Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors (original) (raw)

Leukemia volume 22, pages 1067–1071 (2008)Cite this article

Hematopoiesis is a tightly regulated multistage process. In the past decade, a number of transcription factors have been identified as crucial regulators in cell proliferation, differentiation and apoptosis in hematopoiesis. The proto-oncogene, LMO2 (also named rbtn2 or ttg2), is such a factor. LMO2 was first cloned from an acute T-lymphocyte leukemia (T-ALL) patient with a (11;14;p13;q11) translocation,1 and subsequently showed crucial functions in hematopoiesis, as well as in angiogenesis.2, 3 LMO2 encodes a LIM-only protein comprised of two LIM domains characterized as a cysteine-rich motif consisting of two tandemly repeated zinc fingers and is considered to be a transcriptional regulator through the interactions with its partners, including LDB1 (CLIM2/NLI1), GATA1, TAL1(SCL) and E47, to form a multi-complex in which LMO2 functions as a bridging molecule with the two arms of GATA1 and TAL1/E47 bound to relevant DNA motifs.4

MicroRNAs (miRNAs) are a recently discovered class of small (≈22-nt), non-coding RNAs that regulate gene expression via the RNA interference pathway either to promote degradation of the target mRNA or to repress its translation. There was increasing evidence showing that miRNAs had crucial functions in hematopoiesis, as well as leukemia (reviewed in Ref. 5). However, there were only a few reports about the expression profiles of miRNAs, and studies on miRNA expression regulations in hematopoiesis are limited. Until now, the best studied is miR-223, which has been shown to be regulated by C/EBPα6, PU.1 and GATA1.7

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Acknowledgements

This work was supported by the National Nature Science Foundation of China (No.30771054).

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Author notes

  1. W Yuan and W Sun: These authors contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Molecular Genetics, Medical College, Nankai University, Tianjin, China
    W Yuan, W Sun, S Yang, J Du, C-L Zhai, Z-Q Wang, J Zhang & T-H Zhu

Authors

  1. W Yuan
  2. W Sun
  3. S Yang
  4. J Du
  5. C-L Zhai
  6. Z-Q Wang
  7. J Zhang
  8. T-H Zhu

Corresponding author

Correspondence toT-H Zhu.

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Yuan, W., Sun, W., Yang, S. et al. Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors.Leukemia 22, 1067–1071 (2008). https://doi.org/10.1038/sj.leu.2405001

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