- Boyer LA, Lee TI, Cole MF, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005; 122:947–956.
Article CAS Google Scholar
- Loh YH, Wu Q, Chew JL, et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006; 38:431–440.
Article CAS Google Scholar
- Lee TI, Jenner RG, Boyer LA, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 2006; 125:301–313.
Article CAS Google Scholar
- Feng GS, Pawson T . Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. Trends Genet 1994; 10:54–58.
Article CAS Google Scholar
- Neel BG, Gu H, Pao L . The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 2003; 28:284–293.
Article CAS Google Scholar
- Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE . Crystal structure of the tyrosine phosphatase SHP-2. Cell 1998; 92:441–450.
Article CAS Google Scholar
- Milarski KL, Saltiel AR . Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J Biol Chem 1994; 269:21239–21243.
CAS PubMed Google Scholar
- Noguchi T, Matozaki T, Horita K, Fujioka Y, Kasuga M . Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. Mol Cell Biol. 1994; 14:6674–6682.
Article CAS Google Scholar
- Tang TL, Freeman RM Jr, O'Reilly AM, Neel BG, Sokol SY . The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 1995; 80:473–483.
Article CAS Google Scholar
- Saxton TM, Henkemeyer M, Gasca S, Shen R, Rossi DJ, Shalaby F, Feng GS, Pawson T . Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J 1997; 16:2352–2364.
Article CAS Google Scholar
- Shi ZQ, Lu W, Feng GS . The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J Bio Chem 1998; 273:4904–4908.
Article CAS Google Scholar
- Chan RJ, Feng GS . PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood 2006. Epub ahead of print.
- Lai LA, Zhao C, Zhang EE, Feng GS .The Shp-2 tyrosine phosphatase. In: Arino J, Alexander D, eds. Protein phosphatases. Vol. 5. Berlin Heidelberg: Springer-Verlag, 2004: 275–299.
Chapter Google Scholar
- Yu DH ., Qu CK, Henegariu O, Lu X, Feng GS . Protein tyrosine phosphatase Shp-2 regulates cell spreading, migration and focal adhesion. J Biol Chem 1998; 273:21125–21131.
Article CAS Google Scholar
- You M, Flick LM, Yu D, Feng GS . Modulation of the Nuclear Factor kappaB Pathway by Shp-2 Tyrosine Phosphatase in Mediating the Induction of Interleukin (IL)-6 by IL-1 or Tumor Necrosis Factor. J Exp Med 2001; 193:101–110.
Article CAS Google Scholar
- You M, Yu DH, Feng GS . Shp-2 tyrosine phosphatase functions as a negative regulator in the interferon-stimulated Jak/STAT pathway. Mol Cell Biol 1999; 19:2416–2424.
Article CAS Google Scholar
- Ali S, Chen Z, Lebrun J, Vogel W, Kharitonenkov A, Kelly PA, Ullrich A . PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation. Embo J 1996; 15:135–142.
Article CAS Google Scholar
- Qu CK, Shi ZQ, Shen R, Tsai FY, Orkin SH, Feng GS . A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol 1997; 17:5499–5507.
Article CAS Google Scholar
- Keller GM, In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 1995; 7:862–869.
Article CAS Google Scholar
- Qu CK, Yu WM, Azzarelli B, Cooper S, Broxmeyer HE, Feng GS . Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol Cell Biol 1998; 18:6075–6082.
Article CAS Google Scholar
- Qu CK, Nguyen S, Chen J, Feng GS . Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood 2001; 97:911–914.
Article CAS Google Scholar
- Chan RJ, Johnson SA, Li Y, Yoder MC, Feng GS . A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood 2003; 102:2074–2080.
Article CAS Google Scholar
- Choi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G . A common precursor for hematopoietic and endothelial cells. Development 1998; 125:725–732.
CAS PubMed Google Scholar
- Kennedy M, Firpo M, Choi K, Wall C, Robertson S, Kabrun N, Keller G . A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature 1997; 386:488–493.
Article CAS Google Scholar
- Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, Hahlen K, Hasle H, Licht JD, Gelb BD . Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003; 34:148–150.
Article CAS Google Scholar
- Qu CK, Feng GS . Shp-2 has a positive regulatory role in ES cell differentiation and proliferation. Oncogene 1998; 17:433–439.
Article CAS Google Scholar
- Raz R, Lee CK, Cannizzaro LA, d'Eustachio P, Levy DE . Essential role of STAT3 for embryonic stem cell pluripotency. Proc Natl Acad Sci USA 1999; 96:2846–2851.
Article CAS Google Scholar
- Niwa H, Burdon T, Chambers I, Smith A . Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998; 12:2048–2060.
Article CAS Google Scholar
- Matsuda T, Nakamura T, Nakao K, Arai T, Katsuki M, Heike T, Yokota T . STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 1999; 18:4261–4269.
Article CAS Google Scholar
- Burdon T, Chambers I, Nichols J, Smith A . Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 1999; 210:30–43.
Article CAS Google Scholar
- Daheron L, Opitz SL, Zaehres H, Lensch WM, Andrews PW, Itskovitz-Eldor J, Daley GQ . 2004. LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells 22:770–778.
Article CAS Google Scholar
- Sumi T, Fujimoto Y, Nakatsuji N, Suemori H . STAT3 is dispensable for maintenance of self-renewal in nonhuman primate embryonic stem cells. Stem Cells 2004; 22:861–872.
Article CAS Google Scholar