NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration (original) (raw)
Wang JCY, Dorrell C, Ito CY, Inamitsu T, Guenechea G, Gan OI et al. Normal and leukemic human stem cells assayed in immune-deficient mice. In: Zon LI (ed) Hematopoiesis A Developmental Approach. New York: Oxford University Press, 2001, pp 99–118. Google Scholar
Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennent B et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 1995; 154: 180–191. CASPubMed Google Scholar
Cashman JD, Lapidot T, Wang JCY, Doedens M, Shultz LD, Lansdorp P et al. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood 1997; 89: 4307–4316. CASPubMed Google Scholar
Cashman JD, Eaves CJ . Human growth factor-enhanced regeneration of transplantable human hematopoietic stem cells in nonobese diabetic/severe combined immunodeficient mice. Blood 1999; 93: 481–487. CASPubMed Google Scholar
Van der Loo JCM, Hanenberg H, Cooper RJ, Luo F-Y, Lazaridis EN, Williams DA . Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells. Blood 1998; 92: 2556–2570. CASPubMed Google Scholar
Bonnet D, Bhatia M, Wang JCY, Kapp U, Dick JE . Cytokine treatment of accessory cells are required to initiate engraftment of purified primitive human hematopoietic cells transplanted at limiting doses into NOD/SCID mice. Bone Marrow Transplant 1999; 23: 203–209. ArticleCASPubMed Google Scholar
Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999; 283: 845–848. ArticleCASPubMed Google Scholar
Lowenberg B, Touw IP . Hematopoietic growth factors and their receptors in acute leukemia. Blood 1993; 81: 281–292. CASPubMed Google Scholar
Jiang X, Lopez A, Holyoake T, Eaves A, Eaves C . Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proc Natl Acad Sci USA 1999; 96: 12804–12809. ArticleCASPubMedPubMed Central Google Scholar
Croizat H . Circulating cytokines in sickle cell patients during steady state. Br J Haematol 1994; 87: 592–597. ArticleCASPubMed Google Scholar
Croizat H, Nagel RL . Circulating cytokines response and the level of erythropoiesis in sickle cell anemia. Am J Hematol 1999; 60: 105–115. ArticleCASPubMed Google Scholar
Croizat H, Ponchio L, Nicolini FE, Nagel RL, Eaves CJ . Primitive haematopoietic progenitors in the blood of patients with sickle cell disease appear to be endogenously mobilized. Br J Haematol 2000; 111: 491–497. ArticleCASPubMed Google Scholar
Lamming CE, Augustin L, Blackstad M, Lund TC, Hebbel RP, Verfaillie CM . Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis. J Clin Invest 2003; 111: 811–819. ArticleCASPubMedPubMed Central Google Scholar
Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ . Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proc Natl Acad Sci USA 1997; 94: 4698–4703. ArticleCASPubMedPubMed Central Google Scholar
Yonemura Y, Ku H, Hirayama F, Souza LM, Ogawa M . Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells. Proc Natl Acad Sci USA 1996; 93: 4040–4044. ArticleCASPubMedPubMed Central Google Scholar
Feuring-Buske M, Gerhard B, Cashman J, Humphries RK, Eaves CJ, Hogge DE . Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia 2003; 17: 760–763. ArticleCASPubMed Google Scholar
Nishikawa S-I, Nishikawa S, Kawamoto H, Yoshida H, Kizumoto M, Kataoka H et al. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity 1998; 8: 761–769. ArticleCASPubMed Google Scholar
Boggs DR . The total marrow mass of the mouse: a simplified method of measurement. Am J Hematol 1984; 16: 277–286. ArticleCASPubMed Google Scholar
Hogge DE, Lansdorp PM, Reid D, Gerhard B, Eaves CJ . Enhanced detection, maintenance and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human Steel factor, interleukin-3 and granulocyte colony-stimulating factor. Blood 1996; 88: 3765–3773. CASPubMed Google Scholar
Nicolini FE, Holyoake TL, Cashman JD, Chu PPY, Lambie K, Eaves CJ . Unique differentiation programs of human fetal liver stem cells revealed both in vitro and in vivo in NOD/SCID mice. Blood 1999; 94: 2686–2695. CASPubMed Google Scholar
Szilvassy SJ, Humphries RK, Lansdorp PM, Eaves AC, Eaves CJ . Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci USA 1990; 87: 8736–8740. ArticleCASPubMedPubMed Central Google Scholar
Nicola NA . Hemopoietic growth factors and their interactions with specific receptors. J Cell Physiol 1987: Suppl 5: 9–14.
