- Lu P, Weaver V, Werb Z . The extracellular matrix: A dynamic niche in cancer progression. J Cell Biol 2012; 196: 395–406.
Article CAS Google Scholar
- Nguyen D, Bos P, Massague J . Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009; 9: 274–285.
Article CAS Google Scholar
- Deng J, Liu Y, Lee H, Herrmann A, Zhang W, Zhang C et al. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 2012; 21: 642–654.
Article CAS Google Scholar
- Peinado H, Aleckovic M, Lovotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012; 18: 883–891.
Article CAS Google Scholar
- Sceneay J, Smyth M, Moller A . The pre-metastatic niche: finding common ground. Cancer Metastasis Rev 2013; 32: 449–464.
Article CAS Google Scholar
- Orimo A, Gupta P, Sgroi D, Arenzana-Seisdedos F, Delaunay T, Naeem R et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121: 335–348.
Article CAS Google Scholar
- Zhang X, Jin X, Malladi S, Zou Y, Wen Y, Brogi E et al. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell 2013; 154: 1060–1073.
Article CAS Google Scholar
- Duda D, Duyverman A, Kohno M, Snuder M, Steller E, Fukumura D et al. Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci USA 2010; 107: 21677–21682.
Article CAS Google Scholar
- Padua D, Zhang X, Wang Q, Nadal C, Gerald W, Gomis R et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008; 133: 66–77.
Article CAS Google Scholar
- Erler J, Bennewith K, Cox T, Lang G, Bird D, Koong A et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche. Cancer Cell. 2009; 15: 35–44.
Article CAS Google Scholar
- Luker K, Luker G . Functions of CXCL12 and CXCR4 in breast cancer. Cancer Lett 2006; 238: 30–41.
Article CAS Google Scholar
- Duda D, Kozin S, Kirkpatrick N, Xu L, Fukumura D, Jain R . CXCL12 (SDF1{alpha})—CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anti-cancer therapies? Clin Cancer Res 2011; 17: 2074–2080.
Article CAS Google Scholar
- Muller A, Homey B, Soto H, Ge N, Catron D, Buchanon M et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410: 50–56.
Article CAS Google Scholar
- Smith M, Luker K, Garbow J, Prior J, Jackson E, Piwnica-Worms D et al. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004; 64: 8604–8612.
Article CAS Google Scholar
- Zhang S, Han Z, Jing Y, Tao S, Li T, Wang H et al. CD133+CXCR4+ colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. BMC Med 2012; 10: 85.
Article Google Scholar
- Jung Y, Kim J, Shiozawa Y, Wang J, Mishra A, Joseph J et al. Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun 2013; 4: 1795.
Article Google Scholar
- Zetter B . Angiogenesis and tumor metastasis. Ann Rev Med 1998; 49: 407–424.
Article CAS Google Scholar
- Guo P, Xu L, Pan S, Brekken R, Yang S, Whitaker G et al. Vascular endothelial growth factor isoforms display distinct activities in promoting tumor angiogenesis at different anatomic sites. Cancer Res 2001; 61: 8569–8577.
CAS Google Scholar
- Kloen P, Gebhardt M, Perez-Atayde A, Rosenberg A, Springfield D, Gold L et al. Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. Cancer 1997; 80: 2230–2239.
Article CAS Google Scholar
- Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara K et al. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 1995; 28: 495–500.
Article CAS Google Scholar
- Yu L, Cecil J, Peng S, Schrementi J, Kovacevic S, Paul D et al. Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene 2006; 374: 174–179.
Article CAS Google Scholar
- Laguri C, Sadir R, Rueda P, Baleux F, Gans P, Arenzana-Seisdedos F et al. The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4. PLoS One 2007; 2: e1110.
Article Google Scholar
- Stumm R, Kolodziej A, Schulz S, Kohtz J, Hollt V . Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon. J Comp Neurol 2007; 502: 382–399.
Article CAS Google Scholar
- Gahan J, Gasalbez M, Yates T, Young E, Escudero D, Chi A et al. Chemokine and chemokine receptor expression in kidney tumors: molecular profiling of histological subtypes and association with metastasis. J Urol 2012; 187: 827–833.
Article CAS Google Scholar
- Park H, Min S, Cho H, Kim D, Shin H, Park Y . Expression of osteoprotegerin and RANK ligand in breast cancer bone metastasis. J Korean Med Sci 2003; 18: 541–546.
Article CAS Google Scholar
- Luker K, Gupta M, Luker G . Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7. Biotechniques 2009; 47: 625–632.
Article CAS Google Scholar
- Cavnar S, Ray P, Moudgil P, Chang S, Luker K, Linderman J et al. Microfluidic source-sink model reveals effects of biophysically distinct CXCL12-isoforms in breast cancer chemotaxis. Integr Biol 2014; 6: 564–576.
Article CAS Google Scholar
- Luker K, Gupta M, Luker G . Imaging CXCR4 signaling with firefly luciferase complementation. Anal Chem 2008; 80: 5565–5573.
Article CAS Google Scholar
- Salcedo R, Oppenheim J . Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses. Microcirculation 2003; 10: 359–370.
Article CAS Google Scholar
- Ho T, Tsui J, Xu S, Abraham D, Baker D . Angiogenic effects of stromal cell-derived factor-1 (SDF-1/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia. J Vasc Surg 2010; 51: 689–699.
