Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity (original) (raw)

• Short Report
• Published: 16 November 1999
• Maurizio De Fusco1,
• Muhammad Faiyaz ul Haque2,
• Paolo Aridon1,
• Tiziana Sarno1,
• Muhammad Sohail3,
• Sayed ul Haque4,
• Mahmud Ahmad4,
• Andrea Ballabio1,5,
• Brunella Franco1 &
• …
• Giorgio Casari1

European Journal of Human Genetics volume 7, pages 828–832 (1999)Cite this article

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Abstract

A new syndromic form of X-linked mental retardation associated to obesity, MRXS7, has been localised to Xp11.3–Xq23 in a large Pakistani family. The ten affected males show clinical manifestations of mental retardation, obesity and hypogonadism. The family was genotyped by a set of microsatellite markers spaced at approximately 10 cM intervals on the X chromosome. Linkage to five adjacent microsatellite markers, mapping in the pericentromeric area, was established and a maximum two-point lod score of 3.86 was reached at zero recombination with marker DXS1106. Reduced recombination events around the centromere prevented precise mapping of the gene.

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Authors and Affiliations

1. Telethon Institute of Genetics and Medicine, Milan, Italy
   Wasim Ahmad, Maurizio De Fusco, Paolo Aridon, Tiziana Sarno, Andrea Ballabio, Brunella Franco & Giorgio Casari
2. Department of Neurology, Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL, USA
   Muhammad Faiyaz ul Haque
3. Department of Biochemistry, University of Oxford, UK
   Muhammad Sohail
4. Department of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
   Sayed ul Haque & Mahmud Ahmad
5. Universita' Vita Salute, Milan, Italy
   Andrea Ballabio

Authors

1. Wasim Ahmad
2. Maurizio De Fusco
3. Muhammad Faiyaz ul Haque
4. Paolo Aridon
5. Tiziana Sarno
6. Muhammad Sohail
7. Sayed ul Haque
8. Mahmud Ahmad
9. Andrea Ballabio
10. Brunella Franco
11. Giorgio Casari

Corresponding author

Correspondence toGiorgio Casari.

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Ahmad, W., De Fusco, M., Faiyaz ul Haque, M. et al. Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity.Eur J Hum Genet 7, 828–832 (1999). https://doi.org/10.1038/sj.ejhg.5200376

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• Received: 21 October 1998
• Revised: 21 May 1999
• Accepted: 09 June 1999
• Published: 16 November 1999
• Issue date: 01 October 1999
• DOI: https://doi.org/10.1038/sj.ejhg.5200376

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