- Middleton FA, Mirnics K, Pierri JN, Lewis DA, Levitt P . Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J Neurosci 2002; 22: 2718–2729.
Article CAS Google Scholar
- Hakak Y . Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci USA 2001; 98: 4746–4751.
Article CAS Google Scholar
- Torrey EF, Webster M, Knable M, Johnston N, Yolken RH . The stanley foundation brain collection and neuropathology consortium. Schizophr Res 2000; 44: 151–155.
Article CAS Google Scholar
- Alban A, David SO, Bjorkesten L, Andersson C, Sloge E, Lewis S et al. A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics 2003; 3: 36–44.
Article CAS Google Scholar
- Griffin JL, Bollard M, Nicholson JK, Bhakoo K . Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)H NMR spectroscopy. NMR Biomed 2002; 15: 375–384.
Article CAS Google Scholar
- Ryan MM, Huffaker SJ, Webster MJ, Wayland M, Freeman T, Bahn S . Application and optimization of microarray technologies for human post-mortem brain studies. Biol Psychiatry 2003; 55: 329–336.
Article Google Scholar
- Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U et al. Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4: 249–264.
Article Google Scholar
- Rosner B . Percentage points for a generalized ESD many-outlier procedure. Technometrics 1983; 25: 165–172.
Article Google Scholar
- Akaike H . Information theory and an extension of the maximum likelihood principle. Second Internatioanl Symposium on Information Theory. Akademiai Kiado, Budapest, 1973 pp 267–281.
Google Scholar
- Ihaka R, Gentleman R . A language for data analysis and graphics. J Comp Graph Stat 1996; 5: 299–314.
Google Scholar
- Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000; 25: 25–29.
CAS PubMed Google Scholar
- Taylor SW, Fahy E, Zhang B, Glenn GM, Warnock DE, Wiley S et al. Characterization of the human heart mitochondrial proteome. Nat Biotechnol 2003; 21: 281–286.
Article CAS Google Scholar
- Goswami S, Sheets NL, Zavadil J et al. Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult. Invest Ophthalmol Vis Sci 2003; 44: 2084–2093.
Article Google Scholar
- Horie S, Ishii H, Itoh S, Suga T . The noninvolvement of MDH as NAD-oxidoreductase shuttle in rat liver peroxisomes. Biochem Int 1984; 8: 353–359.
CAS PubMed Google Scholar
- Fujii J, Ikeda Y . Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Rep 2002; 7: 123–130.
Article CAS Google Scholar
- Koerkamp MG, Rep M, Bussemaker HJ, Hardy GP, Mul A, Piekarska K et al. Dissection of transient oxidative stress response in Saccharomyces cerevisiae by using DNA microarrays. Mol Biol Cell 2002; 13: 2783–2794.
Article CAS Google Scholar
- Brown GK . Pyruvate dehydrogenase E1 alpha deficiency. J Inherit Metab Dis 1992; 15: 625–633.
Article CAS Google Scholar
- Hertz L, Dienel GA . Energy metabolism in the brain. Int Rev Neurobiol 2002; 51: 1–102.
Article CAS Google Scholar
- Michaelis T, Helms G, Frahm J . Metabolic alterations in brain autopsies: proton NMR identification of free glycerol. NMR Biomed 1996; 9: 121–124.
Article CAS Google Scholar
- Sebastian S, Kenkare UW . Stimulation of brain hexokinase gene expression by recombinant brain insulin-like growth factor in C6 glial cells. Exp Cell Res 1999; 246: 243–247.
Article CAS Google Scholar
- Guan J, Williams CE, Skinner SJ, Mallard EC, Gluckman PD . The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins. Endocrinology 1996; 137: 893–898.
Article CAS Google Scholar
- Roth AD, Leisewitz AV, Jung JE, Cassina P, Barbeito L, Inestrosa NC et al. PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. J Neurosci Res 2003; 72: 425–435.
Article CAS Google Scholar
- Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB et al. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 2003; 362: 798–805.
Article CAS Google Scholar
- Nagarajan R, Svaren J, Le N, Araki T, Watson M, Milbrandt J . EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression. Neuron 2001; 30: 355–368.
