No evidence for an involvement of alleles of polymorphisms in the serotonin1Dβ and 7 receptor genes in obesity, underweight or anorexia nervosa (original) (raw)

• Paper
• Published: 10 August 1999
• H Herrmann1,
• T Löhr1,
• K Rosenkranz1,
• A Ziegler2,
• G Lehmkuhl3,
• F Poustka4,
• MH Schmidt5,
• H Mayer6,
• W Siegfried7,
• H Remschmidt1 &
• …
• J Hebebrand1

International Journal of Obesity volume 23, pages 760–763 (1999)Cite this article

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Abstract

The serotonergic (5-hydroxytryptamine, 5-HT) system has been implicated in body weight regulation and in the etiology of anorexia nervosa (AN). Here we describe the screening of the known Phe-124-Cys polymorphism in the 5-HT1Dβ receptor gene and of the known Pro-279-Leu polymorphism in the 5-HT7 receptor gene. For association tests allele frequencies were compared between up to 393 extremely obese children and adolescents, 142 underweight students and 84 patients with AN. None of the association tests revealed nominal _P_-values below 0.3. We conclude that a major role of the investigated polymorphisms in body weight regulation or AN appears unlikely.

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Authors and Affiliations

1. Department of Child and Adolescent Psychiatry, Clinical Research Group, Germany
   A Hinney, H Herrmann, T Löhr, K Rosenkranz, H Remschmidt & J Hebebrand
2. Clinical Research Group, Institute of Medical Biometry and Epidemiology, University of Marburg, Germany
   A Ziegler
3. Departments of Child and Adolescent Psychiatry of the Universities, Clinical Research Group, Cologne, Germany
   G Lehmkuhl
4. Departments of Child and Adolescent Psychiatry of the Universities, Clinical Research Group, Frankfurt, Germany
   F Poustka
5. Departments of Child and Adolescent Psychiatry of the Universities, Clinical Research Group, Heidelberg, Germany
   MH Schmidt
6. Clinical Research Group, Children’s Hospital Hochried, Murnau, Germany
   H Mayer
7. Clinical Research Group, Obesity Treatment Center Insula, Berchtesgaden, Germany
   W Siegfried

Authors

1. A Hinney
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2. H Herrmann
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3. T Löhr
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4. K Rosenkranz
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5. A Ziegler
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6. G Lehmkuhl
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7. F Poustka
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8. MH Schmidt
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9. H Mayer
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10. W Siegfried
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11. H Remschmidt
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12. J Hebebrand
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Hinney, A., Herrmann, H., Löhr, T. et al. No evidence for an involvement of alleles of polymorphisms in the serotonin1Dβ and 7 receptor genes in obesity, underweight or anorexia nervosa.Int J Obes 23, 760–763 (1999). https://doi.org/10.1038/sj.ijo.0800926

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• Received: 12 August 1998
• Revised: 25 January 1999
• Accepted: 01 March 1999
• Published: 10 August 1999
• Issue Date: 01 July 1999
• DOI: https://doi.org/10.1038/sj.ijo.0800926

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