Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins (original) (raw)
Dexter TM . Regulation of hemopoietic cell growth and development: experimental and clinical studies Leukemia 1989 7: 469–474 Google Scholar
Dorshkind K . Regulation of hemopoiesis by bone marrow stromal cells and their products Annu Rev Immunol 1990 8: 111–137 CASPubMed Google Scholar
Spooncer E, Heyworth CM, Dunn A, Dexter TM . Self-renewal and differentiation of interleukin-3-dependent multipotent stem cells are modulated by stromal cells and serum factors Differentiation 1986 31: 111–118 CASPubMed Google Scholar
Dexter TM, Spooncer E . Growth and differentiation in the hemopoietic system Annu Rev Cell Biol 1987 3: 423–441 CASPubMed Google Scholar
Asosingh K, Gunthert U, Bakkus MH, De Raeve H, Goes E, Van Riet I, Van Camp B, Vanderkerken K . In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells Cancer Res 2000 60: 3096–3104 CASPubMed Google Scholar
Shimakura Y, Kawada H, Ando K, Sato T, Nakamura Y, Tsuji T, Kato S, Hotta T . Murine stromal cell line HESS-5 maintains reconstituting ability of _ex vivo_-generated hematopoietic stem cells from human bone marrow and cytokine-mobilized peripheral blood Stem Cells 2000 18: 183–189 CASPubMed Google Scholar
Koller MR, Oxender M, Jensen TC, Goltry KL, Smith AK . Direct contact between CD34+lin− cells and stroma induces a soluble activity that specifically increases primitive hematopoietic cell production Exp Hematol 1999 27: 734–741 CASPubMed Google Scholar
Bendall LJ, Daniel A, Kortlepel K, Gottlieb DJ . Bone marrow adherent layers inhibit apoptosis of acute myeloid leukemia cells Exp Hematol 1994 22: 1252–1260 CASPubMed Google Scholar
Manabe A, Coustan-Smith E, Behm FG, Raimondi SC, Campana D . Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia Blood 1992 79: 2370–2377 CASPubMed Google Scholar
Panayiotidis P, Jones D, Ganeshaguru K, Foroni L, Hoffbrand AV . Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitroBr J Haematol 1996 92: 97–103 CASPubMed Google Scholar
Garrido SM, Appelbaum FR, Willman CL, Banker DE . Acute myeloid leukemia cells are protected from spontaneous and drug-induced apoptosis by direct contact with a human bone marrow stromal cell line (HS-5) Exp Hematol 2001 29: 448–457 CASPubMed Google Scholar
Kumagai M, Manabe A, Pui CH, Behm FG, Raimondi SC, Hancock ML, Mahmoud H, Crist WM, Campana D . Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome J Clin Invest 1996 97: 755–760 CASPubMedPubMed Central Google Scholar
Gibson LF, Piktel D, Narayanan R, Nunez G, Landreth KS . Stromal cells regulate bcl-2 and bax expression in pro-B cells Exp Hematol 1996 24: 628–637 CASPubMed Google Scholar
Itoh K, Friel J, Laker C, Zeller W, Just U, Bittner S, Nibbs RJ, Harrison PR, Nishikawa SI, Mori KJ, Ostertag W . The role of soluble growth factors in inducing transient growth and clonal extinction of stroma cell dependent erythroblastic leukemia cells Leukemia 1997 11: 1753–1761 CASPubMed Google Scholar
Itoh K, Friel J, Kluge N, Kina T, Kondo-Takaori A, Kawamata S, Uchiyama T, Ostertag W . A novel hematopoietic multilineage clone, Myl-D-7, is stromal cell-dependent and supported by an alternative mechanism(s) independent of stem cell factor/c-kit interaction Blood 1996 87: 3218–3228 CASPubMed Google Scholar
Itoh K, Tezuka H, Sakoda H, Konno M, Nagata K, Uchiyama T, Uchino H, Mori KJ . Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow Exp Hematol 1989 17: 145–153 CASPubMed Google Scholar
Issaad C, Croisille L, Katz A, Vainchenker W, Coulombel L . A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38− progenitor cells in long-term cultures and semisolid assays Blood 1993 81: 2916–2924 CASPubMed Google Scholar
Nishihara M, Wada Y, Ogami K, Ebihara Y, Ishii T, Tsuji K, Ueno H, Asano S, Nakahata T, Maekawa T . A combination of stem cell factor and granulocyte colony-stimulating factor enhances the growth of human progenitor B cells supported by murine stromal cell line MS-5 Eur J Immunol 1998 28: 855–864 CASPubMed Google Scholar
Gan OI, Dorrell C, Pereira DS, Ito CY, Wang JC, Dick JE . Characterization and retroviral transduction of an early human lymphomyeloid precursor assayed in nonswitched long-term culture on murine stroma Exp Hematol 1999 27: 1097–1106 CASPubMed Google Scholar
