Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes (original) (raw)
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- Published: 17 December 1998
Oncogene volume 17, pages 3145–3156 (1998)Cite this article
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Abstract
Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Jun, Jun-B and Jun-D) proteins to upregulate ARE-mediated expression and coordinated induction of detoxifying enzymes in response to antioxidants and xenobiotics. Nrf-Jun association/heterodimerization and binding to the ARE required unknown cytosolic factor(s). Nrf2 containing one mutated leucine in its leucine zipper region was more efficient in upregulation of ARE-mediated gene expression, as compared to Nrf1 with two mutated leucines.
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Authors and Affiliations
- Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, 77030-3498, Texas, USA
Radjendirane Venugopal & Anil K Jaiswal
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- Radjendirane Venugopal
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Venugopal, R., Jaiswal, A. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.Oncogene 17, 3145–3156 (1998). https://doi.org/10.1038/sj.onc.1202237
- Received: 08 April 1998
- Revised: 22 June 1998
- Accepted: 22 June 1998
- Published: 17 December 1998
- Issue Date: 17 December 1998
- DOI: https://doi.org/10.1038/sj.onc.1202237