Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue (original) (raw)
- Cytokines in the Brain
- Published: 01 March 1997
- P M Lenzlinger1,
- V Hans1,
- P Stahel2,
- E Csuka1,
- E Ammann1,
- R Stocker3,
- O Trentz3 &
- …
- T Kossmann3
Molecular Psychiatry volume 2, pages 133–136 (1997)Cite this article
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Abstract
A profound inflammatory response is initiated immediately following traumatic brain injury (TBI) and is characterized by the release of several cytokines with pro- and anti-inflammatory functions. In order to elucidate which cytokines are released in the human brain in response to injury as well as in the peripheral compartment, IL-1, IL-6, IL-8, IL-10, TNF-α and TGF-β were monitored in CSF and serum of severely brain-injured patients. Furthermore, we investigated the possible modulation of systemic reactions by IL-6 and the ability of IL-6 and IL-8 to promote the synthesis of nerve growth factor.
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Authors and Affiliations
- Department of Surgery, Division of Research, University Hospital, Zürich, 8091, Switzerland
M C Morganti-Kossman, P M Lenzlinger, V Hans, E Csuka & E Ammann - Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
P Stahel - Division of Trauma Surgery, University Hospital, Zürich, 8091, Switzerland
R Stocker, O Trentz & T Kossmann
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- M C Morganti-Kossman
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Cite this article
Morganti-Kossman, M., Lenzlinger, P., Hans, V. et al. Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue.Mol Psychiatry 2, 133–136 (1997). https://doi.org/10.1038/sj.mp.4000227
- Accepted: 16 October 1996
- Issue Date: 01 March 1997
- DOI: https://doi.org/10.1038/sj.mp.4000227