The role of phosphatidylserine in recognition of apoptotic cells by phagocytes (original) (raw)

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• Published: 10 July 1998

Cell Death & Differentiation volume 5, pages 551–562 (1998)Cite this article

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Abstract

Exposure of phosphatidylserine on the outer leaflet of the plasma membrane is a surface change common to many apoptotic cells. Normally restricted to the inner leaflet, phosphatidylserine appears as a result of decreased aminophospholipid translocase activity and activation of a calcium-dependent scramblase. Phosphatidylserine exposure has several potential biological consequences, one of which is recognition and removal of the apoptotic cell by phagocytes. It is still not clear which receptors mediate PS recognition on apoptotic cells; however, several interesting candidates have been proposed. These include the Class B scavenger and thrombospondin receptor CD36, an oxLDL receptor (CD68), CD14, annexins, β2 glycoprotein I, gas-6 and a novel activity expressed on macrophages stimulated with digestible particles such as β-glucan. Whether PS is the sole ligand recognized by phagocytes or whether it associated with other molecules to form a complex ligand remains to be determined.

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Authors and Affiliations

1. Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, 80206, Colorado, USA
   Valerie A Fadok, Donna L Bratton, S Courtney Frasch, Mary L Warner & Peter M Henson

Authors

1. Valerie A Fadok
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2. Donna L Bratton
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3. S Courtney Frasch
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4. Mary L Warner
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5. Peter M Henson
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Correspondence toValerie A Fadok.

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Edited by M. Piacentini

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Fadok, V., Bratton, D., Frasch, S. et al. The role of phosphatidylserine in recognition of apoptotic cells by phagocytes.Cell Death Differ 5, 551–562 (1998). https://doi.org/10.1038/sj.cdd.4400404

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• Received: 15 October 1997
• Revised: 23 March 1998
• Accepted: 02 April 1998
• Published: 10 July 1998
• Issue Date: 01 July 1998
• DOI: https://doi.org/10.1038/sj.cdd.4400404

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