RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis (original) (raw)

• Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806–811.
  Article CAS Google Scholar
• Kennerdell JR, Carthew RW . Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell. 1998;905:1017–1026.
  Article Google Scholar
• Brummelkamp TR, Bernards R, Agami R . A system for stable expression of short interfering RNAs in mammalian cells. Science. 2002;296:550–553.
  Article CAS Google Scholar
• Lee NS, Dohjima T, Bauer G, et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol. 2002;20:500–505.
  Article CAS Google Scholar
• Miyagishi M, Taira K . Development and application of siRNA expression vector. Nucleic Acids Res. 2002;2 (Suppl):113–114.
  Article CAS Google Scholar
• Paddison PJ, Caudy AA, Bernstein E, et al. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 2002;16:948–958.
  Article CAS Google Scholar
• Kawasaki H, Taira K . Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res. 2003;31:700–707.
  Article CAS Google Scholar
• Brummelkamp TR, Bernards R, Agami R . Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell. 2002;2:243–247.
  Article CAS Google Scholar
• Barton GM, Medzhitov R . Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci USA. 2002;99:14943–14945.
  Article CAS Google Scholar
• Qin XF, An DS, Chen IS, et al. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA. 2003;100:183–188.
  Article CAS Google Scholar
• Rubinson DA, Dillon CP, Kwiatkowski AV, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet. 2003;33:401–406.
  Article CAS Google Scholar
• van de Wetering M, Oving I, Muncan V, et al. Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep. 2003;4:609–615.
  Article CAS Google Scholar
• Czauderna F, Santel A, Hinz M, et al. Inducible shRNA expression for application in a prostate cancer mouse model. Nucleic Acids Res. 2003;31:e127.
  Article Google Scholar
• Chen Y, Stamatoyannopoulos G, Song CZ . Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res. 2003;63:4801–4804.
  CAS PubMed Google Scholar
• Birchmeier C, Birchmeier W, Gherardi E, et al. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 2003;4:915–925.
  Article CAS Google Scholar
• Tempest PR, Reeves BR, Spurr NK, et al. Activation of the met oncogene in the human MNNG-HOS cell line involves a chromosomal rearrangement. Carcinogenesis. 1986;7:2051–2057.
  Article CAS Google Scholar
• Rodrigues GA, Park M . Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase. Mol Cell Biol. 1993;13:6711–6722.
  Article CAS Google Scholar
• Sharashidze LK, Beniashvili DSh, Sherenesheva NI, et al. Induction of gastric cancer in monkeys by _N_-methyl-_N_-nitro-_N_-nitrosoguanidine (MNNG). Neoplasma. 1989;36:129–133.
  CAS PubMed Google Scholar
• Soman NR, Correa P, Ruiz BA, et al. The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. Proc Natl Acad Sci USA. 1991;88:4892–4896.
  Article CAS Google Scholar
• Yu J, Miehlke S, Ebert MP, et al. Frequency of TPR-MET rearrangement in patients with gastric carcinoma and in first-degree relatives. Cancer. 2000;88:1801–1806.
  Article CAS Google Scholar
• Deng D, Xin H . Formation of _N_-(nitrosomethyl)urea in stomachs of experimental pigs and human volunteers given fish sauce in vivo. J Agric Food Chem. 2000;48:2495–2498.
  Article CAS Google Scholar
• Sen NP, Seaman SW, Badoo PA, et al. Formation of _N_-nitroso-_N_-methylurea in various samples of smoked/dried fish, fish sauce, seafoods, and ethnic fermented/pickled vegetables following incubation with nitrite under acidic conditions. J Agric Food Chem. 2001;49:2096–2103.
  Article CAS Google Scholar
• Danilkovitch-Miagkova A, Zbar B . Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J Clin Invest. 2002;109:863–867.
  Article CAS Google Scholar
• Lee JH, Han SU, Cho H, et al. A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene. 2000;19:4947–4953.
  Article CAS Google Scholar
• Ma PC, Kijima T, Maulik G . c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res. 2003;63:6272–6281.
  CAS PubMed Google Scholar
• Shinomiya N, Vande Woude GF . Suppression of met expression: a possible cancer treatment. Clin Cancer Res. 2003;9:5085–5090.
  CAS PubMed Google Scholar
• Ma PC, Maulik G, Christensen J, et al. c-Met: structure, functions and potential for therapeutic inhibition. Cancer Metast Rev. 2003;22:309–325.
  Article CAS Google Scholar
• Morotti A, Mila S, Accornero P, et al. K252a inhibits the oncogenic properties of Met, the HGF receptor. Oncogene. 2002;21:4885–4893.
  Article CAS Google Scholar
• Sattler M, Pride YB, Ma P, et al. A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 2003;63:5462–5469.
  CAS PubMed Google Scholar
• Christensen JG, Schreck R, Burrows J, et al. A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res. 2003;63:7345–7355.
  CAS PubMed Google Scholar
• Maritano D, Accornero P, Bonifaci N, et al. Two mutations affecting conserved residues in the Met receptor operate via different mechanisms. Oncogene. 2000;19:1354–1361.
  Article CAS Google Scholar
• Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001;411:494–498.
  Article CAS Google Scholar
• Follenzi A, Ailles LE, Bakovic S, et al. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet. 2000;25:217–222.
  Article CAS Google Scholar
• Weidner KM, Arakaki N, Hartmann G, et al. Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci USA. 1991;88:7001–7005.
  Article CAS Google Scholar
• Goldman JM, Melo JV . Chronic myeloid leukemia — advances in biology and new approaches to treatment. N Engl J Med. 2003;349:1451–1464.
  Article CAS Google Scholar
• Croom KF, Perry CM . Imatinib mesylate: in the treatment of gastrointestinal stromal tumours. Drugs. 2003;63:513–522.
  Article CAS Google Scholar
• Bose S, Deininger M, Gora-Tybor J, et al. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood. 1998;92:3362–3367.
  CAS Google Scholar
• Yang G, Thompson JA, Fang B, et al. Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer. Oncogene. 2003;22:5694–5701.
  Article CAS Google Scholar
• Scherr M, Battmer K, Winkler T, et al. Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood. 2003;101:1566–1569.
  Article CAS Google Scholar
• Hingorani SR, Jacobetz MA, Robertson GP, et al. Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer Res. 2003;63:5198–5202.
  CAS Google Scholar
• Li K, Lin SY, Brunicardi FC, Seu P . Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma. Cancer Res. 2003;63:3593–3597.
  CAS PubMed Google Scholar
• Filleur S, Courtin A, Ait-Si-Ali S, et al. SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. Cancer Res. 2003;63:2319–2322.
  Google Scholar
• Weinstein IB . Cancer, addiction to oncogenes — the Achilles heal of cancer. Science. 2002;297:63–64.
  Article CAS Google Scholar