Polymorphisms within 5′ end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population (original) (raw)

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• Published: 02 December 2003

Molecular Psychiatry volume 9, pages 11–12 (2004)Cite this article

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SIR—It has been recently reported that the 5′ end of Neuregulin 1 gene (NRG1) is associated with schizophrenia in Icelandic and Scottish populations.1,2 We confirmed this finding in the present case–control study in a Chinese sample, which analyzed 13 microsatellites extending about 360 kb from upstream of NRG1 to the first intron.

The subjects consisted of 540 unrelated schizophrenic in-patients and 279 controls. All case samples were collected from the Shanghai Mental Health Center. Clinical diagnosis was made according to DSM-IIIR criteria by two independent clinicians. A standard informed consent, which was reviewed and approved by the Shanghai Ethical Committee of Human Genetic Resources, was granted by all the participants. Control individuals were from attendees at hematology clinics in Shanghai. From the polymorphisms used by Stefansson et al1 for genotyping, we chose 13 microsatellite markers, which span around an 800 kb region of chromosome 8pter. The genotyping assay was performed on MegaBACE 1000 instruments (Amersham Biosciences).

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References

1. Stefansson H . et al. Am J Hum Genet 2002; 71: 877–892.
2. Stefansson H . et al. Am J Hum Genet 2003; 72: 83–87.
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Authors and Affiliations

1. Institute of Nutrition Science, Chinese Academy of Sciences, Shanghai, China
   J X Tang, W Y Chen, G He, J Zhou & L He
2. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
   J X Tang, W Y Chen, G He, J Zhou & L He
3. Shanghai Institute of Mental Health, Shanghai, China
   N F Gu & G Y Feng

Authors

1. J X Tang
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2. W Y Chen
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3. G He
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4. J Zhou
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5. N F Gu
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6. G Y Feng
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7. L He
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Corresponding author

Correspondence toL He.

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Tang, J., Chen, W., He, G. et al. Polymorphisms within 5′ end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population.Mol Psychiatry 9, 11–12 (2004). https://doi.org/10.1038/sj.mp.4001436

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• Published: 02 December 2003
• Issue Date: 01 January 2004
• DOI: https://doi.org/10.1038/sj.mp.4001436

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