A new cell therapy registry coordinated by the European Group for Blood and Marrow Transplantation (EBMT) (original) (raw)

Bone Marrow Transplantation volume 41, page 319 (2008)Cite this article

Novel cell therapies include cell preparations defined by various criteria and may be applicable to patients suffering from autoimmune, neurologic and hematologic disorders as well as heart diseases and so on. The therapeutic potential of, for example, cytotoxic T cells, tumor vaccines and mesenchymal stem cells (MSCs) is undergoing extensive clinical testing in areas such as cancer, tissue repair in connective tissue disorders and heart repair as well as immune modulation in the setting of stem cell transplantation. In other areas, including immunological disorders such as rheumatoid arthritis and vasculitides, MSC treatment is about to enter the clinical arena.

Although these therapies may be promising and prove to be of clinical use, clinical trials are often small with a limited follow-up. Detection of long-term beneficial effects, as well as late and rare side effects, would require a large number of patients followed over many years. Little is known of the in vivo risks of infused cell products manipulated or expanded ex vivo. A risk of ectopic tissue formation, malignant transformation of the cell product or secondary malignancies, as observed occasionally in certain experimental animal models, may or may not pose true clinical risks.

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Authors and Affiliations

  1. Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    K Le Blanc
  2. Hematology Center, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    K Le Blanc
  3. Department of Immunohematology and Bloodbank, Leiden University Medical Center, Leiden, The Netherlands. E-mail: katarina.Leblanc@ki.se,
    W Fibbe

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on behalf of the Developmental Committee of the EBMT

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Le Blanc, K., Fibbe, W. & on behalf of the Developmental Committee of the EBMT. A new cell therapy registry coordinated by the European Group for Blood and Marrow Transplantation (EBMT).Bone Marrow Transplant 41, 319 (2008). https://doi.org/10.1038/sj.bmt.1705920

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