Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder (original) (raw)

• Vaiva G, Thomas P, Ducrocq F, Fontaine M, Boss V, Devos P et al. Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder. Biol Psychiatry 2004; 55: 250–254.
  Article CAS PubMed Google Scholar
• Harvey BH, Oosthuizen F, Brand L, Wegener G, Stein DJ . Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus. Psychopharmacology (Berl) 2004; 175: 494–502.
  Article CAS Google Scholar
• Lippa AS, Klepner CA, Yunger L, Sano MC, Smith WV, Beer B . Relationship between benzodiazepine receptors and experimental anxiety in rats. Pharmacol Biochem Behav 1978; 9: 853–856.
  Article CAS PubMed Google Scholar
• Medina JH, Novas ML, Wolfman CN, Levi de Stein M, De Robertis E . Benzodiazepine receptors in rat cerebral cortex and hippocampus undergo rapid and reversible changes after acute stress. Neuroscience 1983; 9: 331–335.
  Article CAS PubMed Google Scholar
• Drugan RC, Basile AS, Crawley JN, Paul SM, Skolnick P . Inescapable shock reduces. Pharmacol Biochem Behav 1986; 24: 1673–1677.
  Article CAS PubMed Google Scholar
• Adamec R, Strasser K, Blundell J, Burton P, McKay DW . Protein synthesis and the mechanisms of lasting change in anxiety induced by severe stress. Behav Brain Res 2006; 167: 270–286.
  Article CAS PubMed Google Scholar
• Davidson JR . Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. J Clin Psychiatry 2004; 65 (Suppl 5): 29–33.
  CAS PubMed Google Scholar
• Gelpin E, Bonne O, Peri T, Brandes D, Shalev AY . Treatment of recent trauma survivors with benzodiazepines: a prospective study. J Clin Psychiatry 1996; 57: 390–394.
  CAS PubMed Google Scholar
• Viola J, Ditzler T, Batzer W, Harazin J, Adams D, Lettich L et al. Pharmacological management of post-traumatic stress disorder: clinical summary of a five-year retrospective study, 1990--1995. Mil Med 1997; 162: 616–619.
  Article CAS PubMed Google Scholar
• Connor KM, Davidson JR, Weisler RH, Zhang W, Abraham K . Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment. Psychopharmacology (Berl) 2006; 184: 21–25.
  Article CAS Google Scholar
• Taylor FB . Tiagabine for posttraumatic stress disorder: a case series of 7 women. J Clin Psychiatry 2003; 64: 1421–1425.
  Article PubMed Google Scholar
• Bremner JD, Innis RB, Southwick SM, Staib L, Zoghbi S, Charney DS . Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. Am J Psychiatry 2000; 157: 1120–1126.
  Article CAS PubMed Google Scholar
• Fujita M, Southwick SM, Denucci CC, Zoghbi SS, Dillon MS, Baldwin RM et al. Central type benzodiazepine receptors in Gulf War veterans with posttraumatic stress disorder. Biol Psychiatry 2004; 56: 95–100.
  Article CAS PubMed Google Scholar
• Fedi M, Berkovic SF, Marini C, Mulligan R, Tochon-Danguy H, Reutens DC . A GABAA receptor mutation causing generalized epilepsy reduces benzodiazepine receptor binding. Neuroimage 2006; 32: 995–1000.
  Article PubMed Google Scholar
• Katsifis A, Kassiou M . Development of radioligands for in vivo imaging of GABA(A)-benzodiazepine receptors. Mini Rev Med Chem 2004; 4: 909–921.
  Article CAS PubMed Google Scholar
• Juhasz C, Chugani HT . Imaging the epileptic brain with positron emission tomography. Neuroimaging Clin N Am 2003; 13: 705–716, viii.
  Article PubMed Google Scholar
• Erritzoe D, Talbot P, Frankle WG, Abi-Dargham A . Positron emission tomography and single photon emission CT molecular imaging in schizophrenia. Neuroimaging Clin N Am 2003; 13: 817–832.
  Article PubMed Google Scholar
• Talbot PS, Laruelle M . The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development. Eur Neuropsychopharmacol 2002; 12: 503–511.
  Article CAS PubMed Google Scholar
• First MB, Spitzer RL, Gibbon M, Williams JBW . Structured Clinical Interview for DSM-IV Axis I Disorders. SCID-I/P, 1997.
• Blake D, Weathers F, Nagy L, Kaloupek D, Klauminzer G, Charney D . A Clinican Rating Scale for Assessing Current and Lifetime PTSD: The CAPS-1. Behav Ther 1990; 13: 187–188.