Article Google Scholar
- Luker K, Gupta M, Steele J, Foerster B, Luker G . Imaging ligand-dependenta activation of CXCR7. Neoplasia 2009; 11: 1022–1035.
Article CAS Google Scholar
- Brown J, Zhang J, Keller E . Opg, RANKL, and RANK in cancer metastasis: expression and regulation. Cancer Treat Res 2004; 118: 149–172.
Article CAS Google Scholar
- Udagawa N, Takahashi N, Jimi E, Matsuzaki K, Tsurukai T, Itoh K et al. Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand. Bone 1999; 25: 517–523.
Article CAS Google Scholar
- Rueda P, Richart A, Recalde A, Gasse P, Vilar J, Guerin C et al. Homeostatic and tissue reparation defecs in mice carrying selective genetic invalidation of CXCL12/proteolycan interactions. Circulation 2012; 126: 1882–1895.
Article CAS Google Scholar
- Altenburg J, Broxmeyer H, Jin Q, Cooper S, Basu S, Alkhatib G . A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities. J Virol 2007; 81: 8140–8148.
Article CAS Google Scholar
- Rueda P, Balabanian K, Lagane B, Staropoli I, Chow K, Levoye A et al. The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins. PLoS One 2008; 3: e2543.
Article Google Scholar
- Zannettino A, Farrugia A, Kortesidis A, Manavis J, To L, Martin S et al. Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res 2005; 65: 1700–1709.
Article CAS Google Scholar
- Kim H, Kim K, Kim B, Jung H, Cho M, Lee S . Reciprocal activation of CD4+T cells and synovial fibroblasts by SDF-1 promotes RANKL expression and osteoclastogenesis in rheumatoid arthritis. Arthritis Rheum 2013; 66: 538–548.
Article Google Scholar
- Luker K, Lewin S, Mihalko L, Schmidt B, Winkler J, Coggins N et al. Scavenging of CXCL12 by CXCR7 regulates tumor growth and metastasis of CXCR4-positive breast cancer cells. Oncogene 2012; 31: 4570–4578.
Article Google Scholar
- Venkiteswaran G, Lewellis S, Wang J, Reynolds E, Nicholson C, Knaut H . Generation and dynamics of an endogenous, self-generated signaling gradient across a migrating tissue. Cell 2013; 155: 674–687.
Article CAS Google Scholar
- Dona E, Barry J, Valentin G, Quirin C, Khmelinskii A, Kunze A et al. Directional tissue migration through a self-generated chemokine gradient. Nature 2013; 503: 285–289.
Article CAS Google Scholar
- Odemis Y, Lipfert J, Kraft R, Hajek P, Abraham G, Hattermann K et al. The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells. Glia 2012; 60: 372–381.
Article Google Scholar
- Rajagopal S, Kim J, Ahn S, Craig S, Lam C, Gerard N et al. Beta-arrestin- but not G protein-mediated signaling by the ‘decoy’ receptor CXCR7. Proc Natl Acad Sci USA 2010; 107: 628–632.
Article Google Scholar
- Levesque J-P, Hendy J, Takamatsu Y, Simmons P, Bendall L . Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 2003; 111: 187–196.
Article CAS Google Scholar
- Diamond P, Labrinidis A, Martin S, Farrugia A, Gronthos S, To L et al. Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss. J Bone Miner Res 2009; 24: 1150–1161.
Article CAS Google Scholar
- Shu H, Yoon Y, Hong S, Xu K, Gao H, Hao C et al. Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis. PLoS One 2013; 8: e79768.
Article CAS Google Scholar
- Chu Q, Panu L, Holm N, Li B, Johnson L, Zhang S . High chemokine receptor CXCR4 level in triple negative breast cancer specimens predicts poor clinical outcome. J Surg Res 2010; 159: 689–695.
Article CAS Google Scholar
- Chueh B, Huh D, Kyrtsos C, Houssin T, Futai N, Takayama S . Leakage-free bonding of porous membranes into layered microfluidic array systems. Anal Chem 2007; 79: 3504–3508.
Article CAS Google Scholar
- Ebos J, Lee C, Christensen J, Mutsaers A, Kerbel R . Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci USA 2007; 104: 17069–17074.
Article CAS Google Scholar
- Holland J, Gyorffy B, Vogel R, Eckert K, Valenti G, Fang L et al. Combined Wnt/β-catenin, met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome. Cell Rep 2013; pii S2211-1247: 00649–00649.
Google Scholar
- Nixon A, Pang H, Starr M, Friedman P, Bertagnoli M, Kindler H et al. Prognostic and predictive blood-based biomarkers in patients with advanced pancreatic cancer: results from CALGB80303 (Alliance). Clin Cancer Res 2013; 19: 6957–6966.
Article CAS Google Scholar
- Song J, Cavnar S, Walker A, Luker K, Gupta M, Tung Y et al. Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS One 2009; 4: e5756.
Article Google Scholar
- Lois C, Hong E, Pease S, Brown E, Baltimore D . Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 2002; 295: 868–872.
Article CAS Google Scholar
- Shcherbo D, Shemiakina I, Ryabova A, Luker K, Schmidt B, Souslova E et al. Near infrared fluorescent proteins. Nat Methods 2010; 7: 827–829.
Article CAS Google Scholar
- Ray P, Mihalko L, Coggins N, Moudgil P, Ehrlich A, Luker K et al. Carboxy-terminus of CXCR7 regulates receptor localization and function. Int J Biochem Cell Biol 44: 669–678.
Article CAS Google Scholar