Westermann F and Schwab M (2002) Genetic parameters of neuroblastomas. Cancer Lett.184: 127–147 ArticleCASPubMed Google Scholar
Kim PK, Mahidhara R and Seol DW (2001) The role of caspase-8 in resistance to cancer chemotherapy. Drug Resist. Update.4: 293–296 ArticleCAS Google Scholar
Teitz T, Lahti JM and Kidd VJ (2001) Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death. J. Mol. Med.79: 428–436 ArticleCASPubMed Google Scholar
van Golen CM and Feldman EL (2000) Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J. Cell. Physiol.182: 24–32 ArticleCASPubMed Google Scholar
van Golen CM, Castle VP and Feldman EL (2000) IGF-I receptor activation and Bcl-2 overexpression prevent early apoptotic events in human neuroblastoma. Cell Death Differ.7: 654–665 ArticleCASPubMed Google Scholar
Adams TE, Epa VC, Garrett TP and Ward CW (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell. Mol. Life Sci.57: 1050–1093 ArticleCASPubMed Google Scholar
Nechushtan A, Smith CL, Hsu YT and Youle RJ (1999) Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J.18: 2330–2341 ArticleCASPubMedPubMed Central Google Scholar
Baserga R (2000) The contradictions of the insulin-like growth factor 1 receptor. Oncogene19: 5574–5581 ArticleCASPubMed Google Scholar
Singleton JR, Randolph AE and Feldman EL (1996) Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis. Cancer Res.56: 4522–4529 CASPubMed Google Scholar
Surmacz E, Guvakova MA, Nolan MK, Nicosia RF and Sciacca L (1998) Type I insulin-like growth factor receptor function in breast cancer. Breast Cancer Res. Treat.47: 255–267 ArticleCASPubMed Google Scholar
Butler AA, Blakesley VA, Tsokos M, Pouliki V, Wood TL and LeRoith D (1998) Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression. Cancer Res.58: 3021–3027 CASPubMed Google Scholar
Sullivan KA, Castle VP, Hanash SM and Feldman EL (1995) Insulin-like growth factor II in the pathogenesis of human neuroblastoma. Am. J. Pathol.147: 1790–1798 CASPubMedPubMed Central Google Scholar
Leventhal PS, Randolph AE, Vesbit TE, Schenone A, Windebank AJ and Feldman EL (1995) Insulin-like growth factor-II as a paracrine growth factor in human neuroblastoma cells. Exp. Cell Res.221: 179–186 ArticleCASPubMed Google Scholar
Kiess W, Koepf G, Christiansen H and Blum WF (1997) Human neuroblastoma cells use either insulin-like growth factor-I or insulin-like growth factor-II in an autocrine pathway via the IGF-I receptor: variability of IGF, IGF binding protein (IGFBP) and IGF receptor gene expression and IGF and IGFBP secretion in human neuroblastoma cells in relation to cellular proliferation. Regul. Pept.72: 19–29 ArticleCASPubMed Google Scholar
Liu X, Turbyville T, Fritz A and Whitesell L (1998) Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice. Cancer Res.58: 5432–5438 CASPubMed Google Scholar
Singleton JR, Dixit VM and Feldman EL (1996) Type I insulin-like growth factor receptor activation regulates apoptotic proteins. J. Biol. Chem.271: 31791–31794 ArticleCASPubMed Google Scholar
Matthews CC, Odeh H and Feldman EL (1997) Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells. Neuroscience79: 525–534 ArticleCASPubMed Google Scholar
van Golen CM, Schwab TS, Woods Ignatoski KM, Ethier SP and Feldman EL (2001) PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell Growth Differ.12: 371–378 CASPubMed Google Scholar
Blakesley VA, Stannard BS, Kalebic T, Helman LJ and LeRoith D (1997) Role of the IGF-I receptor in mutagenesis and tumor promotion. J. Endocrinol.152: 339–344 ArticleCASPubMed Google Scholar
Werner H (1998) Dysregulation of the type 1 IGF receptor as a paradigm in tumor progression. Mol. Cell. Endocrinol.141: 1–5 ArticleCASPubMed Google Scholar
Scotlandi K, Maini C, Manara MC, Benini S, Serra M, Cerisano V, Strammiello R, Baldini N, Lollini PL, Nanni P, Nicoletti G and Picci P (2002) Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells. Cancer Gene Ther.9: 296–307 ArticleCASPubMed Google Scholar
