Possible role of NF-κB and p53 in the glutamate-induced pro-apoptotic neuronal pathway (original) (raw)

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• Published: 11 January 1999

Cell Death & Differentiation volume 6, pages 22–27 (1999)Cite this article

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Abstract

Apoptosis is now recognized as an important component in many progressive and acute neurodegenerative diseases. Extracellular signals and intracellular mechanisms triggering and regulating apoptosis in neuronal cells are still a matter of investigation. Here we review data from our and other laboratories with the aim to elucidate the nature of some proteins which are known to be involved in cell cycle regulation as well as in promoting degeneration and apoptosis of neurons. The following molecules will be taken into consideration: NF-κB, p53, p21 and MSH2. These proteins are activated by neurotoxic experimental conditions which involve the stimulation of selective receptors for the excitatory aminoacid glutamate. Thus, we hypothesize their contribution to an intracellular pathway responsible for the glutamate-induced neuronal death. Identification of such mechanisms could be relevant for understanding the apoptosis associated with various neurodegenerative diseases as well as for developing novel strategies of pharmacological intervention.

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Authors and Affiliations

1. Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Brescia, Italy
   Maurizio Memo
2. Schering-Plough Research Institute, San Raffaele Science Park, Milan, Italy
   Mariagrazia Grilli

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1. Mariagrazia Grilli
2. Maurizio Memo

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Correspondence toMaurizio Memo.

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Edited by G. Melino

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Grilli, M., Memo, M. Possible role of NF-κB and p53 in the glutamate-induced pro-apoptotic neuronal pathway.Cell Death Differ 6, 22–27 (1999). https://doi.org/10.1038/sj.cdd.4400463

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• Received: 25 August 1998
• Revised: 24 September 1998
• Accepted: 12 October 1998
• Published: 11 January 1999
• Issue date: 01 January 1999
• DOI: https://doi.org/10.1038/sj.cdd.4400463

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