Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: Evidence for mismatch repair systems in mitochondrial genome (original) (raw)

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• Published: 14 October 1998

Oncogene volume 17, pages 1931–1937 (1998)Cite this article

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Abstract

The role, if any, that mitochondrial (mt) DNA alterations play in the carcinogenic process remains unclear. To determine whether mtDNA instability occurs in cancers, nine microsatellite sequences in the mtDNA were examined in 45 sporadic colorectal carcinomas. Alteration in a polycytidine (C)n tract within a non-coding displacement-loop (D-loop) region was detected in 20 carcinomas (44%), three of which also exhibited frameshift mutations in a polyadenosine (A)8 or polycytidine (C)6 tract within NADH dehydrogenase (ND) genes. Interestingly, all three mutant genes were predicted to encode truncated ND proteins, which lacked a large portion of the C-terminus. These results suggested that certain repair systems, like the mismatch repair systems in the nuclear genome, are required for mtDNA maintenance and that defects in these systems can lead to target mitochondrial gene mutations in colorectal carcinomas.

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Authors and Affiliations

1. Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, 020, Japan
   Wataru Habano, Shin-ichi Nakamura & Tamotsu Sugai

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1. Wataru Habano
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2. Shin-ichi Nakamura
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3. Tamotsu Sugai
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Habano, W., Nakamura, Si. & Sugai, T. Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: Evidence for mismatch repair systems in mitochondrial genome.Oncogene 17, 1931–1937 (1998). https://doi.org/10.1038/sj.onc.1202112

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• Received: 29 December 1997
• Revised: 06 May 1998
• Accepted: 06 May 1998
• Published: 14 October 1998
• Issue Date: 15 October 1998
• DOI: https://doi.org/10.1038/sj.onc.1202112

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