Li S, Ferber A, Miura M and Baserga R (1994) Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain. J. Biol. Chem.269: 32558–32564 ArticleCASPubMed Google Scholar
Kroemer G, Zamzami N and Susin SA (1997) Mitochondrial control of apoptosis. Immunol. Today18: 44–51 ArticleCASPubMed Google Scholar
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prevost MC, Alzari PM and Kroemer G (1999) Mitochondrial release of caspase-2 and -9 during the apoptotic process. J. Exp. Med.189: 381–394 ArticleCASPubMedPubMed Central Google Scholar
Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT and Thompson CB (1997) Bcl-xl regulates the membrane potential and volume homeostasis of mitochondria. Cell91: 627–637 ArticleCASPubMed Google Scholar
Vander Heiden MG, Chandel NS, Li XX, Schumacker PT, Colombini M and Thompson CB (2000) Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc. Natl. Acad. Sci. USA97: 4666–4671 ArticleCASPubMedPubMed Central Google Scholar
Bossy-Wetzel E, Newmeyer DD and Green DR (1998) Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J.17: 37–49 ArticleCASPubMedPubMed Central Google Scholar
Deshmukh M and Johnson EM (1998) Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c. Neuron21: 695–705 ArticleCASPubMed Google Scholar
Budd SL, Tenneti L, Lishnak T and Lipton SA (2000) Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proc. Natl. Acad. Sci. USA97: 6161–6166 ArticleCASPubMedPubMed Central Google Scholar
Luetjens CM, Bui NT, Sengpiel B, Munstermann G, Poppe M, Krohn AJ, Bauerbach E, Krieglstein J and Prehan JH (2000) Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production. J. Neurosci.20: 5715–5723 ArticleCASPubMedPubMed Central Google Scholar
Villa P, Kaufmann SH and Earnshaw WC (1997) Caspases and caspase inhibitors. Trends Biochem. Sci.22: 388–393 ArticleCASPubMed Google Scholar
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES and Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell91: 479–489 ArticleCASPubMed Google Scholar
Pan G, O’Rourke K and Dixit VM (1998) Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J. Biol. Chem.273: 5841–5845 ArticleCASPubMed Google Scholar
Zou H, Henzel WJ, Liu X, Lutschg A and Wang X (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome _c_-dependent activation of caspase-3. Cell90: 405–413 ArticleCASPubMed Google Scholar
Maruyama W, Yamamoto T, Kitani K, Carrillo MC, Youdim M and Naoi M (2000) Mechanism underlying anti-apoptotic activity of a (−)deprenyl-related propargylamine, rasagiline. Mech. Ageing Dev.116: 181–191 ArticleCASPubMed Google Scholar
Moriya R, Uehara T and Nomura Y (2000) Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett.484: 253–260 ArticleCASPubMed Google Scholar
Ronot X, Benel L, Adolphe M and Mounolou JC (1986) Mitochondrial analysis in living cells: the use of rhodamine 123 and flow cytometry. Biol. Cell57: 1–7 ArticleCASPubMed Google Scholar
Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods139: 271–279 ArticleCASPubMed Google Scholar
Matthews CC and Feldman EL (1996) Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death. J. Cell. Physiol.166: 323–331 ArticleCASPubMed Google Scholar
Zamzami N, El Hamel C, Maisse C, Brenner C, Munoz-Pinedo C, Belzacq AS, Costantini P, Vieira H, Loeffler M, Molle G and Kroemer G (2000) Bid acts on the permeability transition pore complex to induce apoptosis. Oncogene19: 6342–6350 ArticleCASPubMed Google Scholar
Eskes R, Antonsson B, Osen-Sand A, Montessuit S, Richter C, Sadoul R, Mazzei G, Nicholas A and Martinou JC (1998) Bax-induced cytochrome c release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions. J. Cell Biol.143: 217–224 ArticleCASPubMedPubMed Central Google Scholar
Russell JW, Golovoy D, Vincent AM, Mahendru P, Olzmann JA, Mentzer A and Feldman EL (2002) High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J.16: 1738–1748 ArticleCASPubMed Google Scholar