Martin FH, Suggs SV, Langley KE, Lu HS, Ting J, Okino KH et al. Primary structure and functional expression of rat and human stem cell factor DNAs. Cell 1990; 63: 203–211. ArticleCASPubMed Google Scholar
Holyoake TL, Nicolini FE, Eaves CJ . Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow. Exp Hematol 1999; 27: 1418–1427. ArticleCASPubMed Google Scholar
Lapidot T, Pflumio F, Doedens M, Murdoch B, Williams DE, Dick JE . Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 1992; 255: 1137–1141. ArticleCASPubMed Google Scholar
Cashman J, Bockhold K, Hogge DE, Eaves AC, Eaves CJ . Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haematopoietic cells in NOD/SCID mice transplanted with human cord blood. Br J Haematol 1997; 97: 1026–1036. Article Google Scholar
Kyoizumi S, Murray LJ, Namikawa R . Preclinical analysis of cytokine therapy in the SCID-hu mouse. Blood 1993; 81: 1479–1488. CASPubMed Google Scholar
Kapp U, Bhatia M, Bonnet D, Murdoch B, Dick JE . Treatment of non-obese diabetic (NOD)/severe-combined immunodeficient mice (SCID) with flt3 ligand and interleukin-7 impairs the B-lineage commitment of repopulating cells after transplantation of human hematopoietic cells. Blood 1998; 92: 2024–2031. CASPubMed Google Scholar
Bock TA, Orlic D, Dunbar CE, Broxmeyer HE, Bodine DM . Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes. J Exp Med 1995; 182: 2037–2043. ArticleCASPubMed Google Scholar
Metcalf D . Control of granulocytes and macrophages: molecular, cellular, and clinical aspects. Science 1991; 254: 529–533. ArticleCASPubMed Google Scholar
To LB, Haylock DN, Simmons PJ, Juttner CA . The biology and clinical uses of blood stem cells. Blood 1997; 89: 2233–2258. CASPubMed Google Scholar
Thomas J, Liu F, Link DC . Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol 2002; 9: 183–189. ArticlePubMed Google Scholar
Matsunaga T, Hirayama F, Yonemura Y, Murray R, Ogawa M . Negative regulation by interleukin-3 (IL-3) of mouse early B-cell progenitors and stem cells in culture: transduction of the negative signals by _β_c and _β_IL-3 proteins of IL-3 receptor and absence of negative regulation by granulocyte–macrophage colony-stimulating factor. Blood 1998; 92: 901–907. CASPubMed Google Scholar
Wong PMC, Chung S, Dunbar CE, Bodine DM, Ruscetti S, Nienhuis AW . Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder. Mol Cell Biol 1989; 9: 798–808. ArticleCASPubMedPubMed Central Google Scholar
Chang JM, Metcalf D, Lang RA, Gonda TJ, Johnson GR . Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression. Blood 1989; 73: 1487–1497. CASPubMed Google Scholar
Chang JM, Metcalf D, Gonda TJ, Johnson GR . Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice. J Clin Invest 1989; 84: 1488–1496. ArticleCASPubMedPubMed Central Google Scholar
Johnson GR, Gonda TJ, Metcalf D, Hariharan IK, Cory S . A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte–macrophage colony stimulating factor. EMBO J 1989; 8: 441–448. ArticleCASPubMedPubMed Central Google Scholar