Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios (original) (raw)

Molecular Psychiatry volume 4, pages 267–270 (1999)Cite this article

Abstract

A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy _et al_1 using a case-control design with patients with schizophrenia (n = 141) and matched controls (n = 158). The gene may be considered as an excellent candidate gene for psychiatric disorders, since it plays a role in modulating neuronal firing patterns by regulating the slow component of afterhyperpolarisation. In addition, the gene contains a highly polymorphic trinucleotide sequence (CAG) within exon 1, which encodes a polyglutamine stretch. The possible contribution of unstable trinucleotide repeats to the development of psychiatric disorders has previously been discussed.2–4 Chandy _et al_1 reported an over-representation of alleles with higher repeat number in schizophrenics as compared to controls (P = 0.0035). In an attempt to replicate these findings, we have performed a family-based study with 193 offspring/parent combinations using a sample of 49 multiplex families (two or more affected siblings with parents) and a second sample of 83 simplex families (one affected offspring with parents). No evidence for the association of longer repeats with schizophrenia was obtained when each sample was tested separately or when both samples were combined and tested for transmission disequilibrium.

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Authors and Affiliations

  1. Institut für Humangenetik und Anthropologie, Universität Freiburg, Freiburg, D-79106, Germany
    O Wittekindt, E Burgert & D J Morris-Rosendahl
  2. Fakultät für Biologie, Universität Freiburg, Schänzelstr 1, Freiburg, D-79104, Germany
    O Wittekindt
  3. Department of Psychiatry, University of Bonn, Bonn, D-53105, Germany
    S G Schwab, M Rietschel, D Lichtermann, W Maier & D B Wildenauer
  4. Department of Medical Statistics, University of Bonn, Bonn, D-53105, Germany
    M Knapp
  5. Mental State Hospital, Haar, D-85529, Germany
    M Albus & M Borrmann
  6. Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel
    B Lerer & R Segman
  7. Graylands Hospital/University of Western Australia, Centre for Clinical Research in Neuropsychiatry, Mt Claremont, 6010, WA, Australia
    J Hallmayer
  8. FORENAP, Centre Hospitalier, Rouffach, F-68250, France
    M-A Crocq

Authors

  1. O Wittekindt
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  2. S G Schwab
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  3. E Burgert
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  4. M Knapp
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  5. M Albus
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  6. B Lerer
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  7. J Hallmayer
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  8. M Rietschel
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  9. R Segman
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  10. M Borrmann
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  11. D Lichtermann
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  12. M-A Crocq
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  13. W Maier
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  14. D J Morris-Rosendahl
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  15. D B Wildenauer
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Corresponding author

Correspondence toD B Wildenauer.

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Wittekindt, O., Schwab, S., Burgert, E. et al. Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios.Mol Psychiatry 4, 267–270 (1999). https://doi.org/10.1038/sj.mp.4000495

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