  Google Scholar
• Brix G, Zaers J, Adam LE, Bellemann ME, Ostertag H, Trojan H et al. Performance evaluation of a whole-body PET scanner using the NEMA protocol. National Electrical Manufacturers Association. J Nucl Med 1997; 38: 1614–1623.
  CAS PubMed Google Scholar
• Adam LE, Jears J, Ostertag H, Trojan H, Bellemann ME, Brix G . Performance of the whole-body PET scanner ECAT EXACT HR+ following the IEC standard. IEEE Trans Nucl Sci 1997; 44: 1172–1179.
  Article Google Scholar
• Boellaard R, van Lingen A, van Balen SC, Hoving BG, Lammertsma AA . Characteristics of a new fully programmable blood sampling device for monitoring blood radioactivity during PET. Eur J Nucl Med 2001; 28: 81–89.
  Article CAS PubMed Google Scholar
• Maes F, Collignon A, Vandermeulen D, Marchal G, Suetens P . Multimodality image registration by maximization of mutual information. IEEE Trans Med Imaging 1997; 16: 187–198.
  Article CAS PubMed Google Scholar
• West J, Fitzpatrick JM, Wang MY, Dawant BM, Maurer Jr CR, Kessler RM et al. Comparison and evaluation of retrospective intermodality brain image registration techniques. J Comput Assist Tomogr 1997; 21: 554–566.
  Article CAS PubMed Google Scholar
• Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbol S, Frokjaer VG et al. MR-based automatic delineation of volumes of interest in human brain PET images using probability maps. Neuroimage 2005; 24: 969–979.
  Article PubMed Google Scholar
• Watson C, Andermann F, Gloor P, Jones-Gotman M, Peters T, Evans A et al. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology 1992; 42: 1743–1750.
  Article CAS PubMed Google Scholar
• Duvernoy HM, Bourgouin P . The Human Brain: Surface, Three-Dimensional Sectional Anatomy and MRI, and Blood Supply. Springer Verlag: Vienna, 1999.
  Book Google Scholar
• Greuter HN, van Ophemert PL, Luurtsema G, Franssen EJ, Boellaard R, Lammertsma AA . Validation of a multiwell gamma-counter for measuring high-pressure liquid chromatography metabolite profiles. J Nucl Med Technol 2004; 32: 28–32.
  CAS PubMed Google Scholar
• Koeppe RA, Holthoff VA, Frey KA, Kilbourn MR, Kuhl DE . Compartmental analysis of flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab 1991; 11: 735–744.
  Article CAS PubMed Google Scholar
• Lammertsma AA, Hume SP . Simplified reference tissue model for PET receptor studies. Neuroimage 1996; 4: 153–158.
  Article CAS PubMed Google Scholar
• Klumpers UMH, Veltman DJ, Comans EFI, Kropholler MA, Boellaard R, Hoogendijk WGJ et al. Comparison of various models for analysing [11C] flumazenil studies. J Cereb Blood Flow Metab 2005; 25: S660.
  Article Google Scholar
• Ichise M, Fujita M, Seibyl JP, Verhoeff NP, Baldwin RM, Zoghbi SS et al. Graphical analysis and simplified quantification of striatal and extrastriatal dopamine D2 receptor binding with epidepride SPECT. J Nucl Med 1999; 40: 1902–1912.
  CAS PubMed Google Scholar
• Friston KJ, Frith CD, Liddle PF, Frackowiak RS . Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 1991; 11: 690–699.
  Article CAS PubMed Google Scholar
• Genovese CR, Lazar NA, Nichols T . Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 2002; 15: 870–878.
  Article PubMed Google Scholar
• Caldji C, Francis D, Sharma S, Plotsky PM, Meaney MJ . The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology 2000; 22: 219–229.
  Article CAS PubMed Google Scholar
• Weizman R, Weizman A, Kook KA, Vocci F, Deutsch SI, Paul SM . Repeated swim stress alters brain benzodiazepine receptors measured in vivo. J Pharmacol Exp Ther 1989; 249: 701–707.
  CAS PubMed Google Scholar
• Drugan RC, Morrow AL, Weizman R, Weizman A, Deutsch SI, Crawley JN et al. Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy. Brain Res 1989; 487: 45–51.
  Article CAS PubMed Google Scholar
• Malizia AL, Cunningham VJ, Bell CJ, Liddle PF, Jones T, Nutt DJ . Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Arch Gen Psychiatry 1998; 55: 715–720.
  Article CAS PubMed Google Scholar
• Bremner JD, Vermetten E, Vythilingam M, Afzal N, Schmahl C, Elzinga B et al. Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorder. Biol Psychiatry 2004; 55: 612–620.
