Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm (original) (raw)

• Original Manuscript
• Published: 01 February 1997

Molecular Cytogenetics

Leukemia volume 11, pages 228–232 (1997)Cite this article

• 208 Accesses
• 33 Citations
• Metrics details

Abstract

Deletion of the long arm of human chromosome 6 in acute lymphoblastic leukemia (ALL) has been shown by cytogenetic studies in 4–11% of cases. To characterize further the region of deletion and to precisely establish its frequency, we studied loss of heterozygozity (LOH) in 120 children with ALL using polymorphic markers located from the 6q14-15 chromosomal band to the telomere. LOH was detected in eight patients. A single region of LOH, flanked distally by D6S1594 and proximally by D6S301 was detected. These DNA markers are separated by 6 cM and are approximately located at the 6q21-22 band. Our present results delineate a region that is likely to contain a tumor-suppressor gene involved in a subset of childhood ALLs.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$259.00 per year

only $21.58 per issue

Buy this article

• Purchase on SpringerLink
• Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

• Log in
• Learn about institutional subscriptions
• Read our FAQs
• Contact customer support

Similar content being viewed by others

Author information

Authors and Affiliations

1. INSERM U409, Faculté de Médecine X Bichat, Paris, France
   B Gérard & B Grandchamp
2. Service de Biochimie Génétique and the Service d’Hématologie, Hôpital R Debré, Paris, France
   H Cavé, C Guidal, E Vilmer & B Grandchamp
3. Hôpital Purpan, Toulouse, France
   N Dastugue

Authors

1. B Gérard
   You can also search for this author inPubMed Google Scholar
2. H Cavé
   You can also search for this author inPubMed Google Scholar
3. C Guidal
   You can also search for this author inPubMed Google Scholar
4. N Dastugue
   You can also search for this author inPubMed Google Scholar
5. E Vilmer
   You can also search for this author inPubMed Google Scholar
6. B Grandchamp
   You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Gérard, B., Cavé, H., Guidal, C. et al. Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm.Leukemia 11, 228–232 (1997). https://doi.org/10.1038/sj.leu.2400566

Download citation

• Received: 23 September 1996
• Accepted: 07 November 1996
• Issue Date: 01 February 1997
• DOI: https://doi.org/10.1038/sj.leu.2400566

Keywords

This article is cited by