A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis (original) (raw)

Oncogene volume 15, pages 2145–2150 (1997) Cite this article

Abstract

The genetic alteration of p53 is associated with neovascularization during progression of glioma to its more malignant form, glioblastoma. Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a 1584-amino-acid product containing five thrombospondin type 1 (TSP-type 1) repeats and is specifically expressed in the brain. A recombinant protein corresponding to the TSP-type 1 repeats of this gene product inhibited in vivo neovascularization induced by bFGF in the rat cornea. The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.

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Authors and Affiliations

  1. Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Japan
    Hiroyuki Nishimori, Takayuki Shiratsuchi, Tsutomu Urano, Yasutoshi Kimura, Yusuke Nakamura & Takashi Tokino
  2. Department of Biochemistry, Kyushu University School of Medicine, Japan
    Shigeo Yoshida, Mayumi Ono & Michihiko Kuwano
  3. Fujii Memorial Research Institute, Otsuka Pharmaceutical Co, Ltd, Japan
    Takayuki Shiratsuchi, Kunihiko Kiyono & Kunihiko Tatsumi

Authors

  1. Hiroyuki Nishimori
  2. Takayuki Shiratsuchi
  3. Tsutomu Urano
  4. Yasutoshi Kimura
  5. Kunihiko Kiyono
  6. Kunihiko Tatsumi
  7. Shigeo Yoshida
  8. Mayumi Ono
  9. Michihiko Kuwano
  10. Yusuke Nakamura
  11. Takashi Tokino

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Nishimori, H., Shiratsuchi, T., Urano, T. et al. A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis.Oncogene 15, 2145–2150 (1997). https://doi.org/10.1038/sj.onc.1201542

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