- Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ . Viral hepatocarcinogenesis: from infection to cancer. Liver Int 2008; 28: 175–188.
Article CAS Google Scholar
- Lupberger J, Hildt E . Hepatitis B virus-induced oncogenesis. World J Gastroenterol 2007; 13: 74–81.
Article CAS Google Scholar
- Wang Y, Cui F, Lv Y, Li C, Xu X, Deng C et al. HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology 2004; 39: 318–324.
Article CAS Google Scholar
- Hanahan D, Weinberg R . The hallmarks of cancer. Cell 2000; 100: 57–70.
Article CAS Google Scholar
- Buendia A . Genetics of hepatocellular carcinoma. Semin Cancer Biol 2000; 10: 185–200.
Article CAS Google Scholar
- Ozaki I, Mizuta T, Zhao G, Yotsumoto H, Hara T, Kajihara S et al. Involvement of the Ets-1 gene in overexpression of matrilysin in human hepatocellular carcinoma. Cancer Res 2000; 60: 6519–6525.
CAS PubMed Google Scholar
- Huang JZ, Xia SS, Ye QF, Jiang HY, Chen ZH . Effects of p16 gene on biological behavious in hepatocellular carcimoma cells. World J Gastroenterol 2003; 9: 84–88.
Article CAS Google Scholar
- Zhang H, Ozaki I, Mizuta T, Hamajima H, Yasutake T, Eguchi Y et al. Involvement of programmed cell death 4 in transforming growth factor-β1-induced apoptosis in human hepatocellular carcinoma. Oncogene 2006; 25: 6101–6112.
Article CAS Google Scholar
- Soejima K, Fang W, Rollins BJ . DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras. Oncogene 2003; 22: 4723–4733.
Article CAS Google Scholar
- Tsai CN, Tsai CL, Tse KP, Chang HY, Chang YS . The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases. Proc Natl Acad Sci USA 2002; 99: 10084–10089.
Article CAS Google Scholar
- Lok AS, Heathcote EJ, Hoofnagle JH . Management of hepatitis B: 2000-summary of a workshop. Gastroenterology 2001; 120: 1828–1853.
Article CAS Google Scholar
- Lee JO, Kwun HJ, Jung JK, Choi KH, Min DS, Jang KL . Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene 2005; 24: 6617–6625.
Article CAS Google Scholar
- Park IY, Sohn BH, Yu E, Suh DJ, Chung YH, Lee JH et al. Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology 2007; 132: 1476–1494.
Article CAS Google Scholar
- Wang Y, Lu Y, Toh ST, Sung WK, Tan P, Chow P et al. Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. J Hepatol 2010; 53: 57–66.
Article CAS Google Scholar
- Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2005; 25: 2537–2545.
Article Google Scholar
- Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, Rebouissou S et al. MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 2008; 47: 1955–1963.
Article CAS Google Scholar
- Hajjou M, Norel R, Carver R, Marion P, Cullen J, Rogler LE et al. cDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV. J Med Virol 2005; 77: 57–65.
Article CAS Google Scholar
- Okabe H, Satoh S, Kato T, Kitahara O, Yanagawa R, Yamaoka Y et al. Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray. Cancer Res 2001; 61: 2129–2137.
CAS Google Scholar
- Gao F, Wang X, Zhu F, Wang Q, Zhang X, Guo C et al. PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavourable prognosis. J Cell Mol Med 2009; 13: 4257–4267.
Article CAS Google Scholar
- Fan H, Zhao Z, Quan Y, Xu J, Zhang J, Xie W . DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721. Eur J Gastroenterol Hepatol 2007; 19: 952–961.
Article CAS Google Scholar
- Asangani I, Rasheed S, Nikolova D, Leupold J, Colburn N, Post S et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2007; 27: 2128–2136.
Article Google Scholar
- Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH . Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 2008; 283: 1026–1033.
Article CAS Google Scholar
- Zhang X, Liu S, Hu T, He Y, Sun S . Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression. Hepatology 2009; 50: 490–499.
Article CAS Google Scholar
- Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X . Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model. PLoS One 2011; 6: e19518.