Zamzami N, Susin SA, Marchetti P, Hirsch T, Gomez-Monterrey I, Castedo M and Kroemer G (1996) Mitochondrial control of nuclear apoptosis. J. Exp. Med.183: 1533–1544 ArticleCASPubMed Google Scholar
Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H and Tsujimoto Y (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. USA95: 14681–14686 ArticleCASPubMedPubMed Central Google Scholar
Russell JW, Sullivan KA, Windebank AJ, Herrmann DN and Feldman EL (1999) Neurons undergo apoptosis in animal and cell culture models of diabetes. Neurobiol. Dis.6: 347–363 ArticleCASPubMed Google Scholar
Russell JW and Feldman EL (1999) Insulin-like growth factor-I prevents apoptosis in sympathetic neurons exposed to high glucose. Horm. Metab. Res.31: 90–96 ArticleCASPubMed Google Scholar
Mack A, Furmann C and Hacker G (2000) Detection of caspase-activation in intact lymphoid cells using standard caspase substrates and inhibitors. J. Immunol. Methods241: 19–31 ArticleCASPubMed Google Scholar
Scaffidi C, Medema JP, Krammer PH and Peter ME (1997) FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. J. Biol. Chem.272: 26953–26958 ArticleCASPubMed Google Scholar
Yamanaka Y, Hamazaki Y, Sato Y, Ito K, Watanabe K, Heike T, Nakahata T and Nakamura Y (2002) Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays. Int. J. Oncol.21: 803–807 CASPubMed Google Scholar
Takita J, Yang HW, Chen YY, Hanada R, Yamamoto K, Teitz T, Kidd V and Hayashi Y (2001) Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma. Oncogene20: 4424–4432 ArticleCASPubMed Google Scholar
Goping IS, Gross A, Lavoie JN, Nguyen M, Jemmerson R, Roth K, Korsmeyer SJ and Shore GC (1998) Regulated targeting of BAX to mitochondria. J. Cell Biol.143: 207–215 ArticleCASPubMedPubMed Central Google Scholar
Rebbaa A, Chou PM, Emran M and Mirkin BL (2001) Doxorubicin-induced apoptosis in caspase-8-deficient neuroblastoma cells is mediated through direct action on mitochondria. Cancer Chemother. Pharmacol.48: 423–428 ArticleCASPubMed Google Scholar
Schmeichel AM, Schmelzer JD and Low PA (2003) Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes52: 165–171 ArticleCASPubMed Google Scholar
Srinivasan S, Stevens MJ and Wiley JW (2000) Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction. Diabetes49: 1932–1938 ArticleCASPubMed Google Scholar
Vincent AM, Brownlee M and Russell JW (2002) Oxidative stress and programmed cell death in diabetic neuropathy. Ann. NY Acad. Sci.959: 368–383 ArticleCASPubMed Google Scholar
Poppe M, Reimertz C, Dussmann H, Krohn AJ, Luetjens CM, Bockelmann D, Nieminen AL, Kogel D and Prehn JH (2001) Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis. J. Neurosci.21: 4551–4563 ArticleCASPubMedPubMed Central Google Scholar
Liu X and Zhu XZ (1999) Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor. Brain Res. Mol. Brain Res.71: 210–216 ArticleCASPubMed Google Scholar
Kroemer G, Dallaporta B and Resche-Rigon M (1998) The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol.60: 619–642 ArticleCASPubMed Google Scholar
Boss O, Muzzin P and Giacobino JP (1998) The uncoupling proteins, a review. Eur. J. Endocrinol.139: 1–9 ArticleCASPubMed Google Scholar
Guerra C, Benito M and Fernandez M (1994) IGF-I induces the uncoupling protein gene expression in fetal rat brown adipocyte primary cultures: role of C/EBP transcription factors. Biochem. Biophys. Res. Commun.201: 813–819 ArticleCASPubMed Google Scholar
Horvath TL, Warden CH, Hajos M, Lombardi A, Goglia F and Diano S (1999) Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J. Neurosci.19: 10417–10427 ArticleCASPubMedPubMed Central Google Scholar
Havel PJ, Hahn TM, Sindelar DK, Baskin DG, Dallman MF, Weigle DS and Schwartz MW (2000) Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes49: 244–252 ArticleCASPubMed Google Scholar
Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P and Giacobino JP (1997) Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett.408: 39–42 ArticleCASPubMed Google Scholar