Auffray I, Dubart A, Izac B, Vainchenker W, Coulombel L . A murine stromal cell line promotes the proliferation of the human factor-dependent leukemic cell line UT-7 Exp Hematol 1994 22: 417–424 CASPubMed Google Scholar
Berardi AC, Meffre E, Pflumio F, Katz A, Vainchenker W, Schiff C, Coulombel L . Individual CD34+CD38lowCD19−CD10− progenitor cells from human cord blood generate B lymphocytes and granulocytes Blood 1997 89: 3554–3564 CASPubMed Google Scholar
Gan OI, Dorrell C, Pereira DS, Ito CY, Wang JC, Dick JE . Characterization and retroviral transduction of an early human lymphomyeloid precursor assayed in nonswitched long-term culture on murine stroma Exp Hematol 1999 27: 1097–1106 CASPubMed Google Scholar
Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R . NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3) Blood 1991 77: 1080–1086 CASPubMed Google Scholar
Andreeff M, Darzynkiewicz Z, Sharpless TK, Clarkson BD, Melamed MR . Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA Blood 1980 55: 282–293 CASPubMed Google Scholar
Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C . A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V J Immunol Meth 1995 184: 39–51 CAS Google Scholar
Horan PK, Slezak SE . Stable cell membrane labelling Nature 1989 340: 167–168 CASPubMed Google Scholar
Traycoff CM, Kosak ST, Grigsby S, Srour EF . Evaluation of ex vivo expansion potential of cord blood and bone marrow hematopoietic progenitor cells using cell tracking and limiting dilution analysis Blood 1995 85: 2059–2068 CASPubMed Google Scholar
Schwartz A, Fernandez-Repollet E . Development of clinical standards for flow cytometry Ann NY Acad Sci 1993 677: 28–39 CASPubMed Google Scholar
Lavabre-Bertrand T, Janossy G, Ivory K, Peter R, Secker-Walker L, Porwit-MacDonald A . Leukemia associated changes identified by quantitative flow cytometry: I. CD10 expression Cytometry 1994 18: 209–217 CASPubMed Google Scholar
Chomozynski P, Sacchi N . Single step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction Anal Biochem 1987 162: 156–159 Google Scholar
Livak KJ . Comparative Ct method. ABI Prism 7700 Sequence Detection System. (User Bulletin No. 2) PE Applied Biosystems 1997 Google Scholar
Kobari L, Dubart A, Le Pasteur F, Vainchenker W, Sainteny F . Hematopoietic-promoting activity of the murine stromal cell line MS-5 is not related to the expression of the major hematopoietic cytokines J Cell Physiol 1995 163: 295–304 CASPubMed Google Scholar
Nishi N, Ishikawa R, Inoue H, Nishikawa M, Yoneya T, Kakeda M, Tsumura H, Ohashi H, Mori KJ . In vitro long-term culture of human primitive hematopoietic cells supported by murine stromal cell line MS-5 Leukemia 1997 11: 468–473 PubMed Google Scholar
Mitjavila MT, Filippi MD, Cohen-Solal K, Le Pasteur F, Vainchenker W, Sainteny F . The Mpl-ligand is involved in the growth-promoting activity of the murine stromal cell line MS-5 on ES cell-derived hematopoiesis Exp Hematol 1998 26: 124–134 CASPubMed Google Scholar
Suzuki J, Fujita J, Taniguchi S, Sugimoto K, Mori KJ . Characterization of murine hemopoietic-supportive (MS1 and MS-5) and non-supportive (MS-K) cell lines Leukemia 1992 6: 452–458 CASPubMed Google Scholar
Nishino T, Hisha H, Nishino N, Adachi M, Ikehara S . Hepatocyte growth factor as a hematopoietic regulator Blood 1995 85: 3093–3100 CASPubMed Google Scholar
Bendall LJ, Kortlepel K, Gottlieb DJ . Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms Blood 1993 82: 3125–3132 CASPubMed Google Scholar
Tanaka Y, Albelda SM, Horgan KJ, van Seventer GA, Shimizu Y, Newman W, Hallam J, Newman PJ, Buck CA, Shaw S . CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion J Exp Med 1992 176: 245–253 CASPubMed Google Scholar
Kinashi T, Springer TA . Steel factor and c-kit regulate cell-matrix adhesion Blood 1994 83: 1033–1038 CASPubMed Google Scholar
Drzeniek Z, Stocker G, Siebertz B, Just U, Schroeder T, Ostertag W, Haubeck HD . Heparan sulfate proteoglycan expression is induced during early erythroid differentiation of multipotent hematopoietic stem cells Blood 1999 93: 2884–2897 CASPubMed Google Scholar
