Cbl-independent degradation of Met: ways to avoid agonism of bivalent Met-targeting antibody (original) (raw)
Crepaldi T, Pollack AL, Prat M, Zborek A, Mostov K, Comoglio PM . Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. J Cell Biol 1994; 125: 313–320. ArticleCAS Google Scholar
Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J 1991; 10: 2867–2878. ArticleCAS Google Scholar
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF . Met, metastasis, motility and more. Nat Rev Mol Cell Biol 2003; 4: 915–925. ArticleCAS Google Scholar
Comoglio PM, Boccaccio C . Scatter factors and invasive growth. Semin Cancer Biol 2001; 11: 153–165. ArticleCAS Google Scholar
Trusolino L, Bertotti A, Comoglio PM . MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 2010; 11: 834–848. ArticleCAS Google Scholar
Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S . The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Nature 2002; 416: 187–190. ArticleCAS Google Scholar
Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J et al. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest 2010; 120: 3617–3628. ArticleCAS Google Scholar
Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S et al. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature 2009; 460: 904–908. ArticleCAS Google Scholar
Ma PC, Kijima T, Maulik G, Fox EA, Sattler M, Griffin JD et al. c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res 2003; 63: 6272–6281. CAS Google Scholar
Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, Mitsudomi T . Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol 2009; 4: 5–11. Article Google Scholar
Kong-Beltran M, Seshagiri S, Zha J, Zhu W, Bhawe K, Mendoza N et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res 2006; 66: 283–289. ArticleCAS Google Scholar
Zang ZJ, Ong CK, Cutcutache I, Yu W, Zhang SL, Huang D et al. Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. Cancer Res 2011; 71: 29–39. ArticleCAS Google Scholar
Guo A, Villen J, Kornhauser J, Lee KA, Stokes MP, Rikova K et al. Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci USA 2008; 105: 692–697. ArticleCAS Google Scholar
Lai AZ, Durrant M, Zuo D, Ratcliffe CD, Park M . Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer. J Biol Chem 2012; 287: 8048–8059. ArticleCAS Google Scholar
Lefebvre J, Ancot F, Leroy C, Muharram G, Lemiere A, Tulasne D . Met degradation: more than one stone to shoot a receptor down. FASEB J 2012; 26: 1387–1399. ArticleCAS Google Scholar
Liu X, Newton RC, Scherle PA . Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med 2010; 16: 37–45. ArticleCAS Google Scholar
Smolen GA, Sordella R, Muir B, Mohapatra G, Barmettler A, Archibald H et al. Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci USA 2006; 103: 2316–2321. ArticleCAS Google Scholar
Foveau B, Ancot F, Leroy C, Petrelli A, Reiss K, Vingtdeux V et al. Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis. Mol Biol Cell 2009; 20: 2495–2507. ArticleCAS Google Scholar
Nakagawa T, Tohyama O, Yamaguchi A, Matsushima T, Takahashi K, Funasaka S et al. E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models. Cancer Sci 2010; 101: 210–215. ArticleCAS Google Scholar
Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V et al. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov 2012; 2: 270–287. ArticleCAS Google Scholar
Comoglio PM, Giordano S, Trusolino L . Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov 2008; 7: 504–516. ArticleCAS Google Scholar
Eder JP, Vande Woude GF, Boerner SA, LoRusso PM . Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res 2009; 15: 2207–2214. ArticleCAS Google Scholar
Peruzzi B, Bottaro DP . Targeting the c-Met signaling pathway in cancer. Clin Cancer Res 2006; 12: 3657–3660. ArticleCAS Google Scholar
Stellrecht CM, Gandhi V . MET receptor tyrosine kinase as a therapeutic anticancer target. Cancer Lett 2009; 280: 1–14. ArticleCAS Google Scholar
Vigna E, Pacchiana G, Mazzone M, Chiriaco C, Fontani L, Basilico C et al. ‘Active’ cancer immunotherapy by anti-Met antibody gene transfer. Cancer Res 2008; 68: 9176–9183. ArticleCAS Google Scholar
Jin H, Yang R, Zheng Z, Romero M, Ross J, Bou-Reslan H et al. MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res 2008; 68: 4360–4368. ArticleCAS Google Scholar
Hedman H, Henriksson R . LRIG inhibitors of growth factor signalling—double-edged swords in human cancer? Eur J Cancer 2007; 43: 676–682. ArticleCAS Google Scholar
Ordonez-Moran P, Huelsken J . Lrig1: a new master regulator of epithelial stem cells. EMBO J 2012; 31: 2064–2066. ArticleCAS Google Scholar
Shattuck DL, Miller JK, Laederich M, Funes M, Petersen H, Carraway KL et al. LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy. Mol Cell Biol 2007; 27: 1934–1946. ArticleCAS Google Scholar
Krumbach R, Schuler J, Hofmann M, Giesemann T, Fiebig HH, Beckers T . Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: activation of MET as one mechanism for drug resistance. Eur J Cancer 2011; 47: 1231–1243. ArticleCAS Google Scholar
Oh YM, Song Y, Lee SB, Jeong Y, Kim B, Kim GW et al. A novel anti-c-Met antibody: therapeutic potential in cancer. Mol Cells (accepted).
Stutz MA, Shattuck DL, Laederich MB, Carraway KL, Sweeney C . LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII. Oncogene 2008; 27: 5741–5752. ArticleCAS Google Scholar
Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S et al. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol 2012; 14: 401–408. ArticleCAS Google Scholar
Benvenuti S, Comoglio PM . The MET receptor tyrosine kinase in invasion and metastasis. J Cell Physiol 2007; 213: 316–325. ArticleCAS Google Scholar
Hanahan D, Weinberg RA . Hallmarks of cancer: the next generation. Cell 2011; 144: 646–674. ArticleCAS Google Scholar
Petrelli A, Circosta P, Granziero L, Mazzone M, Pisacane A, Fenoglio S et al. Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity. Proc Natl Acad Sci USA 2006; 103: 5090–5095. ArticleCAS Google Scholar
Pacchiana G, Chiriaco C, Stella MC, Petronzelli F, De Santis R, Galluzzo M et al. Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody. J Biol Chem 2010; 285: 36149–36157. ArticleCAS Google Scholar
Schelter F, Kobuch J, Moss ML, Becherer JD, Comoglio PM, Boccaccio C et al. A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor. J Biol Chem 2010; 285: 26335–26340. ArticleCAS Google Scholar
Ancot F, Leroy C, Muharram G, Lefebvre J, Vicogne J, Lemiere A et al. Shedding-Generated Met Receptor Fragments can be Routed to Either the Proteasomal or the Lysosomal Degradation Pathway. Traffic 2012; 13: 1261–1272. ArticleCAS Google Scholar
Greenall SA, Gherardi E, Liu Z, Donoghue JF, Vitali AA, Li Q et al. Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET. PLoS One 2012; 7: e34658. ArticleCAS Google Scholar
Asaoka Y, Tada M, Ikenoue T, Seto M, Imai M, Miyabayashi K et al. Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion. Biochem Biophys Res Commun 2010; 394: 1042–1046. ArticleCAS Google Scholar
Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 2007; 104: 20932–20937. ArticleCAS Google Scholar
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316: 1039–1043. ArticleCAS Google Scholar
Hamburger AW, Salmon SE . Primary bioassay of human tumor stem cells. Science 1977; 197: 461–463. ArticleCAS Google Scholar