Variation at the APOE −491 promoter locus is associated with altered brain levels of apolipoprotein E (original) (raw)

• Mahley RW, Innerarity TL, Rall SC Jr, Weisgraber KH . Plasma lipoproteins: apolipoprotein structure and function J Lipid Res 1984; 25: 1277–1294
  CAS PubMed Google Scholar
• Mahley RW . Apolipoprotein E: cholesterol transport protein with expanding role in cell biology Science 1988; 240: 622–630
  Article CAS Google Scholar
• Pitas RE, Boyles JK, Lee SH et al. Astrocytes synthesize apolipoprotein E and metabolise apolipoprotein E-containing lipoproteins Biochim Biophys Acta 1987; 917: 148–161
  Article CAS Google Scholar
• Zannis VI, Just PW, Breslow JL . Human apolipoprotein E isoprotein subclasses are genetically determined Am J Hum Genet 1981; 33: 11–24
  CAS PubMed PubMed Central Google Scholar
• Strittmatter WJ, Weisgraber KH, Huang DY et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease Proc Natl Acad Sci USA 1993; 90: 8098–8102
  Article CAS Google Scholar
• Martins RN, Clarnette R, Fisher C et al. ApoE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome Neuroreport 1995; 6: 1513–1516
  Article CAS Google Scholar
• Corder EH, Saunders AM, Strittmatter WJ et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 1993; 261: 921–923
  Article CAS Google Scholar
• Taddei K, Clarnette R, Gandy SE, Martins RN . Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease Neurosci Lett 1997; 223: 29–33
  Article Google Scholar
• Laws SM, Taddei K, Martins G et al. The −491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease Neuroreport 1999; 10: 879–882
  Article CAS Google Scholar
• Artiga MJ, Bullido MJ, Sastre I et al. Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene FEBS Lett 1998; 421: 105–108
  Article CAS Google Scholar
• Bullido MJ, Artiga MJ, Recuero M et al. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia Nature Genet 1998; 18: 69–71
  Article CAS Google Scholar
• Lambert JC, Berr C, Pasquier F et al. Pronounced impact of Th1/E47cs mutation compared with −491 AT mutation on neuronal APOE gene expression and risk of developing Alzheimer's disease Hum Mol Gen 1998; 7: 1511–1516
  Article CAS Google Scholar
• Lambert JC, Pasquier F, Cottel D et al. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease Hum Mol Gen 1998; 7: 533–540
  Article CAS Google Scholar
• Hixson JE, Vernier DT . Restriction of human apolipoprotein E by gene amplification and cleavage with Hla1 J Lipid Res 1990; 31: 545–548
  CAS Google Scholar
• Wenham PR, Price WH, Blundell G . Apolipoprotein E genotyping by one-stage PCR Lancet 1991; 337: 1158–1159
  Article CAS Google Scholar
• Diedrich JF, Minnigan H, Carp RI et al. Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes J Virol 1991; 65: 4759–4768
  CAS PubMed PubMed Central Google Scholar
• Wang JC, Kwon JM, Shah P et al. Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease Neurology 2000; 55: 1644–1649
  Article CAS Google Scholar
• Yamada T, Kondo A, Takamatsu J, Tateishi J, Goto I . Apolipoprotein E mRNA in the brains of patients with Alzheimer's disease J Neurol Sci 1995; 129: 56–61
  Article CAS Google Scholar
• Yamagata K, Urakami K, Ikeda K et al. High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer's disease Dement Geriatr Cogn Disord 2001; 12: 57–62
  Article CAS Google Scholar
• Zarow C, Victoroff J . Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning Exp Neurol 1998; 149: 79–86
  Article CAS Google Scholar
• Pirttila T, Soininen H, Heinonen O et al. Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls Brain Res 1996; 722: 71–77
  Article CAS Google Scholar
• Bales KR, Verina T, Dodel RC et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition Nat Genet 1997; 17: 263–264
  Article CAS Google Scholar
• Bales KR, Verina T, Cummins DJ et al. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease Proc Natl Acad Sci USA 1999; 96: 15233–15238
  Article CAS Google Scholar
• Holtzman DM, Bales KR, Tenkova T et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease Proc Natl Acad Sci USA 2000; 97: 2892–2897
  Article CAS Google Scholar
• Holtzman DM, Fagan AM, Mackey B et al. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model Ann Neurol 2000; 47: 739–747
  Article CAS Google Scholar
• Lambert JC, Mann D, Goumidi L et al. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease Lancet 2001; 357: 608–609
  Article CAS Google Scholar