Lopez-Casillas F, Wrana JL, Massague J . Betaglycan presents ligand to the TGF beta signaling receptor Cell 1993 73: 1435–1444 CASPubMed Google Scholar
Lamarre J, Vasudevan J, Gonias SL . Plasmin cleaves betaglycan and releases a 60 kDa transforming growth factor-beta complex from the cell surface Biochem J 1994 302: 199–205 CASPubMedPubMed Central Google Scholar
Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA . A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) J Exp Med 1996 184: 1101–1109 CASPubMed Google Scholar
Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T . Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1 Nature 1996 382: 635–638 CASPubMed Google Scholar
Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA . Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice Proc Natl Acad Sci USA 1998 95: 9448–9453 CASPubMedPubMed Central Google Scholar
Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, Nagler A, Ben Hur H, Many A, Shultz L, Lider O, Alon R, Zipori D, Lapidot T . Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4 Science 1999 283: 845–848 CASPubMed Google Scholar
Deichmann M, Kronenwett R, Haas R . Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34+ hematopoietic progenitor cells Blood 1997 89: 3522–3528 CASPubMed Google Scholar
Mohle R, Bautz F, Rafii S, Moore MA, Brugger W, Kanz L . The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1 Blood 1998 91: 4523–4530 CASPubMed Google Scholar
Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, Marsh M . Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4 J Cell Biol 1997 139: 651–664 CASPubMedPubMed Central Google Scholar
Heberlein C, Friel J, Laker C, von Laer D, Bergholz U, Bogel M, Ashman LK, Klingler K, Ostertag W . Downregulation of c-kit (stem cell factor receptor) in transformed hematopoietic precursor cells by stroma cells Blood 1999 93: 554–563 CASPubMed Google Scholar
Cardoso AA, Keenan TD, Veiga JP, Tse WT, Sallan SE, Guinan EC, Nadler LM . Leukemia milieu differentiates bone marrow mesenchymal stem cells into stromal-like cells that support leukemia cell survival Blood 2001 98: 764a Google Scholar
Coulombel L, Eaves CJ, Eaves AC . Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer Blood 1983 62: 291–297 CASPubMed Google Scholar
Dexter TM, Allen TD, Lajtha LG . Conditions controlling the proliferation of hemopoietic stem cells in vitroJ Cell Physiol 1977 91: 335–344 CASPubMed Google Scholar
Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM . Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitroBlood 1989 74: 1563–1570 CASPubMed Google Scholar
Verfaillie C, Blakolmer K, McGlave P . Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma J Exp Med 1990 172: 509–520 CASPubMed Google Scholar
Bradstock KF, Gottlieb DJ . Interaction of acute leukemia cells with the bone marrow microenvironment: implications for control of minimal residual disease Leuk Lymphoma 1995 18: 1–16 CASPubMed Google Scholar
Takahashi A, Yamamoto K, Okuma M, Sasada M . Bone marrow stromal cells attenuate mitoxantrone cytotoxicity against HL-60 leukemic cells Anticancer Drugs 1992 3: 647–650 CASPubMed Google Scholar
Fisher TC, Milner AE, Gregory CD, Jackman AL, Aherne GW, Hartley JA, Dive C, Hickman JA . Bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways Cancer Res 1993 53: 3321–3326 CASPubMed Google Scholar
Korsmeyer S . Bcl-2 initiates a new category of oncogenes: regulators of cell death Blood 1992 80: 879–886 CASPubMed Google Scholar
Miyashita T, Reed JC . Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line Blood 1993 81: 151–157 CASPubMed Google Scholar
Nunez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ . Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines J Immunol 1990 144: 3602–3610 CASPubMed Google Scholar
Vaux DL, Cory S, Adams JM . Bcl-2 gene promotes haematopoietic cell survival and cooperates with c-myc to immortalize pre-B cells Nature 1988 335: 440–442 CASPubMed Google Scholar
Bradbury DA, Russell NH . Comparative quantitative expression of bcl-2 by normal and leukaemic myeloid cells Br J Haematol 1995 91: 374–379 CASPubMed Google Scholar