  Article PubMed Google Scholar
• Bremner JD, Staib LH, Kaloupek D, Southwick SM, Soufer R, Charney DS . Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biol Psychiatry 1999; 45: 806–816.
  Article CAS PubMed PubMed Central Google Scholar
• Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA et al. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry 1997; 54: 246–254.
  Article CAS PubMed Google Scholar
• Britton JC, Phan KL, Taylor SF, Fig LM, Liberzon I . Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery. Biol Psychiatry 2005; 57: 832–840.
  Article PubMed Google Scholar
• Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B et al. functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 2005; 62: 273–281.
  Article PubMed Google Scholar
• Weber DL, Clark CR, McFarlane AC, Moores KA, Morris P, Egan GF . Abnormal frontal and parietal activity during working memory updating in post-traumatic stress disorder. Psychiatry Res 2005; 140: 27–44.
  Article PubMed Google Scholar
• Lewis DA, Volk DW, Hashimoto T . Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction. Psychopharmacology (Berl) 2004; 174: 143–150.
  Article CAS Google Scholar
• Nazar M, Siemiatkowski M, Czlonkowska A, Sienkiewicz-Jarosz H, Plaznik A . The role of the hippocampus and 5-HT/GABA interaction in the central effects of benzodiazepine receptor ligands. J Neural Transm 1999; 106: 369–381.
  Article CAS PubMed Google Scholar
• Geuze E, Vermetten E, Bremner JD . MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders. Mol Psychiatry 2005; 10: 160–184.
  Article CAS PubMed Google Scholar
• Nemeroff CB, Bremner JD, Foa EB, Mayberg HS, North CS, Stein MB . Posttraumatic stress disorder: a state-of-the-science review. J Psychiatr Res 2006; 40: 1–21.
  Article PubMed Google Scholar
• Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib LH et al. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biol Psychiatry 2003; 53: 879–889.
  Article PubMed Google Scholar
• Sakamoto H, Fukuda R, Okuaki T, Rogers M, Kasai K, Machida T et al. Parahippocampal activation evoked by masked traumatic images in posttraumatic stress disorder: a functional MRI study. Neuroimage 2005; 26: 813–821.
  Article PubMed Google Scholar
• Seabrook GR, Easter A, Dawson GR, Bowery BJ . Modulation of long-term potentiation in CA1 region of mouse hippocampal brain slices by GABAA receptor benzodiazepine site ligands. Neuropharmacology 1997; 36: 823–830.
  Article CAS PubMed Google Scholar
• Bremner JD, Innis RB, White T, Fujita M, Silbersweig D, Goddard AW et al. SPECT. Biol Psychiatry 2000; 47: 96–106.
  Article CAS PubMed Google Scholar
• Debiec J, LeDoux JE . Oradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD. Ann N Y Acad Sci 2006; 1071: 521–524.
  Article CAS PubMed Google Scholar
• Shin LM, Rauch SL, Pitman RK . Mygdala, medial prefrontal cortex, and hippocampal function in PTSD. Ann N Y Acad Sci 2006; 1071: 67–79.
  Article PubMed Google Scholar
• Liberzon I, Martis B . Euroimaging studies of emotional responses in PTSD. Ann N Y Acad Sci 2006; 1071: 87–109.
  Article PubMed Google Scholar
• Geuze E, Westenberg HGM, Jochims A, de Kloet CS, Vermetten E, Schmahl C . Altered pain processing in veterans with posttraumatic stress disorder. Arch Gen Psychiatry 2007; 64: 76–85.
  Article PubMed Google Scholar
• David D, De Faria L, Lapeyra O, Mellman TA . Adjunctive risperidone treatment in combat veterans with chronic PTSD. J Clin Psychopharmacol 2004; 24: 556–559.
  Article PubMed Google Scholar
• Robert S, Hamner MB, Kose S, Ulmer HG, Deitsch SE, Lorberbaum JP . Quetiapine improves sleep disturbances in combat veterans with PTSD: sleep data from a prospective, open-label study. J Clin Psychopharmacol 2005; 25: 387–388.
  Article PubMed Google Scholar
• Ichise M, Meyer JH, Yonekura Y . An introduction to PET and SPECT neuroreceptor quantification models. J Nucl Med 2001; 42: 755–763.
  CAS PubMed Google Scholar
• Watabe H, Matsumoto K, Senda M, Iida H . Performance of list mode data acquisition with ECAT EXACT HR and ECAT EXACT HR+ positron emission scanners. Ann Nucl Med 2006; 20: 189–194.
  Article PubMed Google Scholar