Pharmacological Evidence for a Motivational Role of κ-Opioid Systems in Ethanol Dependence (original) (raw)

• Abbott FV, Franklin KB, Libman RB (1986). A dose-ratio comparison of mu and kappa agonists in formalin and thermal pain. Life Sci 39: 2017–2024.
  Article CAS Google Scholar
• Agmo A, Gomez M (1991). Conditioned place preference produced by infusion of Met-enkephalin into the medial preoptic area. Brain Res 550: 343–346.
  Article CAS Google Scholar
• Amalric M, Cline EJ, Martinez Jr JL, Bloom FE, Koob GF (1987). Rewarding properties of beta-endorphin as measured by conditioned place preference. Psychopharmacology (Berl) 91: 14–19.
  Article CAS Google Scholar
• Anderson WW, Thompson T (1974). Ethanol self-administration in water satiated rats. Pharmacol Biochem Behav 2: 447–454.
  Article CAS Google Scholar
• Anton RF, Pettinati H, Zweben A, Kranzler HR, Johnson B, Bohn MJ et al (2004). A multi-site dose ranging study of nalmefene in the treatment of alcohol dependence. J Clin Psychopharmacol 24: 421–428.
  Article CAS Google Scholar
• Bart G, Schluger JH, Borg L, Ho A, Bidlack JM, Kreek MJ (2005). Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity? Neuropsychopharmacology 30: 2254–2262.
  Article CAS Google Scholar
• Belluzzi JD, Stein L (1977). Enkephaline may mediate euphoria and drive-reduction reward. Nature 266: 556–558.
  Article CAS Google Scholar
• Bozarth MA (1990). Evidence for the rewarding effects of ethanol using the conditioned place preference method. Pharmacol Biochem Behav 35: 485–487.
  Article CAS Google Scholar
• Chen F, Lawrence AJ (2000). Effect of chronic ethanol and withdrawal on the mu-opioid receptor- and 5-hydroxytryptamine(1A) receptor-stimulated binding of [(35)S]guanosine-5′-O-(3-thio)triphosphate in the fawn-hooded rat brain: a quantitative autoradiography study. J Pharmacol Exp Ther 293: 159–165.
  CAS PubMed Google Scholar
• Coonfield DL, Hill KG, Kaczmarek HJ, Ferraro III FM, Kiefer SW (2002). Low doses of naltrexone reduce palatability and consumption of ethanol in outbred rats. Alcohol 26: 43–47.
  Article CAS Google Scholar
• Cowen MS, Lawrence AJ (2001). Alterations in central preproenkephalin mRNA expression after chronic free-choice ethanol consumption by fawn-hooded rats. Alcohol Clin Exp Res 25: 1126–1133.
  Article CAS Google Scholar
• Dai X, Thavundayil J, Gianoulakis C (2005). Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Alcohol Clin Exp Res 29: 1965–1975.
  Article CAS Google Scholar
• Di Chiara G, Imperato A (1988a). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85: 5274–5278.
  Article CAS Google Scholar
• Di Chiara G, Imperato A (1988b). Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther 244: 1067–1080.
  CAS PubMed Google Scholar
• Doyon WM, Howard EC, Shippenberg TS, Gonzales RA (2006). Kappa-opioid receptor modulation of accumbal dopamine concentration during operant ethanol self-administration. Neuropharmacology 51: 487–496.
  Article CAS Google Scholar
• Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Hoffman PL et al (1998). Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res 22: 998–1040.
  Article CAS Google Scholar
• Gianoulakis C, Krishnan B, Thavundayil J (1996). Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism. Arch Gen Psychiatry 53: 250–257.
  Article CAS Google Scholar
• Goeders NE, Lane JD, Smith JE (1984). Self-administration of methionine enkephalin into the nucleus accumbens. Pharmacol Biochem Behav 20: 451–455.
  Article CAS Google Scholar
• Gonzales RA, Weiss F (1998). Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. J Neurosci 18: 10663–10671.
  Article CAS Google Scholar
• Holter SM, Henniger MS, Lipkowski AW, Spanagel R (2000). Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats. Psychopharmacology (Berl) 153: 93–102.
  Article CAS Google Scholar
• Hubbell CL, Abelson ML, Burkhardt CA, Herlands SE, Reid LD (1988). Constant infusions of morphine and intakes of sweetened ethanol solution among rats. Alcohol 5: 409–415.
  Article CAS Google Scholar
• Hyytia P (1993). Involvement of mu-opioid receptors in alcohol drinking by alcohol-preferring AA rats. Pharmacol Biochem Behav 45: 697–701.
  Article CAS Google Scholar
• Jewett DC, Woods JH (1995). Nor-binaltorphimine: an ultra-long acting kappa-opioid antagonist in pigeons. Behav Pharmacol 6: 815–820.
