- Guiter C, Dusanter-Fourt I, Copie-Bergman C, Boulland ML, Le Gouvello S, Gaulard P et al. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood 2004; 104: 543–549.
Article CAS Google Scholar
- Joos S, Otano-Joos MI, Ziegler S, Bruderlein S, du Manoir S, Bentz M et al. Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. Blood 1996; 87: 1571–1578.
CAS PubMed Google Scholar
- Bentz M, Barth TF, Bruderlein S, Bock D, Schwerer MJ, Baudis M et al. Gain of chromosome arm 9p is characteristic of primary mediastinal B-cell lymphoma (MBL): comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell line. Genes Chromosomes Cancer 2001; 30: 393–401.
Article CAS Google Scholar
- Joos S, Kupper M, Ohl S, von Bonin F, Mechtersheimer G, Bentz M et al. Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells. Cancer Res 2000; 60: 549–552.
CAS PubMed Google Scholar
- Joos S, Menz CK, Wrobel G, Siebert R, Gesk S, Ohl S et al. Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2. Blood 2002; 99: 1381–1387.
Article CAS Google Scholar
- Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, De Leval L et al. The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 2003; 102: 3871–3879.
Article CAS Google Scholar
- Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD et al. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 2003; 198: 851–862.
Article CAS Google Scholar
- Marafioti T, Pozzobon M, Hansmann ML, Delsol G, Pileri SA, Mason DY . Expression of intracellular signaling molecules in classical and lymphocyte predominance Hodgkin disease. Blood 2004; 103: 188–193.
Article CAS Google Scholar
- Jaffe SE, Harris LN, Stein H, Wardiman WJ . Mediastinal (thymic) large B-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds). WHO Classification: Tumours of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon (France), 2001, pp 175–176.
Google Scholar
- Marafioti T, Jones M, Facchetti F, Diss TC, Du MQ, Isaacson PG et al. Phenotype and genotype of interfollicular large B cells, a subpopulation of lymphocytes often with dendritic morphology. Blood 2003; 102: 2868–2876.
Article CAS Google Scholar
- Mason DY, Micklem K, Jones M . Double immunofluorescence labelling of routinely processed paraffin sections. J Pathol 2000; 191: 452–461.
Article CAS Google Scholar
- Pozzobon M, Marafioti T, Hansmann ML, Natkunam Y, Mason DY . Intracellular signalling molecules as immunohistochemical markers of normal and neoplastic human leucocytes in routine biopsy samples. Br J Haematol 2004; 124: 519–533.
Article CAS Google Scholar
- Marafioti T, Pozzobon M, Hansmann M-L, Ventura R, Pileri SA, Roberton H et al. The NFATc1 transcription factor is widely expressed in white cells and translocates from the cytoplasm to the nucleus in a subset of human lymphomas. Br J Haem 2004; 128: 333–342.
Article Google Scholar
- Pulford K, Falini B, Cordell J, Rosenwald A, Ott G, Muller-Hermelink HK et al. Biochemical detection of novel anaplastic lymphoma kinase proteins in tissue sections of anaplastic large cell lymphoma. Am J Pathol 1999; 154: 1657–1663.
Article CAS Google Scholar
- Cazals-Hatem D, Lepage E, Brice P, Ferrant A, d'Agay MF, Baumelou E et al. Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA (‘Groupe d'Etude des Lymphomes de l'Adulte’) study. Am J Surg Pathol 1996; 20: 877–888.
Article CAS Google Scholar
- Lazzarino M, Orlandi E, Paulli M, Strater J, Klersy C, Gianelli U et al. Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma: a multicenter study of 106 patients. J Clin Oncol 1997; 15: 1646–1653.
Article CAS Google Scholar
- Barth TF, Dohner H, Werner CA, Stilgenbauer S, Schlotter M, Pawlita M et al. Characteristic pattern of chromosomal gains and losses in primary large B-cell lymphomas of the gastrointestinal tract. Blood 1998; 91: 4321–4330.
CAS PubMed Google Scholar
- Lamarre L, Jacobson JO, Aisenberg AC, Harris NL . Primary large cell lymphoma of the mediastinum. A histologic and immunophenotypic study of 29 cases. Am J Surg Pathol 1989; 13: 730–739.
Article CAS Google Scholar
- Kanavaros P, Gaulard P, Charlotte F, Martin N, Ducos C, Lebezu M et al. Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas. Am J Pathol 1995; 146: 735–741.
CAS PubMed PubMed Central Google Scholar
- Barth TF, Leithauser F, Joos S, Bentz M, Moller P . Mediastinal (thymic) large B-cell lymphoma: where do we stand? Lancet Oncol 2002; 3: 229–234.
Article Google Scholar
- Pileri SA, Gaidano G, Zinzani PL, Falini B, Gaulard P, Zucca E et al. Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins. Am J Pathol 2003; 162: 243–253.
Article CAS Google Scholar
- Tsang P, Cesarman E, Chadburn A, Liu YF, Knowles DM . Molecular characterization of primary mediastinal B cell lymphoma. Am J Pathol 1996; 148: 2017–2025.
CAS PubMed PubMed Central Google Scholar
- Copie-Bergman C, Gaulard P, Maouche-Chretien L, Briere J, Haioun C, Alonso MA et al. The MAL gene is expressed in primary mediastinal large B-cell lymphoma. Blood 1999; 94: 3567–3575.
CAS PubMed Google Scholar
- Copie-Bergman C, Boulland ML, Dehoulle C, Moller P, Farcet JP, Dyer MJ et al. Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma. Blood 2003; 101: 2756–2761.
Article CAS Google Scholar
- Copie-Bergman C, Plonquet A, Alonso MA, Boulland ML, Marquet J, Divine M et al. MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell lymphomas. Mod Pathol 2002; 15: 1172–1180.
Article Google Scholar
- Ruprai AK, Pringle JH, Angel CA, Kind CN, Lauder I . Localization of immunoglobulin light chain mRNA expression in Hodgkin's disease by in situ hybridization. J Pathol 1991; 164: 37–40.
Article CAS Google Scholar
- Lauritzen AF, Pluzek KJ, Kristensen LE, Nielsen HW . Detection of immunoglobulin light chain mRNA in nodular sclerosing Hodgkin's disease by in situ hybridization with biotinylated oligonucleotide probes compared with immunohistochemical staining with poly- and monoclonal antibodies. Histopathology 1992; 21: 353–358.
Article CAS Google Scholar
- Hell K, Pringle JH, Hansmann ML, Lorenzen J, Colloby P, Lauder I et al. Demonstration of light chain mRNA in Hodgkin's disease. J Pathol 1993; 171: 137–143.
Article CAS Google Scholar
- Marafioti T, Hummel M, Foss HD, Laumen H, Korbjuhn P, Anagnostopoulos I et al. Hodgkin and Reed–Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 2000; 95: 1443–1450.
CAS PubMed Google Scholar
- Schwering I, Brauninger A, Klein U, Jungnickel B, Tinguely M, Diehl V et al. Loss of the B-lineage-specific gene expression program in Hodgkin and Reed–Sternberg cells of Hodgkin lymphoma. Blood 2003; 101: 1505–1512.
Article CAS Google Scholar
- Addis BJ, Isaacson PG . Large cell lymphoma of the mediastinum: a B-cell tumour of probable thymic origin. Histopathology 1986; 10: 379–390.
Article CAS Google Scholar
- Isaacson PG, Norton AJ, Addis BJ . The human thymus contains a novel population of B lymphocytes. Lancet 1987; 2: 1488–1491.
Article CAS Google Scholar