Article CAS Google Scholar
- Nagarajan R, Le N, Mahoney H, Araki T, Milbrandt J . Deciphering peripheral nerve myelination by using Schwann cell expression profiling. Proc Natl Acad Sci USA 2002; 99: 8998–9003.
Article CAS Google Scholar
- Ramsay RR, Gandour RD, van der Leij FR . Molecular enzymology of carnitine transfer and transport. Biochim Biophys Acta 2001; 1546: 21–43.
Article CAS Google Scholar
- Heininger K . The cerebral glucose-fatty acid cycle: evolutionary roots, regulation, and (patho)physiological importance. Int Rev Neurobiol 2002; 51: 103–158.
Article CAS Google Scholar
- Sipos I, Tretter L, Adam-Vizi V . Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals. J Neurochem 2003; 84: 112–118.
Article CAS Google Scholar
- Carper DA, Sun JK, Iwata T, Zigler Jr JS, Ibaraki N, Lin LR et al. Oxidative stress induces differential gene expression in a human lens epithelial cell line. Invest Ophthalmol Vis Sci 1999; 40: 400–406.
CAS PubMed Google Scholar
- Cabiscol E, Piulats E, Echave P, Herrero E, Ross J . Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae. J Biol Chem 2000; 275: 27393–27398.
CAS PubMed Google Scholar
- Blass JP . Glucose/mitochondria in neurological conditions. Int Rev Neurobiol 2002; 51: 325–376.
Article CAS Google Scholar
- Gardner PR, Nguyen DD, White CW . Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc Natl Acad Sci USA 1994; 91: 12248–12252.
Article CAS Google Scholar
- Saransaari P, Oja SS . Taurine and neural cell damage. Amino Acids 2000; 19: 509–526.
Article CAS Google Scholar
- Dringen R, Hirrlinger J . Glutathione pathways in the brain. Biol Chem 2003; 384: 505–516.
Article CAS Google Scholar
- Berggren M, Gallegos A, Gasdaska JR, Gasdaska PY, Warneke J, Powis G . Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia. Anticancer Res 1996; 16: 3459–3466.
CAS PubMed Google Scholar
- Das KD, White CW . Redox systems of the cell: possible links and implications. Proc Natl Acad Sci USA 2002; 99: 9617–9618.
Article CAS Google Scholar
- Kang SW, Chae HZ, Seo MS, Kim K, Baines IC, Rhee SG . Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem 1998; 273: 6297–6302.
Article CAS Google Scholar
- Maier CM, Chan PH . Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist 2002; 8: 323–334.
Article CAS Google Scholar
- Demchenko IT, Oury TD, Crapo JD, Piantadosi CA . Regulation of the brain's vascular responses to oxygen. Circ Res 2002; 91: 1031–1037.
Article CAS Google Scholar
- Wheeler MD, Katuna M, Smutney OM et al. Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia–reperfusion injury. Hum Gene Ther 2001; 12: 2167–2177.
Article CAS Google Scholar
- Campagne MV, Thibodeaux H, van Bruggen N, Cairns B, Lowe DG . Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. J Neurosci 2000; 20: 5200–5207.
Article Google Scholar
- Emerson MR, Samson FE, Pazdernik TL . Effects of hypoxia preconditioning on expression of metallothionein-1,2 and heme oxygenase-1 before and after kainic acid-induced seizures. Cell Mol Biol (Noisy-le-grand) 2000; 46: 619–626.
CAS Google Scholar
- Webster KA . Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia. J Exp Biol 2003; 206(part 17): 2911–2922.
Article CAS Google Scholar
- Wenger RH . Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 2002; 16: 1151–1162.
Article CAS Google Scholar
- Heidbreder M, Frohlich F, Johren O, Dendorfer A, Qadri F, Dominiak P . Hypoxia rapidly activates HIF-3alpha mRNA expression. FASEB J 2003; 17: 1541–1543.
Article CAS Google Scholar
- Sharp FR, Bergeron M, Bernaudin M . Hypoxia-inducible factor in brain. Adv Exp Med Biol 2001; 502: 273–291.
Article CAS Google Scholar
- Harris AL . Hypoxia—a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38–47.
Article CAS Google Scholar
- Sakanaka M, Wen TC, Matsuda S, Masuda S, Morishita E, Nagao M et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 1998; 95: 4635–4640.
