Sequence conservation of RAG-1 and RAG-2 genes in hematologic malignancies (original) (raw)

Leukemia volume 16, page 1571 (2002)Cite this article

The diversity of the immune repertoire is due to a physiological process of somatic gene rearrangement directed by the V(D)J recombinase. The products of the RAG-1 and RAG-2 genes drive the molecular process of assembly of immunoglobulin and T cell antigen receptor genes. The expression of RAG genes is not restricted to immature lymphocyte populations in the thymus and bone marrow but they are also functional in germinal center B cells.1,2,3,4

It has been postulated that certain chromosomal translocations could be attributed to an illegitimate recombinase activity of this enzymatic complex. Earlier studies have demonstrated that RAG-1 is expressed in a stage-specific manner among acute lymphoblastic leukemia(ALL)/lymphoblastic lymphoma (LBL) cells.5

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Authors and Affiliations

  1. Department of Hematology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain
    MC Mulero, C Estivill, J Sierra & JF Nomdedéu
  2. Department of Genetics, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain
    M Baiget
  3. Department of Hematology, Hospital Morales Meseguer, Murcia, Spain
    J Corral

Authors

  1. MC Mulero
  2. C Estivill
  3. J Corral
  4. J Sierra
  5. M Baiget
  6. JF Nomdedéu

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Mulero, M., Estivill, C., Corral, J. et al. Sequence conservation of RAG-1 and RAG-2 genes in hematologic malignancies.Leukemia 16, 1571 (2002). https://doi.org/10.1038/sj.leu.2402518

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