- Xie D, Miller CW, O'Kelly J, Nakachi K, Sakashita A, Said JW et al. (2001a). Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease. J Biol Chem 276: 14187–14194.
Article CAS Google Scholar
- Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP . (2001b). Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res 61: 8917–8923.
CAS PubMed Google Scholar
- Xie D, Yin D, Wang HJ, Liu GT, Elashoff R, Black K et al. (2004). Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas. Clin Cancer Res 10: 2072–2081.
Article CAS Google Scholar
- Yang L, Xie G, Fan Q, Xie J . (2010). Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 29: 469–481.
Article Google Scholar
- Zetter BR . (1998). Angiogenesis and tumor metastasis. Annu Rev Med 49: 407–424.
Article CAS Google Scholar
- Zhang RD, Fidler IJ, Price JE . (1991). Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. Invasion Metastasis 11: 204–215.
CAS PubMed Google Scholar
- Zhou ZQ, Cao WH, Xie JJ, Lin J, Shen ZY, Zhang QY et al. (2009). Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma. BMC Cancer 9: 291.
Article Google Scholar
- Zunich SM, Douglas T, Valdovinos M, Chang T, Bushman W, Walterhouse D et al. (2009). Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation. Mol Cancer 8: 12.
Article Google Scholar