Homozygous deletions at 3p12 in breast and lung cancer (original) (raw)

Oncogene volume 17, pages 1723–1729 (1998)Cite this article

Abstract

We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.

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Authors and Affiliations

  1. Medical Research Council Centre, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK
    Vasi Sundaresan, Grace Chung, Amanda Heppell-Parton, J Xiong, Ian Roberts, Anthony Cahn, Anthony Bench, Jenny Douglas, Nick Lowe & Pamela Rabbitts
  2. ZENECA Pharmaceuticals, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK
    Catherine Grundy, Louise James & Donald Ogilvie
  3. Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, 75235-8593, Texas, USA
    John Minna & Yoshitaka Sekido
  4. Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research Facility, Bldg. 560, Room 12-25, Frederick, 21701, Maryland, USA
    Michael Lerman, Farida Latif & Hua Li
  5. Department of Oncology, University of Uppsala, Akademiska Sjukhuset, S-751 85 Uppsala, Sweden
    Jonas Bergh

Authors

  1. Vasi Sundaresan
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  2. Grace Chung
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  3. Amanda Heppell-Parton
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  4. J Xiong
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  5. Catherine Grundy
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  6. Ian Roberts
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  7. Louise James
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  8. Anthony Cahn
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  9. Anthony Bench
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  10. Jenny Douglas
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  11. John Minna
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  12. Yoshitaka Sekido
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  13. Michael Lerman
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  14. Farida Latif
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  15. Jonas Bergh
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  16. Hua Li
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  17. Nick Lowe
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  18. Donald Ogilvie
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  19. Pamela Rabbitts
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Sundaresan, V., Chung, G., Heppell-Parton, A. et al. Homozygous deletions at 3p12 in breast and lung cancer.Oncogene 17, 1723–1729 (1998). https://doi.org/10.1038/sj.onc.1202103

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