Suppression of EGFR expression by antisense or small interference RNA inhibits U251 glioma cell growth in vitro and in vivo (original) (raw)
Stewart LA . Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 2002; 359: 1011–1018. ArticleCAS Google Scholar
Mendelsohn J, Baselga J . The EGF receptor family as targets for cancer therapy. Oncogene 2000; 19: 6550–6665. ArticleCAS Google Scholar
Watanabe K, Tachibana O, Sata K, Yonekawa Y, Kleihues P, Ohgaki H . Over-expression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996; 6: 217–223. ArticleCAS Google Scholar
Pu P, Liu X, Liu A, Cui J, Zhang Y . Inhibitory effect of antisense epidermal growth factor receptor RNA on the proliferation of rat C6 glioma cells in vitro and in vivo. J Neurosurg 2000; 92: 132–139. ArticleCAS Google Scholar
Ritter CA, Arteaga CL . The epidermal growth factor receptor-tyrosine kinase: a promising therapeutic target in solid tumors. Semin Oncol 2003; 30 (Suppl 1): 3–11. ArticleCAS Google Scholar
Sanson M, Thillet J, Hoang-Xuan K . Molecular changes in gliomas. Curr Opin Oncol 2004; 16: 607–613. ArticleCAS Google Scholar
Heimberger A, Learn CA, Archer CE, McLendon RE, Chewning TA, Tuck FL et al. Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Can Res 2002; 8: 3496–3502. CAS Google Scholar
Learn CA, Hartzell TL, Wikstrand CJ, Archer GE, Rich JN, Friedman AH et al. Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme. Clin Cancer Res 2004; 10: 3216–3224. ArticleCAS Google Scholar
Carpentier AF . Neuro-oncology: the growing role of chemotherapy in glioma. Lancet Neurol 2005; 4: 4–5. Article Google Scholar
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC . Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806–811. ArticleCAS Google Scholar
Zamore PD . RNA interference: listening to the sound of silence. Nat Struct Biol 2001; 8: 746–751. ArticleCAS Google Scholar
Sijen T, Fleenor J, Simmer F, Thijssen KL, Parrish S, Timmons L et al. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell 2001; 107: 465–476. ArticleCAS Google Scholar
Bernstein E, Caudy AA, Hammond SM, Hannon GJ . Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001; 409: 363–366. ArticleCAS Google Scholar
Hammond SM, Bernstein E, Beach D, Hannon GJ . An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 2000; 404: 293–296. ArticleCAS Google Scholar
Moroni MC, Willingham MC, Beguinot L . EGFR antisense RNA blocks expression of epidermal growth factor receptor and suppresses the transforming phenotype of a human carcinoma cell line. J Biol Chem 1992; 267: 2714–2722. CASPubMed Google Scholar
Kang CS, Pu PY, Li HY, Zhang Z-Y, Qiu M-Z, Huang Q et al. An in vitro study on the suppressive effect of glioma cell growth induced by plasmid-based small interference RNA (siRNA) targeting human Epidermal Growth Factor Receptor. J Neuro-oncol 2005; 74: 267–273. ArticleCAS Google Scholar
Reiter JL, Threadgill DW, Eley GD, Strunk KE, Danielsen AJ, Sinclair CS et al. Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms. Genomics 2001; 71: 1–20. ArticleCAS Google Scholar
Datta SR, Brunet A, Greenberg ME . Cellular survival: a play in three Akts. Genes Dev 1999; 13: 2905–2927. ArticleCAS Google Scholar
Sugawa N, Ekstrand AJ, James CD, Collins VP . Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci USA 1990; 87: 8602–8606. ArticleCAS Google Scholar
Wikstrand CJ, Reist CJ, Archer GE, Zalutsky MR, Bigner DD . The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target. J Neurovirol 1988; 4: 148–158. Article Google Scholar
Nishikawa R, Ji XD, Harmon RC, Lazar CS, Gill GN, Cavenee WK et al. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA 1994; 91: 7727–7731. ArticleCAS Google Scholar
Fan QW, Weiss WA . RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. Oncogene 2005; 2: 829–837. Article Google Scholar
Pu P, Liu X, Liu A, Cui J, Zhang Y . Inhibitory effect of antisense epidermal growth factor receptor RNA on the proliferation of rat C6 glioma cells in vitro and in vivo. J Neurosurg 2000; 92: 132–139. ArticleCAS Google Scholar
Tian XX, Lam PY, Chen J, Pang JC, To SS, Di-Tomaso E et al. Antisense epidermal growth factor receptor RNA transfection in human malignant glioma cells leads to inhibition of proliferation and induction of differentiation. Neuropathol Appl Neurobiol 1998; 24: 389–396. ArticleCAS Google Scholar
Lammering G, Valerie K, Lin PS, Mikkelsen RB, Contessa JN, Feden JP et al. Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor Receptor. Cancer Res 2001; 7: 682–690. CAS Google Scholar
Stea B, Falsey R, Kislin K, Patel J, Glanzberg H, Carey S et al. Time and dose-dependent radiosensitization of the glioblastoma multiforme U251 cells by the EGF receptor tyrosine kinase inhibitor ZD1839 (‘Iressa’). Cancer Lett 2003; 202: 43–51. ArticleCAS Google Scholar
Kubiatowski T, Jang T, Lachyankar MB, Salmonsen R, Nabi RR, Quesenberry PJ et al. Association of increased phosphotidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas. J Neurosurg 2001; 95: 379–380. Google Scholar
Newton HB . Molecular neuro-oncology and development of targeted therapeutic atrategies for brain tumors. Part 2: PI3K/AKT/PTEN, mTOR, SHH/PTCH and angiogenesis. Expert Rev Anticancer Ther 2004; 4: 105–128. ArticleCAS Google Scholar
Holen T, Amarzguioui M, Wiiger MT, Babaie E, Prydz H . Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucl Acids Res 2002; 30: 1757–1766. ArticleCAS Google Scholar
Harborth J, Elbashir SM, Vandenburgh K, Manninga H, Scaringe SA, Weber K et al. Sequence, chemical and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucl Acid Drug Dev 2003; 13: 83–105. ArticleCAS Google Scholar
Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A . Rational siRNA design for RNA interference. Nat Biotechnol 2004; 22: 326–330. ArticleCAS Google Scholar
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A et al. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucl Acids Res 2004; 32: 936–948. ArticleCAS Google Scholar
Sioud M, Sorensen DR . Cationic liposome-mediated delivery of siRNAs in adult mice. Biochem Biophys Res Commun 2003; 312: 1220–1225. ArticleCAS Google Scholar
Muratovska A, Eccles MR . Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett 2004; 558: 63–68. ArticleCAS Google Scholar
Zhang Y, Zhang YF, Bryant J, Charles A, Boado RJ, Pardridge WM . Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin Cancer Res 2004; 10: 3667–3677. ArticleCAS Google Scholar