Article CAS Google Scholar
- Matsuhashi S, Yoshinaga H, Yatsuki H, Tsugita A, Hori K . Isolation of a novel gene from a human cell line with Pr-28 MAb which recognizes a nuclear antigen involved in the cell cycle. Res Commun Biochem Cell Mol Biol 1997; 1: 109–120.
CAS Google Scholar
- Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z . Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. Pathol Int 1999; 49: 1067–1077.
Article CAS Google Scholar
- Wang Q, Sun Z, Yang H . Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both β-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells. Oncogene 2007; 27: 1527–1535.
Article Google Scholar
- Zhang S, Li J, Jiang Y, Xu Y, Qin C . Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells. J Exp Clin Cancer Res 2009; 28: 1–11.
Article Google Scholar
- Hilliard A, Hilliard B, Zheng SJ, Sun H, Miwa T, Song W et al. Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. J Immunol 2006; 177: 8095–8102.
Article CAS Google Scholar
- Schmid T, Jansen AP, Baker AR, Hegamyer G, Hagan JP, Colburn NH . Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion. Cancer Res 2008; 68: 1254–1260.
Article CAS Google Scholar
- Jansen AP, Camalier CE, Colburn NH . Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res 2005; 65: 6034–6041.
Article CAS Google Scholar
- Zhang X, Wang X, Song X, Liu C, Shi Y, Wang Y et al. Programmed cell death 4 enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway in vitro and in vivo. Cancer Sci 2010; 10: 2163–2170.
Article Google Scholar
- Lankat-Buttgereit B, Goke R . Programmed cell death protein 4 (pdcd4): A novel target for antineoplastic therapy? Biol Cell 2003; 95: 515–520.
Article CAS Google Scholar
- Ozturk M . Genetic aspects of hepatocellular carcinogenesis. Semin Liver Dis 1999; 19: 235–242.
Article CAS Google Scholar
- Kusano N, Shiraishi K, Kubo K, Oga A, Okita K, Sasaki K . Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology 1999; 29: 1858–1862.
Article CAS Google Scholar
- Yu MW, Chen CJ . Hepatitis B and C viruses in the development of hepatocellular carcinoma. Crit Rev Oncol Hematol 1994; 17: 71–91.
Article CAS Google Scholar
- Zheng DL, Zhang L, Cheng N, Xu X, Deng Q, Teng XM et al. Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. J Hepatol 2009; 50: 377–387.
Article CAS Google Scholar
- Li J, Fu H, Xu C, Tie Y, Xing R, Zhu J et al. miR-183 inhibits TGF-β1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells. BMC Cancer 2010; 10: 354–363.
Article Google Scholar
- Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M . S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 2006; 314: 467–471.
Article CAS Google Scholar
- Luber B, Lauer U, Weiss L, Höhne M, Hofschneider PH, Kekulé AS . The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C. Res Virol 1993; 144: 311–321.
Article CAS Google Scholar
- Tanaka Y, Kanai F, Ichimura T, Tateishi K, Asaoka Y, Guleng B et al. The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1. Oncogene 2006; 25: 633–642.
Article CAS Google Scholar
- Talotta F, Cimmino A, Matarazzo MR, Casalino L, De Vita G, D'Esposito M et al. An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation. Oncogene 2009; 28: 73–84.
Article CAS Google Scholar
- Yang HS, AP Jansen, Nair R, Shibahara K, Verma AK, Cmarik JL et al. A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation. Oncogene 2001; 20: 669–676.
Article CAS Google Scholar
- Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005; 33: e179.
Article Google Scholar
- Si M, Zhu S, Wu H, Lu Z, Wu F, Mo Y . miR-21-mediated tumor growth. Oncogene 2006; 26: 2799–2803.
Article Google Scholar
- Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB . Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93: 9821–9826.
Article CAS Google Scholar
- Leupold JH, Asangani IA, Mudduluru G, Allgayer H . Promoter cloning and characterization of the human programmed cell death protein 4 (pdcd4) gene: evidence for ZBP-89 and Sp-binding motifs as essential Pdcd4 regulators. Biosci Rep 2012; 32: 281–297.
Article CAS Google Scholar