Jezek P, Costa AD and Vercesi AE (1996) Evidence for anion-translocating plant uncoupling mitochondrial protein in potato mitochondria. J. Biol. Chem.271: 32743–32748 ArticleCASPubMed Google Scholar
Adams JM and Cory S (1998) The Bcl-2 protein family: arbiters of cell survival. Science281: 1322–1326 ArticleCASPubMed Google Scholar
van Noesel MM, Pieters R, Voute PA and Versteeg R (2003) The N-myc paradox: N-myc overexpression in neuroblastomas is associated with sensitivity as well as resistance to apoptosis. Cancer Lett.197: 165–172 ArticleCASPubMed Google Scholar
Teitz T, Wei T, Liu D, Valentine V, Valentine M, Grenet J, Lahti JM and Kidd VJ (2002) Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. Oncogene21: 1848–1858 ArticleCASPubMed Google Scholar
Allen DA, Harwood S, Varagunam M, Raftery MJ and Yaqoob MM (2003) High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases. FASEB J.17: 908–910 ArticleCASPubMed Google Scholar
Fujita E, Egashira J, Urase K, Kuida K and Momoi T (2001) Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo. Cell Death Differ.8: 335–344 ArticleCASPubMed Google Scholar
McGinnis KM, Gnegy ME and Wang KK (1999) Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis. J. Neurochem.72: 1899–1906 ArticleCASPubMed Google Scholar
Saikumar P, Dong Y, Patel Y, Hall K, Hopfer U, Weinberg J and Venkatachalam MA (1999) Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. Oncogene17: 3401–3415 ArticleCAS Google Scholar
von Harsdorf R, Li P and Dietz R (1999) Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation99: 2934–2941 ArticleCASPubMed Google Scholar
Feldman EL, Stevens MJ and Greene DA (1997) Pathogenesis of diabetic neuropathy. Clin. Neurosci.4: 365–370 CASPubMed Google Scholar
Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D and Reed JC (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc. Natl. Acad. Sci. USA95: 4997–5002 ArticleCASPubMedPubMed Central Google Scholar
Saeki M, Maeda S, Wada K and Kamisaki Y (2002) Insulin-like growth factor-1 protects peroxynitrite-induced cell death by preventing cytochrome _c_-induced caspase-3 activation. J. Cell. Biochem.84: 708–716 ArticlePubMedCAS Google Scholar
Gustafsson H, Adamson L, Hedander J, Walum E and Forsby A (2001) Insulin-like growth factor type 1 upregulates uncoupling protein 3. Biochem. Biophys. Res. Commun.287: 1105–1111 ArticleCASPubMed Google Scholar
Russell JW, Windebank AJ, Schenone A and Feldman EL (1998) Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal. J. Neurobiol.36: 455–467 ArticleCASPubMed Google Scholar
Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ and Morrison RS (2000) p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J. Cell Biol.150: 335–347 ArticleCASPubMedPubMed Central Google Scholar
Matsuzaki H, Tamatani M, Mitsuda N, Namikawa K, Kiyama H, Miyake S and Tohyama M (1999) Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. J. Neurochem.73: 2037–2046 CASPubMed Google Scholar
Kang BP, Urbonas A, Baddoo A, Baskin S, Malhotra A and Meggs LG (2003) IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose. Am. J. Physiol. Renal Physiol.285: F1013–F1024 ArticleCASPubMed Google Scholar
Chinnaiyan AM, O’Rourke K, Lane BR and Dixit VM (1997) Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science275: 1122–1126 ArticleCASPubMed Google Scholar
Duan CM, Hawes SB, Prevette T and Clemmons DR (1996) Insulin-like growth factor-I (IGF-I) regulates IGF-binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells. J. Biol. Chem.271: 4280–4288 ArticleCASPubMed Google Scholar
Leventhal PS and Feldman EL (1996) Tyrosine phosphorylation and enhanced expression of paxillin during neuronal differentiation in vitro. J. Biol. Chem.271: 5957–5960 ArticleCASPubMed Google Scholar
Delaney CL, Russell JW, Cheng H-L and Feldman EL (2001) Insulin-like growth factor-I and over-expression of Bcl-xL prevent glucose-mediated apoptosis in Schwann cells. J. Neuropathol. Exp. Neurol.60: 147–160 ArticleCASPubMed Google Scholar