  CAS PubMed Google Scholar
• June HL, Cummings R, Eiler WJ, Foster KL, McKay PF, Seyoum R et al (2004). Central opioid receptors differentially regulate the nalmefene-induced suppression of ethanol- and saccharin-reinforced behaviors in alcohol-preferring (P) rats. Neuropsychopharmacology 29: 285–299.
  Article CAS Google Scholar
• June HL, Grey C, Warren-Reese C, Durr LF, Ricks-Cord A, Johnson A et al (1998). The opioid receptor antagonist nalmefene reduces responding maintained by ethanol presentation: preclinical studies in ethanol-preferring and outbred Wistar rats. Alcohol Clin Exp Res 22: 2174–2185.
  CAS PubMed Google Scholar
• Koob GF, Caine SB, Parsons L, Markou A, Weiss F (1997). Opponent process model and psychostimulant addiction. Pharmacol Biochem Behav 57: 513–521.
  Article CAS Google Scholar
• Koob GF, Le Moal M (1997). Drug abuse: hedonic homeostatic dysregulation. Science 278: 52–58.
  Article CAS Google Scholar
• Koob GF, Le Moal M (2001). Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24: 97–129.
  Article CAS Google Scholar
• Koob GF, Roberts AJ, Kieffer BL, Heyser CJ, Katner SN, Ciccocioppo R et al (2003). Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. Recent Dev Alcohol 16: 263–281.
  PubMed Google Scholar
• Krishnan-Sarin S, Wand GS, Li XW, Portoghese PS, Froehlich JC (1998). Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacol Biochem Behav 59: 627–635.
  Article CAS Google Scholar
• Lindholm S, Ploj K, Franck J, Nylander I (2000). Repeated ethanol administration induces short- and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain. Alcohol 22: 165–171.
  Article CAS Google Scholar
• Mague SD, Pliakas AM, Todtenkopf MS, Tomasiewicz HC, Zhang Y, Stevens Jr WC et al (2003). Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J Pharmacol Exp Ther 305: 323–330.
  Article CAS Google Scholar
• Marglin SH, MacKechnie DK, Mattie ME, Hui YH, Reid LD (1988). Ethanol with small doses of morphine establishes a conditioned place preference. Alcohol 5: 309–313.
  Article CAS Google Scholar
• Margolis EB, Hjelmstad GO, Bonci A, Fields HL (2003). Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J Neurosci 23: 9981–9986.
  Article CAS Google Scholar
• Margolis EB, Lock H, Chefer VI, Shippenberg TS, Hjelmstad GO, Fields HL (2006). Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci USA 103: 2938–2942.
  Article CAS Google Scholar
• Marinelli PW, Bai L, Quirion R, Gianoulakis C (2005). A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration. Alcohol Clin Exp Res 29: 1821–1828.
  Article CAS Google Scholar
• Marinelli PW, Lam M, Bai L, Quirion R, Gianoulakis C (2006). A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administration. Alcohol Clin Exp Res 30: 982–990.
  Article CAS Google Scholar
• Marinelli PW, Quirion R, Gianoulakis C (2003). A microdialysis profile of beta-endorphin and catecholamines in the rat nucleus accumbens following alcohol administration. Psychopharmacology (Berl) 169: 60–67.
  Article CAS Google Scholar
• Marinelli PW, Quirion R, Gianoulakis C (2004). An in vivo profile of beta-endorphin release in the arcuate nucleus and nucleus accumbens following exposure to stress or alcohol. Neuroscience 127: 777–784.
  Article CAS Google Scholar
• Mason BJ, Ritvo EC, Morgan RO, Salvato FR, Goldberg G, Welch B et al (1994). A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence. Alcohol Clin Exp Res 18: 1162–1167.
  Article CAS Google Scholar
• McLaughlin JP, Marton-Popovici M, Chavkin C (2003). Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J Neurosci 23: 5674–5683.
  Article CAS Google Scholar
• Michel ME, Bolger G, Weissman BA (1985). Binding of a new opiate antagonist, nalmefene, to rat brain membranes. Methods Find Exp Clin Pharmacol 7: 175–177.
  CAS PubMed Google Scholar
• Millan MJ (1989). Kappa-opioid receptor-mediated antinociception in the rat. I. Comparative actions of mu- and kappa-opioids against noxious thermal, pressure and electrical stimuli. J Pharmacol Exp Ther 251: 334–341.
  CAS PubMed Google Scholar
• Millan MJ, Czlonkowski A, Lipkowski A, Herz A (1989). Kappa-opioid receptor-mediated antinociception in the rat. II. Supraspinal in addition to spinal sites of action. J Pharmacol Exp Ther 251: 342–350.
  CAS PubMed Google Scholar
• Mucha RF, Herz A (1985). Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology (Berl) 86: 274–280.
  Article CAS Google Scholar
• Newton SS, Thome J, Wallace TL, Shirayama Y, Schlesinger L, Sakai N et al (2002). Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J Neurosci 22: 10883–10890.
