Homozygous deletions at 3p12 in breast and lung cancer (original) (raw)
- Original Paper
- Published: 01 October 1998
- Grace Chung1,
- Amanda Heppell-Parton1,
- J Xiong1,
- Catherine Grundy2,
- Ian Roberts1,
- Louise James2,
- Anthony Cahn1,
- Anthony Bench1,
- Jenny Douglas1,
- John Minna3,
- Yoshitaka Sekido3,
- Michael Lerman4,
- Farida Latif4,
- Jonas Bergh5,
- Hua Li4,
- Nick Lowe1,
- Donald Ogilvie2 &
- …
- Pamela Rabbitts1
Oncogene volume 17, pages 1723–1729 (1998)Cite this article
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Abstract
We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.
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Authors and Affiliations
- Medical Research Council Centre, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK
Vasi Sundaresan, Grace Chung, Amanda Heppell-Parton, J Xiong, Ian Roberts, Anthony Cahn, Anthony Bench, Jenny Douglas, Nick Lowe & Pamela Rabbitts - ZENECA Pharmaceuticals, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK
Catherine Grundy, Louise James & Donald Ogilvie - Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, 75235-8593, Texas, USA
John Minna & Yoshitaka Sekido - Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research Facility, Bldg. 560, Room 12-25, Frederick, 21701, Maryland, USA
Michael Lerman, Farida Latif & Hua Li - Department of Oncology, University of Uppsala, Akademiska Sjukhuset, S-751 85 Uppsala, Sweden
Jonas Bergh
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- Vasi Sundaresan
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Sundaresan, V., Chung, G., Heppell-Parton, A. et al. Homozygous deletions at 3p12 in breast and lung cancer.Oncogene 17, 1723–1729 (1998). https://doi.org/10.1038/sj.onc.1202103
- Received: 06 March 1998
- Revised: 05 May 1998
- Accepted: 05 May 1998
- Published: 01 October 1998
- Issue Date: 01 October 1998
- DOI: https://doi.org/10.1038/sj.onc.1202103