Preclinical evaluation of the cardiac toxicity of HMR-1826, a novel prodrug of doxorubicin (original) (raw)

References

• Baurain, R, Deprez-De Campaneere, D & Trouet, A (1979). Rapid determination of doxorubicin and its fluorescent metabolites by high pressure liquid chromatography. Anal Biochem 94: 112–116.
  Article CAS Google Scholar
• Bosslet, K, Straub, R, Blumrich, M, Czech, J, Gerken, M, Sperker, B, Kroemer, HK, Gesson, JP, Koch, M & Monneret, C (1998). Elucidation of the mechanism enabling tumor selective prodrug monotherapy. Cancer Res 58: 1195–1201.
  CAS PubMed Google Scholar
• Connors, TA & Whisson, ME (1966). Cure of mice bearing advanced plasma cell tumours with aniline mustard: the relationship between glucuronidase activity and tumour sensitivity. Nature 210: 866–867.
  Article CAS Google Scholar
• Duncan, R, Coatsworth, JK & Burtles, S (1998). Preclinical toxicology of a novel polymeric antitumour agent: HPMA copolymer-doxorubicin (PK1). Human Exp Toxicol 17: 93–104.
  CAS Google Scholar
• Florent, JC, Gaudel, G, Mitaku, S, Monneret, C, Gesson, JP, Jacquesy, JC, Mondon, J, Martine, C, Renoux, B, Adrianomenjanahary, S, Michel, S, Koch, M, Tillequin, F, Gerken, M, Czech, J, Straub, R & Bosslet, K (1998). Prodrugs of anthracyclines for use in antibody-directed enzyme prodrug therapy. J Med Chem 41: 3572–3581.
  Article CAS Google Scholar
• Lorell, BH, Wexler, LF, Momomura, S, Weinberg, E & Apstein, CS (1986). The influence of pressure overload left ventricular hypertrophy on diastolic properties during hypoxia in isovolumically contracting rat hearts. Circ Res 58: 653–663.
  Article CAS Google Scholar
• Mouridsen, HT (1992). Systemic therapy for advanced breast cancer. Drugs 44: 17–28.
  Article Google Scholar
• Muerdter, TE, Sperker, B, Kivistö, KT, McClellan, M, Fritz, P, Friedel, G, Linder, A, Bosslet, K, Toomes, H, Dierkesmann, R & Kroemer, HK (1997). Enhanced uptake of doxorubicin into bronchial carcinoma: β-glucuronidase mediates release of doxorubicin from a glucuronide prodrug. Cancer Res 57: 2440–2445.
  Google Scholar
• Pouna, P, Bonoron-Adèle, S, Gouverneur, G, Tariosse, L, Besse, P & Robert, J (1996). Development of the model of rat isolated perfused heart for the evaluation of anthracycline cardiotoxicity and its circumvention. Br J Pharmacol 117: 1593–1599.
  Article CAS Google Scholar
• Von Hoff, DD, Layard, MW, Basa, P, Davis, HL, Von Hoff, AL, Rozencweig, M & Muggia, FM (1979). Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 91: 710–717.
  Article CAS Google Scholar
• Working, PK & Dayan, AD (1996). Pharmacological-toxicological expert report: Caelyx™ (Stealth® liposomal doxorubicin HCl). Human Exp Toxicol 15: 752–785.
  Article Google Scholar

Download references