  Article CAS Google Scholar
• O'Dell LE, Roberts AJ, Smith RT, Koob GF (2004). Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcohol Clin Exp Res 28: 1676–1682.
  Article CAS Google Scholar
• Paxinos G, Watson C (2005). The Rat Brain in Stereotaxic Coordinates. Elsevier, Academic Press: San Diego.
  Google Scholar
• Picker MJ, Mathewson C, Allen RM (1996). Opioids and rate of positively reinforced behavior: III. Antagonism by the long-lasting kappa antagonist norbinaltorphimine. Behav Pharmacol 7: 495–504.
  CAS PubMed Google Scholar
• Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon Jr WA (2001). Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J Neurosci 21: 7397–7403.
  Article CAS Google Scholar
• Przewlocka B, Turchan J, Lason W, Przewlocki R (1997). Ethanol withdrawal enhances the prodynorphin system activity in the rat nucleus accumbens. Neurosci Lett 238: 13–16.
  Article CAS Google Scholar
• Reid LD (1996). Endogenous opioids and alcohol dependence: opioid alkaloids and the propensity to drink alcoholic beverages. Alcohol 13: 5–11.
  Article CAS Google Scholar
• Roberts AJ, Cole M, Koob GF (1996). Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. Alcohol Clin Exp Res 20: 1289–1298.
  Article CAS Google Scholar
• Roberts AJ, Heyser CJ, Cole M, Griffin P, Koob GF (2000). Excessive ethanol drinking following a history of dependence: animal model of allostasis. Neuropsychopharmacology 22: 581–594.
  Article CAS Google Scholar
• Rogers J, Wiener SG, Bloom FE (1979). Long-term ethanol administration methods for rats: advantages of inhalation over intubation or liquid diets. Behav Neural Biol 27: 466–486.
  Article CAS Google Scholar
• Rosin A, Lindholm S, Franck J, Georgieva J (1999). Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Neurosci Lett 275: 1–4.
  Article CAS Google Scholar
• Rubin DB (1987). Multiple Imputation for Nonresponse in Surveys. J. Wiley & Sons: New York.
  Book Google Scholar
• Rubin DB (1996). Multiple imputation after 18+ years. Journal of the American Statistical Association 91: 473–489.
  Article Google Scholar
• Samson HH (1986). Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10: 436–442.
  Article CAS Google Scholar
• Schafer JL (1999). Multiple imputation: a primer. Stat Methods Med Res 8: 3–15.
  Article CAS Google Scholar
• Schafer JL, Graham JW (2002). Missing data: our view of the state of the art. Psychol Methods 7: 147–177.
  Article Google Scholar
• Schulteis G, Markou A, Cole M, Koob GF (1995). Decreased brain reward produced by ethanol withdrawal. Proc Natl Acad Sci USA 92: 5880–5884.
  Article CAS Google Scholar
• Shirayama Y, Ishida H, Iwata M, Hazama GI, Kawahara R, Duman RS (2004). Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects. J Neurochem 90: 1258–1268.
  Article CAS Google Scholar
• Shoemaker WJ, Vavrousek-Jakuba E, Arons CD, Kwok FC (2002). The acquisition and maintenance of voluntary ethanol drinking in the rat: effects of dopaminergic lesions and naloxone. Behav Brain Res 137: 139–148.
  Article CAS Google Scholar
• Smith SG, Davis WM (1974). Intravenous alcohol self-administration in the rat. Pharmacol Res Commun 6: 379–402.
  Article CAS Google Scholar
• Solomon RL, Corbit JD (1974). An opponent-process theory of motivation. I. Temporal dynamics of affect. Psychol Rev 81: 119–145.
  Article CAS Google Scholar
• Stromberg MF (2004). The effect of baclofen alone and in combination with naltrexone on ethanol consumption in the rat. Pharmacol Biochem Behav 78: 743–750.
  Article CAS Google Scholar
• Stromberg MF, Casale M, Volpicelli L, Volpicelli JR, O'Brien CP (1998). A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat. Alcohol 15: 281–289.
  Article CAS Google Scholar
• Stromberg MF, Mackler SA, Volpicelli JR, O'Brien CP (2001). Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption. Alcohol 23: 109–116.
  Article CAS Google Scholar
• Turchan J, Przewlocka B, Toth G, Lason W, Borsodi A, Przewlocki R (1999). The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience 91: 971–977.
  Article CAS Google Scholar
• Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP (1992). Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49: 876–880.
  Article CAS Google Scholar
• Walker BM, Ettenberg A (2007). Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats. Behav Neurosci 21: 401–410.
  Article Google Scholar
• Walker BM, Koob GF (2007). The GABAB receptor agonist baclofen attenuates operant responding for ethanol in ethanol-dependant rats. Alcohol Clin Exp Res 31: 11–18.
  Article CAS Google Scholar
• Walker EA, Makhay MM, House JD, Young AM (1994). In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats. J Pharmacol Exp Ther 271: 959–968.
  CAS PubMed Google Scholar