Article CAS Google Scholar
- Aversa A, Basciani S, Visca P, Arizzi M, Gnessi L, Frajese G et al. Platelet-derived growth factor (PDGF) and PDGF receptors in rat corpus cavernosum: changes in expression after transient in vivo hypoxia. J Endocrinol 2001; 170: 395–402.
Article CAS Google Scholar
- Cheng B, Mattson MP . PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways. J Neurosci 1995; 15: 7095–7104.
Article CAS Google Scholar
- Iihara K, Sasahara M, Hashimoto N, Hazama F . Induction of platelet-derived growth factor beta-receptor in focal ischemia of rat brain. J Cereb Blood Flow Metab 1996; 16: 941–949.
Article CAS Google Scholar
- Sakai Y, Furuichi M, Takahashi M, Mishima M, Iwai S, Shirakawa M et al. A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J Biol Chem 2002; 277: 8579–8587.
Article CAS Google Scholar
- Parikh V, Khan MM, Mahadik SP . Differential effects of antipsychotics on expression of antioxidant enzymes and membrane lipid peroxidation in rat brain. J Psychiatr Res 2003; 37: 43–51.
Article Google Scholar
- Peres M, Bourgeois D, Roussel S, Lefur Y, Devoulon P, Remy C et al. Two-dimensional 1H spectroscopic imaging for evaluating the local metabolic response to focal ischemia in the conscious rat. NMR Biomed 1992; 5: 11–19.
Article CAS Google Scholar
- Ryan MC, Collins P, Thakore JH . Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. Am J Psychiatry 2003; 160: 284–289.
Article Google Scholar
- Henderson DC, Ettinger ER . Schizophrenia and diabetes. Int Rev Neurobiol 2002; 51: 481–501.
Article CAS Google Scholar
- Chambers CB, Lee JM, Troncoso JC, Reich S, Muma NA . Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease. Ann Neurol 1999; 46: 325–332.
Article CAS Google Scholar
- Barrier L . Evidence that acidosis alters the high-affinity dopamine uptake in rat striatal slices and synaptosomes by different mechanisms partially related to oxidative damage. Neurochem Int 2003; 42: 27–34.
Article CAS Google Scholar
- Fedorovich SV, Kaler GV, Konev SV . Effect of low pH on glutamate uptake and release in isolated presynaptic endings from rat brain. Neurochem Res 2003; 28: 715–721.
Article CAS Google Scholar
- Rae C . Is pH a biochemical marker of IQ? Proc R Soc Lond Ser B 1996; 263: 1061–1064.
Article CAS Google Scholar
- Hakak Y, Walker JR, Li C et al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci USA 2001; 98: 4746–4751.
Article CAS Google Scholar
- Brockmann K . Succinate in dystrophic white matter; a proton magnetic resonance spectroscopy finding characteristics for complex II deficiency. Ann Neurol 2002; 52: 38–46.
Article CAS Google Scholar
- Jacobson AM, Samson JA, Weinger K, Ryan CM . Diabetes, the brain, and behavior: is there a biological mechanism underlying the association between diabetes and depression? Int Rev Neurobiol 2002; 51: 455–479.
Article Google Scholar
- Mootha VK . PGC-1 alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34: 267–273.
Article CAS Google Scholar
- Ben-Shachar D . Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine. J Neurochem 2002; 83: 1241–1251.
Article CAS Google Scholar
- van Lookeren Campagne M, Thibodeaux H, van Bruggen N, Cairns B, Gerlai R, Palmer JT et al. Evidence for a protective role of metallothionein-1 in focal cerebral ischemia. Proc Natl Acad Sci USA 1999; 96: 12870–12875.
Article CAS Google Scholar
- Shi Y, Pritchard Jr. KA, Holman P, Rafiee P, Griffith OW, Kalyanaraman B et al. Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. Free Radic Biol Med 2000; 29: 695–703.
Article CAS Google Scholar
- Flavin MP, Yang Y, Ho G . Hypoxia forebrain cholinergic neuron injury: role of glucose, excitatory amino acid receptors and nitric oxide. Neurosci Lett 1993; 164: 5–8.
Article CAS Google Scholar