Campos L, Rouault JP, Sabido O, Oriol P, Roubi N, Vasselon C, Archimbaud E . High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy Blood 1993 81: 3091–3096 CASPubMed Google Scholar
Karakas T, Maurer U, Weidman E, Miething CC, Hoelzer D, Bergmann L . High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia Ann Oncol 1998 9: 159–165 CASPubMed Google Scholar
Maung ZT, MacLean FR, Reid MM, Pearson AD, Proctor SJ, Hamilton PJ, Hall AG . The relationship between bcl-2 expression and response to chemotherpay in acute leukaemia Br J Haematol 1994 88: 105–109 CASPubMed Google Scholar
Porwit-MacDonald A, Ivory K, Wilkinson S, Wheatley K, Wong L, Janossy G . Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia Leukemia 1995 9: 1191–1198 CASPubMed Google Scholar
Takashita E, Sugimoto K, Adachi Y, Mori KJ . Induction of bcl-2 gene expression by intercellular information from hemopoietic supportive stromal cells to DA-1 cells J Cell Physiol 1994 161: 367–373 CASPubMed Google Scholar
Borner C . Diminished cell proliferation associated with the death-protective activity of Bcl-2 J Biol Chem 1996 271: 12695–12698 CASPubMed Google Scholar
Mazel S, Burtrum D, Petrie HT . Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death J Exp Med 1996 183: 2219–2226 CASPubMed Google Scholar
Linette GP, Li Y, Roth K, Korsmeyer SJ . Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation Proc Natl Acad Sci USA 1996 93: 9545–9552 CASPubMedPubMed Central Google Scholar
Huang DC, O'Reilly LA, Strasser A, Cory S . The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry EMBO J 1997 16: 4628–4638 CASPubMedPubMed Central Google Scholar
Ohkawa H, Harigaya K . Effect of direct cell-to-cell interaction between the KM-102 clonal human marrow stromal cell line and the HL-60 myeloid leukemic cell line on the differentiation and proliferation of the HL-60 line Cancer Res 1987 47: 2879–2882 CASPubMed Google Scholar
Ossenkoppele GJ, Denkers I, Wijermans P, Huijgens PC, Nauta JJ, Beelen RJ, Langenhuijsen MM . Differentiation induction of HL-60 cells in a long-term bone marrow culture of acute myeloid leukemia Leukemia Res 1990 14: 611–616 CAS Google Scholar
Konopleva M, Zhao S, Jiang S, Snell V, Zhang X, Reed JC . Overexpression of antiapoptotic Bcl-XL and Bcl-2 contributes to chemoresistance of quiescent leukemic progenitors and can be selectively reversed by ATRA Blood 1998 92: 600a Google Scholar
Hu ZB, Yang GS, Li M, Miyamoto N, Minden MD, McCulloch EA . Mechanism of cytosine arabinoside toxicity to the blast cells of acute myeloblastic leukemia: involvement of free radicals Leukemia 1995 9: 789–798 CASPubMed Google Scholar
Hu ZB, Minden MD, McCulloch EA . Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells Leukemia 1995 9: 1667–1673 CASPubMed Google Scholar
Hu ZB, Minden MD, McCulloch EA . Phosphorylation of BCL-2 after exposure of human leukemic cells to retinoic acid Blood 1998 92: 1768–1775 CASPubMed Google Scholar
Campos L, Sabido O, Rouault JP, Guyotat D . Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells Blood 1994 84: 595–600 CASPubMed Google Scholar
Keith FJ, Bradbury DA, Zhu YM, Russell NH . Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C Leukemia 1995 9: 131–138 CASPubMed Google Scholar
Konopleva M, Tari A, Lopez-Berestein A, Andreeff M . Inhibition of Bcl-2 with liposomal-delivered antisense oligonucleotides (AS-ODN) induces apoptosis and increases the sensitivity of primary acute myeloid leukemia (AML) cells and cell lines to cytosine arabinoside and doxorubicin Blood 1997 90: 494a Google Scholar
Andreeff M, Leysath C, Konopleva M, Huang Z . Induction of apoptosis in AML by HA14–1: a cell-permeable organic compound identified by protein structure-based computer screening that binds the BH1 to BH3 surface pocket of Bcl-2 Blood 2000 96: 502a Google Scholar
Marcucci G, Bloomfield CD, Balcerzak SP, Kourlas PJ, Stanley HR, Fingert H, Maghraby EA, Lucas D, Chen KK, Byrd JC, Kraut EH, Grever MR, Caligiuri MA . Phase I trial of Genasense™ (G3139, Genta, Inc), a bcl-2 antisense (AS), in refractory (REF) or relapsed (REL) acute leukemia (AL) Blood 2000 96: 119a Google Scholar